KR102417684B1 - 디펩티딜 펩티다제 i 억제제로서의 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드 - Google Patents

디펩티딜 펩티다제 i 억제제로서의 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드 Download PDF

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KR102417684B1
KR102417684B1 KR1020167022665A KR20167022665A KR102417684B1 KR 102417684 B1 KR102417684 B1 KR 102417684B1 KR 1020167022665 A KR1020167022665 A KR 1020167022665A KR 20167022665 A KR20167022665 A KR 20167022665A KR 102417684 B1 KR102417684 B1 KR 102417684B1
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oxazepane
ethyl
cyano
carboxamide
phenyl
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KR20160111470A (ko
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한스 롤란드 뢴
스티븐 코놀리
스티븐 스왈로우
스테판 피오 칼슨
카를-요한 아우렐
존 프리티오프 폰텐
케빈 제임스 도일
아만다 제인 반 데 포엘
그레이엄 피터 존스
데이빗 윈 왓슨
재클린 앤 맥리치
니콜라스 존 팔머
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아스트라제네카 아베
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    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020167022665A 2014-01-24 2015-01-23 디펩티딜 펩티다제 i 억제제로서의 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드 Active KR102417684B1 (ko)

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Application Number Priority Date Filing Date Title
US201461931090P 2014-01-24 2014-01-24
US61/931,090 2014-01-24
PCT/GB2015/050155 WO2015110826A1 (en) 2014-01-24 2015-01-23 (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase i inhibitors

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KR20160111470A KR20160111470A (ko) 2016-09-26
KR102417684B1 true KR102417684B1 (ko) 2022-07-05

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US (18) US9522894B2 (OSRAM)
EP (4) EP3097086B1 (OSRAM)
JP (7) JP6469711B2 (OSRAM)
KR (1) KR102417684B1 (OSRAM)
CN (2) CN110483492B (OSRAM)
AP (1) AP2016009322A0 (OSRAM)
AR (1) AR099177A1 (OSRAM)
AU (4) AU2015208932C1 (OSRAM)
BR (1) BR112016016224B1 (OSRAM)
CA (1) CA2935625C (OSRAM)
CL (1) CL2016001889A1 (OSRAM)
CR (1) CR20160327A (OSRAM)
CY (2) CY1120049T1 (OSRAM)
DK (3) DK3323814T3 (OSRAM)
DO (1) DOP2016000175A (OSRAM)
EA (1) EA032794B1 (OSRAM)
ES (3) ES2808060T3 (OSRAM)
FI (1) FI3744714T3 (OSRAM)
HK (1) HK1225730B (OSRAM)
HR (3) HRP20180116T1 (OSRAM)
HU (3) HUE038274T2 (OSRAM)
IL (3) IL246614B (OSRAM)
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MX (1) MX368840B (OSRAM)
MY (1) MY194850A (OSRAM)
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NZ (2) NZ722063A (OSRAM)
PE (1) PE20161218A1 (OSRAM)
PH (1) PH12016501439B1 (OSRAM)
PL (3) PL3744714T3 (OSRAM)
PT (3) PT3744714T (OSRAM)
RS (3) RS56919B1 (OSRAM)
SG (2) SG10201701056QA (OSRAM)
SI (3) SI3323814T1 (OSRAM)
SM (3) SMT201800058T1 (OSRAM)
TW (1) TWI690517B (OSRAM)
UY (1) UY35963A (OSRAM)
WO (1) WO2015110826A1 (OSRAM)
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