KR102378988B1 - 무칼로리 감미제 - Google Patents

무칼로리 감미제 Download PDF

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KR102378988B1
KR102378988B1 KR1020167033558A KR20167033558A KR102378988B1 KR 102378988 B1 KR102378988 B1 KR 102378988B1 KR 1020167033558 A KR1020167033558 A KR 1020167033558A KR 20167033558 A KR20167033558 A KR 20167033558A KR 102378988 B1 KR102378988 B1 KR 102378988B1
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rebaudioside
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udp
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KR20160147994A (ko
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구오홍 마오
벤카타 사이 프라카쉬 차투르베둘라
올리버 유
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코나겐 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
KR1020167033558A 2014-05-05 2015-05-05 무칼로리 감미제 Active KR102378988B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/269,435 2014-05-05
US14/269,435 US9522929B2 (en) 2014-05-05 2014-05-05 Non-caloric sweetener
PCT/US2015/029163 WO2015171555A1 (en) 2014-05-05 2015-05-05 A non-caloric sweetener

Publications (2)

Publication Number Publication Date
KR20160147994A KR20160147994A (ko) 2016-12-23
KR102378988B1 true KR102378988B1 (ko) 2022-03-28

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US (9) US9522929B2 (https=)
EP (3) EP4023660A1 (https=)
JP (1) JP6641357B2 (https=)
KR (1) KR102378988B1 (https=)
CN (1) CN106536536B (https=)
AR (1) AR100277A1 (https=)
AU (1) AU2015256232B2 (https=)
BR (1) BR112016025147B1 (https=)
CA (1) CA2982075A1 (https=)
DK (1) DK3140314T3 (https=)
ES (1) ES2750373T3 (https=)
HU (1) HUE045937T2 (https=)
MX (1) MX367883B (https=)
NZ (1) NZ725866A (https=)
WO (1) WO2015171555A1 (https=)
ZA (1) ZA201607592B (https=)

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US11155888B2 (en) 2010-03-12 2021-10-26 Purecircle Usa Inc. Stevia composition, production method and uses
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
EP4166010A1 (en) 2014-09-19 2023-04-19 PureCircle SDN BHD High-purity steviol glycosides
BR112017006163B1 (pt) 2014-10-03 2022-04-05 Conagen Inc Produto de consumo oral e método para adoçar o mesmo
CN107249356B (zh) 2014-12-17 2021-08-06 嘉吉公司 用于口服摄入或使用的甜菊醇糖苷化合物、组合物以及用于增强甜菊醇糖苷溶解度的方法
EP3250686A1 (en) * 2015-01-30 2017-12-06 Evolva SA Production of steviol glycosides in recombinant hosts
CN107666834B (zh) 2015-04-03 2021-08-24 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷
KR102569053B1 (ko) 2015-04-14 2023-08-21 코나겐 인크. 조작된 전체 세포 촉매를 사용한 비칼로리 감미료의 제조
US10494397B2 (en) * 2016-07-15 2019-12-03 Pepsico, Inc. Rebaudioside analogs
BR112019007504B1 (pt) 2016-10-14 2023-05-09 Conagen Inc Método de preparação de uma composição de glicosídeo de esteviol
BR112019008048A2 (pt) 2016-10-21 2019-07-02 Pepsico Inc método para preparar rebaudiosídeo n com o uso de método enzimático
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WO2018093196A1 (ko) * 2016-11-17 2018-05-24 서울대학교산학협력단 변형 류코노스톡속 균주를 이용한 스테비오사이드 배당체의 합성 방법 및 이에 의하여 제조된 신규한 스테비오사이드 배당체
KR101997597B1 (ko) * 2016-11-17 2019-07-08 서울대학교산학협력단 변형 류코노스톡속 균주를 이용한 스테비오사이드 배당체의 합성 방법 및 이에 의하여 제조된 신규한 스테비오사이드 배당체
KR102905512B1 (ko) 2017-02-03 2025-12-29 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법
AU2017402700A1 (en) * 2017-03-06 2019-10-17 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside D4 from rebaudioside E
CN110809408B (zh) 2017-06-30 2024-09-10 科纳根公司 通过β-葡糖苷酶水解甜菊醇糖苷
CN109423486B (zh) * 2017-08-29 2022-02-25 中国科学院分子植物科学卓越创新中心 新型udp-糖基转移酶及其应用
CN107446874B (zh) * 2017-09-25 2020-07-28 四川盈嘉合生科技有限公司 重组大肠杆菌及其在合成莱鲍迪苷d中的用途
CN111868252B (zh) 2018-03-12 2025-06-03 科纳根公司 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产
CN109415747B (zh) * 2018-05-25 2022-05-03 邦泰生物工程(深圳)有限公司 一种酶改质甜菊糖的制备方法和制备用酶及应用
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CN111344399B (zh) * 2018-11-16 2023-03-03 邦泰生物工程(深圳)有限公司 一种udp-葡萄糖基转移酶突变体、其应用及其制备莱鲍迪苷d的方法
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CN110878288B (zh) * 2019-12-09 2020-12-29 安徽农业大学 多肽、核酸及其在合成橙花叔醇糖苷上的应用
CN111378630A (zh) * 2020-04-09 2020-07-07 北京农学院 一种融合蛋白及其高效表达方法与应用
CN114045273B (zh) * 2021-11-15 2022-07-22 四川大学 糖基转移酶OsUGT91C1突变体及其应用
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CN117070487B (zh) * 2023-03-27 2024-12-24 浙江大学 茶树芦丁:尿苷二磷酸葡萄糖基转移酶基因及其应用
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WO2011028671A1 (en) 2009-09-04 2011-03-10 Redpoint Bio Corporation Sweetness enhancers including rebaudioside a or d
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AR100277A1 (es) 2016-09-21
US20200361978A1 (en) 2020-11-19
HUE045937T2 (hu) 2020-01-28
US10941174B2 (en) 2021-03-09
EP3140314B1 (en) 2019-07-31
JP6641357B2 (ja) 2020-02-05
US10597418B2 (en) 2020-03-24
CN106536536A (zh) 2017-03-22
EP3140314A4 (en) 2017-10-18
US20160207954A1 (en) 2016-07-21
DK3140314T3 (da) 2019-10-21
WO2015171555A1 (en) 2015-11-12
US20150315623A1 (en) 2015-11-05
US20180009835A1 (en) 2018-01-11
ES2750373T3 (es) 2020-03-25
EP3418288B1 (en) 2022-01-19
US20160208225A1 (en) 2016-07-21
US9522929B2 (en) 2016-12-20
US9765104B2 (en) 2017-09-19
US9988414B2 (en) 2018-06-05
BR112016025147A2 (pt) 2017-12-12
ZA201607592B (en) 2019-02-27
EP3418288A1 (en) 2018-12-26
US10654881B2 (en) 2020-05-19
KR20160147994A (ko) 2016-12-23
AU2015256232B2 (en) 2019-09-26
CN106536536B (zh) 2019-12-06
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US20160208303A1 (en) 2016-07-21
BR112016025147B1 (pt) 2021-11-03
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US10138263B2 (en) 2018-11-27
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