KR102584280B1 - 키메라 항원 및 t 세포 수용체 및 사용 방법 - Google Patents

키메라 항원 및 t 세포 수용체 및 사용 방법 Download PDF

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KR102584280B1
KR102584280B1 KR1020227026040A KR20227026040A KR102584280B1 KR 102584280 B1 KR102584280 B1 KR 102584280B1 KR 1020227026040 A KR1020227026040 A KR 1020227026040A KR 20227026040 A KR20227026040 A KR 20227026040A KR 102584280 B1 KR102584280 B1 KR 102584280B1
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KR20220110338A (ko
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제드 윌치우스
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카이트 파마 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/244—Interleukins [IL]
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07K2319/00—Fusion polypeptide
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020227026040A 2016-04-01 2017-03-31 키메라 항원 및 t 세포 수용체 및 사용 방법 Active KR102584280B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662317258P 2016-04-01 2016-04-01
US62/317,258 2016-04-01
KR1020187031270A KR102427334B1 (ko) 2016-04-01 2017-03-31 키메라 항원 및 t 세포 수용체 및 사용 방법
PCT/US2017/025351 WO2017173256A1 (en) 2016-04-01 2017-03-31 Chimeric antigen and t cell receptors and methods of use

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KR20220110338A KR20220110338A (ko) 2022-08-05
KR102584280B1 true KR102584280B1 (ko) 2023-10-04

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KR1020187031270A Active KR102427334B1 (ko) 2016-04-01 2017-03-31 키메라 항원 및 t 세포 수용체 및 사용 방법

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US (2) US10603380B2 (https=)
EP (2) EP3984559A1 (https=)
JP (2) JP7034934B2 (https=)
KR (2) KR102584280B1 (https=)
CN (1) CN109328074A (https=)
AR (2) AR108427A1 (https=)
AU (2) AU2017240667C1 (https=)
BR (1) BR112018070073A2 (https=)
CA (1) CA3019149A1 (https=)
CL (2) CL2018002762A1 (https=)
CO (1) CO2018010453A2 (https=)
CR (1) CR20180461A (https=)
CU (1) CU20180121A7 (https=)
DO (1) DOP2018000213A (https=)
EA (1) EA201891965A1 (https=)
EC (1) ECSP18073833A (https=)
ES (1) ES2891578T3 (https=)
IL (2) IL261941B2 (https=)
MX (2) MX391308B (https=)
PE (1) PE20190173A1 (https=)
PH (1) PH12018550163A1 (https=)
PL (1) PL3436079T3 (https=)
PT (1) PT3436079T (https=)
SA (1) SA518400135B1 (https=)
SG (2) SG10201912489QA (https=)
SI (1) SI3436079T1 (https=)
SV (1) SV2018005756A (https=)
TW (3) TW202313671A (https=)
WO (1) WO2017173256A1 (https=)

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GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
MX383150B (es) * 2014-06-02 2025-03-13 Us Health Receptores quiméricos de antígeno que tienen como diana a cd-19.
EP3234120B1 (en) 2014-12-15 2025-09-03 The Regents of the University of California Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
EP4400516A1 (en) 2014-12-15 2024-07-17 The Regents of the University of California Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
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