ES2106756T3 - Procedimiento para la preparacion de nepinalona. - Google Patents

Procedimiento para la preparacion de nepinalona.

Info

Publication number
ES2106756T3
ES2106756T3 ES91119129T ES91119129T ES2106756T3 ES 2106756 T3 ES2106756 T3 ES 2106756T3 ES 91119129 T ES91119129 T ES 91119129T ES 91119129 T ES91119129 T ES 91119129T ES 2106756 T3 ES2106756 T3 ES 2106756T3
Authority
ES
Spain
Prior art keywords
nepinalone
preparation
procedure
methyl
tetrahidronaftalena
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91119129T
Other languages
English (en)
Inventor
Franco Tenconi
Silvana Furfaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOINDUSTRIA SpA
Bioindustria Farmaceutici SRL
Original Assignee
BIOINDUSTRIA SpA
Bioindustria Farmaceutici SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOINDUSTRIA SpA, Bioindustria Farmaceutici SRL filed Critical BIOINDUSTRIA SpA
Application granted granted Critical
Publication of ES2106756T3 publication Critical patent/ES2106756T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE NEPINALONA. UN PROCESO PARA LA PREPARACION DE HIDROCLORURO DE 1-METIL-1-[2(1-N-PIPERIDINA)ETILO]-1,2,3,4-TETRAHIDRONAFTALENA-2-UNO (TAMBIEN LLAMADO NEPINALONA) QUE CONSISTE EN LA REACCION DE CLORURO DE ACIDO 2-FENILPROPIONICO CON ETILENO, OBTENIENDO 1-METIL-2TETRALONA, QUE REACCIONA POSTERIORMENTE CON 2-CLOROETIL-1-NPIPERIDINA, UTILIZANDO HEPTANO COMO DISOLVENTE; Y POSTERIOR SALIFICACION.
ES91119129T 1991-04-05 1991-11-11 Procedimiento para la preparacion de nepinalona. Expired - Lifetime ES2106756T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910952A IT1245709B (it) 1991-04-05 1991-04-05 Procedimento per la preparazione del nepinalone

Publications (1)

Publication Number Publication Date
ES2106756T3 true ES2106756T3 (es) 1997-11-16

Family

ID=11359472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91119129T Expired - Lifetime ES2106756T3 (es) 1991-04-05 1991-11-11 Procedimiento para la preparacion de nepinalona.

Country Status (8)

Country Link
EP (1) EP0507001B1 (es)
AT (1) ATE158284T1 (es)
DE (1) DE69127687T2 (es)
DK (1) DK0507001T3 (es)
ES (1) ES2106756T3 (es)
GR (1) GR3025664T3 (es)
HK (1) HK1003138A1 (es)
IT (1) IT1245709B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266334A (zh) * 2010-06-04 2011-12-07 北京阜康仁生物制药科技有限公司 含有高纯度奈哌那隆的药用制剂
CN106397158A (zh) * 2016-08-31 2017-02-15 海门华祥医药科技有限公司 一种β‑萘氢酮的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140990A (en) * 1967-05-05 1969-01-22 Warner Lambert Pharmaceutical Novel 1,2,3,4-tetrahydro-naphthalen-2-ones and a process for the preparation thereof

Also Published As

Publication number Publication date
DK0507001T3 (da) 1998-05-11
ITMI910952A0 (it) 1991-04-05
IT1245709B (it) 1994-10-14
EP0507001B1 (en) 1997-09-17
ITMI910952A1 (it) 1992-10-05
HK1003138A1 (en) 1998-10-09
DE69127687T2 (de) 1998-01-15
EP0507001A1 (en) 1992-10-07
DE69127687D1 (de) 1997-10-23
ATE158284T1 (de) 1997-10-15
GR3025664T3 (en) 1998-03-31

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