KR102648965B1 - 간세포 암종 검출 - Google Patents

간세포 암종 검출 Download PDF

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KR102648965B1
KR102648965B1 KR1020197005873A KR20197005873A KR102648965B1 KR 102648965 B1 KR102648965 B1 KR 102648965B1 KR 1020197005873 A KR1020197005873 A KR 1020197005873A KR 20197005873 A KR20197005873 A KR 20197005873A KR 102648965 B1 KR102648965 B1 KR 102648965B1
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methylation
delete delete
dna
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hcc
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KR20190045188A (ko
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윌리엄 알. 테일러
데이비드 에이. 알퀴스트
더글라스 더블유. 마호니
존 비. 키셀
트레이시 씨. 얩
하팀 티. 알라위
마리아 지아코우모파울러스
그라함 피. 리드가드
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메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치
이그잭트 사이언시즈 코포레이션
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/627—Detection means characterised by use of a special device being a mass spectrometer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020197005873A 2016-09-02 2017-09-01 간세포 암종 검출 Active KR102648965B1 (ko)

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US201662383165P 2016-09-02 2016-09-02
US62/383,165 2016-09-02
PCT/US2017/049915 WO2018045322A1 (en) 2016-09-02 2017-09-01 Detecting hepatocellular carcinoma

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KR102648965B1 true KR102648965B1 (ko) 2024-03-18

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EP (2) EP4293128A3 (enExample)
JP (2) JP7293109B2 (enExample)
KR (2) KR102648965B1 (enExample)
CN (2) CN116064795A (enExample)
AU (2) AU2017318700B2 (enExample)
CA (1) CA3034903A1 (enExample)
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CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
KR20250171455A (ko) 2017-01-27 2025-12-08 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
CA3084584A1 (en) 2017-11-30 2019-06-06 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
JP7680365B2 (ja) * 2019-04-03 2025-05-20 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 血漿中の膵管腺癌の検出
WO2020214798A1 (en) * 2019-04-17 2020-10-22 The Brigham And Women's Hospital, Inc. Epigenetic signatures of alzheimer's disease
KR102155044B1 (ko) * 2019-10-08 2020-09-11 주식회사 레피다인 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법
KR102103885B1 (ko) * 2019-10-08 2020-04-24 주식회사 레피다인 생물학적 시료의 간 조직 유래 여부를 판별하는 방법
WO2021075797A2 (ko) * 2019-10-14 2021-04-22 주식회사 젠큐릭스 특정 유전자의 cpg 메틸화 변화를 이용한 간암 진단용 조성물 및 이의 용도
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
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CN117062915A (zh) * 2021-01-12 2023-11-14 里兰斯坦福初级大学理事会 用于癌症诊断和预后的甲基化生物标志的分层分析
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