KR102913446B1 - 열안정성 cas9 뉴클레아제 - Google Patents

열안정성 cas9 뉴클레아제

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Publication number
KR102913446B1
KR102913446B1 KR1020197020534A KR20197020534A KR102913446B1 KR 102913446 B1 KR102913446 B1 KR 102913446B1 KR 1020197020534 A KR1020197020534 A KR 1020197020534A KR 20197020534 A KR20197020534 A KR 20197020534A KR 102913446 B1 KR102913446 B1 KR 102913446B1
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nucleic acid
sequence
protein
lys
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KR20190104342A (ko
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존 반 더 우스트
리차드 반 크라넨부르크
엘리케 페나 보스마
이오아니스 모우기아코스
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바게닝겐 유니버시테이트
스티칭 부어 드 테크니쉐 웨텐샤펜
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C12N2330/51—Specially adapted vectors
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Plant Pathology (AREA)
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  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020197020534A 2016-12-14 2016-12-14 열안정성 cas9 뉴클레아제 Active KR102913446B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2016/081077 WO2018108272A1 (en) 2016-12-14 2016-12-14 Thermostable cas9 nucleases

Publications (2)

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KR20190104342A KR20190104342A (ko) 2019-09-09
KR102913446B1 true KR102913446B1 (ko) 2026-01-15

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KR1020197020534A Active KR102913446B1 (ko) 2016-12-14 2016-12-14 열안정성 cas9 뉴클레아제
KR1020197020535A Active KR102523544B1 (ko) 2016-12-14 2017-08-16 열안정성 cas9 뉴클레아제
KR1020197020536A Active KR102523543B1 (ko) 2016-12-14 2017-08-16 열안정성 cas9 뉴클레아제
KR1020197020537A Active KR102662270B1 (ko) 2016-12-14 2017-12-14 열안정성 cas9 뉴클레아제

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KR1020197020535A Active KR102523544B1 (ko) 2016-12-14 2017-08-16 열안정성 cas9 뉴클레아제
KR1020197020536A Active KR102523543B1 (ko) 2016-12-14 2017-08-16 열안정성 cas9 뉴클레아제
KR1020197020537A Active KR102662270B1 (ko) 2016-12-14 2017-12-14 열안정성 cas9 뉴클레아제

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US (5) US11242513B2 (https=)
EP (4) EP3555275A1 (https=)
JP (6) JP7182545B2 (https=)
KR (4) KR102913446B1 (https=)
CN (4) CN110312792B (https=)
AU (4) AU2016432443B2 (https=)
BR (3) BR112019012155A2 (https=)
CA (4) CA3046824A1 (https=)
EA (4) EA201991443A1 (https=)
PH (4) PH12019501344A1 (https=)
WO (4) WO2018108272A1 (https=)

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