HUP0000199A3 - Simple process for producing high-purity captopril - Google Patents
Simple process for producing high-purity captoprilInfo
- Publication number
- HUP0000199A3 HUP0000199A3 HU0000199A HUP0000199A HUP0000199A3 HU P0000199 A3 HUP0000199 A3 HU P0000199A3 HU 0000199 A HU0000199 A HU 0000199A HU P0000199 A HUP0000199 A HU P0000199A HU P0000199 A3 HUP0000199 A3 HU P0000199A3
- Authority
- HU
- Hungary
- Prior art keywords
- captopril
- purity
- simple process
- producing high
- producing
- Prior art date
Links
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 title 1
- 229960000830 captopril Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28934096A JP3980684B2 (ja) | 1996-10-11 | 1996-10-11 | 高品質カプトプリルの簡便な製造方法 |
| PCT/JP1997/003655 WO1998016509A1 (fr) | 1996-10-11 | 1997-10-13 | Procede simplifie pour produire du captotril de qualite superieure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000199A2 HUP0000199A2 (hu) | 2000-06-28 |
| HUP0000199A3 true HUP0000199A3 (en) | 2001-12-28 |
Family
ID=17741941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000199A HUP0000199A3 (en) | 1996-10-11 | 1997-10-13 | Simple process for producing high-purity captopril |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6187932B1 (hu) |
| EP (1) | EP0889031B1 (hu) |
| JP (1) | JP3980684B2 (hu) |
| KR (1) | KR19990072045A (hu) |
| AT (1) | ATE231125T1 (hu) |
| CA (1) | CA2249543A1 (hu) |
| DE (1) | DE69718450T2 (hu) |
| ES (1) | ES2191200T3 (hu) |
| HR (1) | HRP970536A2 (hu) |
| HU (1) | HUP0000199A3 (hu) |
| IL (1) | IL124747A (hu) |
| IN (1) | IN183229B (hu) |
| SI (1) | SI9720012A (hu) |
| WO (1) | WO1998016509A1 (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107652215A (zh) * | 2017-09-19 | 2018-02-02 | 重庆西南制药二厂有限责任公司 | 一种卡托普利的制备方法 |
| CN110950792A (zh) * | 2019-12-11 | 2020-04-03 | 华中药业股份有限公司 | 一种卡托普利的改进制备方法 |
| CN116655512A (zh) * | 2023-05-31 | 2023-08-29 | 江苏阿尔法药业股份有限公司 | 一种卡托普利的制备工艺 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5538363A (en) * | 1978-09-13 | 1980-03-17 | Yoshitomi Pharmaceut Ind Ltd | Preparation of optically active n-mercaptoacyl-imino acid |
| US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
| US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
| JP2896818B2 (ja) * | 1991-04-02 | 1999-05-31 | 三菱レイヨン株式会社 | Ｌ−プロリン誘導体の製造法 |
| JPH05221966A (ja) | 1992-02-18 | 1993-08-31 | Mitsubishi Rayon Co Ltd | Ｌ−プロリン誘導体の製造方法 |
| HU211101B (en) * | 1992-03-13 | 1995-10-30 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid |
| US5387697A (en) * | 1994-06-13 | 1995-02-07 | Merck & Co., Inc. | Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline |
| JPH09157251A (ja) | 1995-10-06 | 1997-06-17 | Kanegafuchi Chem Ind Co Ltd | Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法 |
-
1996
- 1996-10-11 JP JP28934096A patent/JP3980684B2/ja not_active Expired - Lifetime
-
1997
- 1997-10-07 IN IN1885CA1997 patent/IN183229B/en unknown
- 1997-10-08 HR HRHEI-8-289340A patent/HRP970536A2/hr not_active Application Discontinuation
- 1997-10-13 AT AT97943179T patent/ATE231125T1/de not_active IP Right Cessation
- 1997-10-13 CA CA002249543A patent/CA2249543A1/en not_active Abandoned
- 1997-10-13 EP EP97943179A patent/EP0889031B1/en not_active Expired - Lifetime
- 1997-10-13 KR KR1019980704339A patent/KR19990072045A/ko not_active Application Discontinuation
- 1997-10-13 US US09/077,747 patent/US6187932B1/en not_active Expired - Fee Related
- 1997-10-13 SI SI9720012A patent/SI9720012A/sl not_active IP Right Cessation
- 1997-10-13 ES ES97943179T patent/ES2191200T3/es not_active Expired - Lifetime
- 1997-10-13 HU HU0000199A patent/HUP0000199A3/hu unknown
- 1997-10-13 IL IL12474797A patent/IL124747A/xx not_active IP Right Cessation
- 1997-10-13 WO PCT/JP1997/003655 patent/WO1998016509A1/ja not_active Application Discontinuation
- 1997-10-13 DE DE69718450T patent/DE69718450T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0889031A4 (en) | 2000-03-22 |
| US6187932B1 (en) | 2001-02-13 |
| DE69718450T2 (de) | 2003-11-20 |
| IL124747A (en) | 2003-05-29 |
| ATE231125T1 (de) | 2003-02-15 |
| DE69718450D1 (de) | 2003-02-20 |
| WO1998016509A1 (fr) | 1998-04-23 |
| EP0889031B1 (en) | 2003-01-15 |
| SI9720012A (sl) | 1998-12-31 |
| IL124747A0 (en) | 1999-01-26 |
| HRP970536A2 (en) | 1998-08-31 |
| EP0889031A1 (en) | 1999-01-07 |
| IN183229B (hu) | 1999-10-09 |
| HUP0000199A2 (hu) | 2000-06-28 |
| CA2249543A1 (en) | 1998-04-23 |
| JPH10114740A (ja) | 1998-05-06 |
| JP3980684B2 (ja) | 2007-09-26 |
| KR19990072045A (ko) | 1999-09-27 |
| ES2191200T3 (es) | 2003-09-01 |
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