KR102414886B1 - 니코틴아미드 리보사이드 및 그 유도체의 제조 방법 - Google Patents

니코틴아미드 리보사이드 및 그 유도체의 제조 방법 Download PDF

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KR102414886B1
KR102414886B1 KR1020217009552A KR20217009552A KR102414886B1 KR 102414886 B1 KR102414886 B1 KR 102414886B1 KR 1020217009552 A KR1020217009552 A KR 1020217009552A KR 20217009552 A KR20217009552 A KR 20217009552A KR 102414886 B1 KR102414886 B1 KR 102414886B1
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South Korea
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unsubstituted
substituted
compound
formula
optionally
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KR1020217009552A
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KR20210038718A (ko
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마리 미가우드
필립 레드패스
케리 크로시
마크 도허티
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더 퀸즈 유니버시티 오브 벨파스트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020217009552A 2013-07-29 2014-07-24 니코틴아미드 리보사이드 및 그 유도체의 제조 방법 KR102414886B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1313465.5 2013-07-29
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
PCT/EP2014/065971 WO2015014722A1 (fr) 2013-07-29 2014-07-24 Procédés de préparation de nicotinamide riboside et de ses dérivés
KR1020167005556A KR102303966B1 (ko) 2013-07-29 2014-07-24 니코틴아미드 리보사이드 및 그 유도체의 제조 방법

Related Parent Applications (1)

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KR1020167005556A Division KR102303966B1 (ko) 2013-07-29 2014-07-24 니코틴아미드 리보사이드 및 그 유도체의 제조 방법

Publications (2)

Publication Number Publication Date
KR20210038718A KR20210038718A (ko) 2021-04-07
KR102414886B1 true KR102414886B1 (ko) 2022-07-01

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KR1020167005556A KR102303966B1 (ko) 2013-07-29 2014-07-24 니코틴아미드 리보사이드 및 그 유도체의 제조 방법
KR1020217009552A KR102414886B1 (ko) 2013-07-29 2014-07-24 니코틴아미드 리보사이드 및 그 유도체의 제조 방법

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KR1020167005556A KR102303966B1 (ko) 2013-07-29 2014-07-24 니코틴아미드 리보사이드 및 그 유도체의 제조 방법

Country Status (14)

Country Link
US (6) US10000519B2 (fr)
EP (2) EP3027635B1 (fr)
JP (1) JP6208352B2 (fr)
KR (2) KR102303966B1 (fr)
CN (2) CN105636973B (fr)
AU (4) AU2014298629B2 (fr)
BR (1) BR112016001774B1 (fr)
CA (2) CA2918955C (fr)
ES (1) ES2652654T3 (fr)
GB (1) GB201313465D0 (fr)
HK (2) HK1218918A1 (fr)
MX (1) MX349969B (fr)
WO (1) WO2015014722A1 (fr)
ZA (1) ZA201802315B (fr)

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RU2016149767A (ru) * 2014-06-06 2018-07-16 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Аналоги никотинамидрибозида и фармацевтические композиции и их применение
ES2776395T3 (es) * 2014-07-24 2020-07-30 Grace W R & Co Forma cristalina de ribósido de nicotinamida
WO2016144660A1 (fr) * 2015-03-09 2016-09-15 W.R. Grace & Co.-Conn. Forme cristalline du nicotinamide riboside
JP7244163B2 (ja) 2015-03-16 2023-03-22 クロマデックス，インコーポレイテッド ニコチン酸リボシドまたはニコチンアミドリボシド組成物、その還元誘導体、およびその使用
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EA035664B1 (ru) 2015-08-05 2020-07-23 МЕТРО ИНТЕРНЭШНЛ БАЙОТЕК, ЭлЭлСи Производные никотинамидмононуклеотида и их применение для лечения заболевания или расстройства, связанного с биосинтезом над+
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
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US11248018B2 (en) 2016-02-23 2022-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent
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WO2017218580A1 (fr) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Procédés synthétiques pour la préparation de nicotinamide riboside et de composés apparentés
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
WO2018089830A1 (fr) 2016-11-11 2018-05-17 The Queen's University Of Belfast Synthèses efficaces et évolutives de nicotinoyle ribosides et de nicotinoyle ribosides réduits, de leurs dérivés modifiés, de leurs analogues phosphorylés, de leurs conjugués avec de l'adénylyle dinucléotide et de nouvelles formes cristallines de ceux-ci
MX2019006278A (es) 2016-11-29 2019-08-21 Univ Iowa Res Found Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
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SG11201912267SA (en) 2017-06-19 2020-01-30 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
US11629163B2 (en) * 2017-06-30 2023-04-18 Elysium Health, Inc. Methods of synthesizing nicotinamide riboside
US11414407B2 (en) 2017-12-22 2022-08-16 Elysium Health, Inc. Crystalline forms of nicotinamide riboside chloride
WO2019122084A1 (fr) 2017-12-22 2019-06-27 Stemtek Therapeutics, S.L. Procédé de préparation de dérivés de chlorure de nicotinamide riboside
US11180521B2 (en) 2018-01-30 2021-11-23 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学（上海）有限公司 杂环化合物的制备和纯化方法
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
WO2019226755A1 (fr) * 2018-05-22 2019-11-28 Jumpstart Fertility Pty Ltd Sels d'acides aminés de ribosides d'acide nicotinique utilisés comme agents anti-âge
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
EP3897666A2 (fr) 2018-12-17 2021-10-27 Mitopower LLC Composés nicotinyl riboside et leurs utilisations
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
WO2021030551A1 (fr) * 2019-08-14 2021-02-18 Metro International Biotech, Llc Composés et compositions pour la modulation différentielle de nicotinamide adénine dinucléotide
CN110642897B (zh) * 2019-09-27 2021-04-06 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN111153953A (zh) * 2020-01-07 2020-05-15 杭州洁汉化工有限公司 一种烟酰胺核糖氯化物的高效合成方法
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111647032B (zh) * 2020-06-29 2023-02-24 上海舒泽生物科技研究所 一种β-烟酰胺单核苷酸的合成方法
CN111848710A (zh) * 2020-08-20 2020-10-30 深圳市迪克曼科技开发有限公司 烟酰胺核糖及其还原态、盐的制备方法
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CN112851730B (zh) * 2021-01-08 2023-02-21 厦门瑞林药业有限公司 一种nmn中间体nr氯化物合成方法
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Journal of American Chemical Society, 2012년, 134(1), pp.367-374

Also Published As

Publication number Publication date
CN105636973B (zh) 2018-06-01
KR20210038718A (ko) 2021-04-07
HK1255037A1 (zh) 2019-08-02
ES2652654T3 (es) 2018-02-05
US20160168184A1 (en) 2016-06-16
US10000519B2 (en) 2018-06-19
AU2018211238A1 (en) 2018-08-16
JP6208352B2 (ja) 2017-10-04
MX349969B (es) 2017-08-23
US11981698B2 (en) 2024-05-14
US20180186824A1 (en) 2018-07-05
CA3192957A1 (fr) 2015-02-05
US20200291055A1 (en) 2020-09-17
AU2020201254A1 (en) 2020-03-12
US20220259250A1 (en) 2022-08-18
NZ716277A (en) 2021-03-26
ZA201802315B (en) 2023-02-22
EP3321274A1 (fr) 2018-05-16
CN105636973A (zh) 2016-06-01
CN108707174A (zh) 2018-10-26
MX2016001211A (es) 2016-10-28
AU2014298629A1 (en) 2016-02-11
AU2014298629B2 (en) 2018-08-16
US20240239831A1 (en) 2024-07-18
BR112016001774A8 (pt) 2020-01-21
US11584770B2 (en) 2023-02-21
WO2015014722A1 (fr) 2015-02-05
HK1218918A1 (zh) 2017-03-17
KR102303966B1 (ko) 2021-09-24
EP3027635A1 (fr) 2016-06-08
KR20160043974A (ko) 2016-04-22
BR112016001774A2 (pt) 2017-08-01
AU2020201254B2 (en) 2022-05-26
CA2918955A1 (fr) 2015-02-05
CA2918955C (fr) 2023-05-09
EP3027635B1 (fr) 2017-09-20
JP2016530248A (ja) 2016-09-29
AU2022203196A1 (en) 2022-06-02
BR112016001774B1 (pt) 2021-06-22
US10815262B2 (en) 2020-10-27
AU2022203196B2 (en) 2023-11-23
US20240101588A1 (en) 2024-03-28
GB201313465D0 (en) 2013-09-11

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