KR102556825B1 - Smn2 조정을 위한 조성물 및 방법 - Google Patents
Smn2 조정을 위한 조성물 및 방법 Download PDFInfo
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- KR102556825B1 KR102556825B1 KR1020197004350A KR20197004350A KR102556825B1 KR 102556825 B1 KR102556825 B1 KR 102556825B1 KR 1020197004350 A KR1020197004350 A KR 1020197004350A KR 20197004350 A KR20197004350 A KR 20197004350A KR 102556825 B1 KR102556825 B1 KR 102556825B1
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
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Applications Claiming Priority (3)
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| US201662363195P | 2016-07-15 | 2016-07-15 | |
| US62/363,195 | 2016-07-15 | ||
| PCT/US2017/042463 WO2018014041A2 (en) | 2016-07-15 | 2017-07-17 | Compounds and methods for modulation of smn2 |
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| KR20190027907A KR20190027907A (ko) | 2019-03-15 |
| KR102556825B1 true KR102556825B1 (ko) | 2023-07-17 |
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| KR1020197004350A Active KR102556825B1 (ko) | 2016-07-15 | 2017-07-17 | Smn2 조정을 위한 조성물 및 방법 |
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| US9885040B2 (en) * | 2013-04-12 | 2018-02-06 | The Curators Of The University Of Missouri | SMN2 element 1 antisense compositions and methods and uses thereof |
| US10436802B2 (en) | 2014-09-12 | 2019-10-08 | Biogen Ma Inc. | Methods for treating spinal muscular atrophy |
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| EP3436461B1 (en) | 2016-03-28 | 2023-11-01 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
| MY208007A (en) | 2017-09-27 | 2025-04-04 | Incyte Corp | Salts of pyrrolotriazine derivatives useful as tam inhibitors |
| AR117600A1 (es) | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
| BR112022000870A2 (pt) * | 2019-07-19 | 2022-03-22 | Biogen Ma Inc | Métodos de tratamento ou prevenção da atrofia muscular espinhal |
| WO2021030766A1 (en) * | 2019-08-15 | 2021-02-18 | Biogen Ma Inc. | Combination therapy for spinal muscular atrophy |
| JP7737667B2 (ja) * | 2019-09-18 | 2025-09-11 | 国立大学法人東京科学大学 | 核酸複合体 |
| JP7446443B2 (ja) * | 2020-02-28 | 2024-03-08 | アイオーニス ファーマシューティカルズ， インコーポレーテッド | Ｓｍｎ２を調節するための化合物及び方法 |
| EP4114401A1 (en) | 2020-03-06 | 2023-01-11 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| JP2024516183A (ja) * | 2021-04-22 | 2024-04-12 | モレキュラー アクシオム エルエルシー | Ｓｏｓ遺伝子発現を調節するための組成物及び方法 |
| FR3128873A1 (fr) | 2021-11-10 | 2023-05-12 | Biophytis | Phytoecdysones et/ou dérivés de 20-hydroxyecdysone en combinaison avec un principe actif visant à restaurer l’expression SMN pour leur utilisation dans le traitement de l’amyotrophie spinale |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014110291A1 (en) | 2013-01-09 | 2014-07-17 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulation of smn2 splicing in a subject |
| WO2015161170A2 (en) * | 2014-04-17 | 2015-10-22 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulation of smn2 splicing in a subject |
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