KR102353262B1 - 펩티드 생산용 융합 파트너 - Google Patents

펩티드 생산용 융합 파트너 Download PDF

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KR102353262B1
KR102353262B1 KR1020177017007A KR20177017007A KR102353262B1 KR 102353262 B1 KR102353262 B1 KR 102353262B1 KR 1020177017007 A KR1020177017007 A KR 1020177017007A KR 20177017007 A KR20177017007 A KR 20177017007A KR 102353262 B1 KR102353262 B1 KR 102353262B1
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seq
protein
fusion protein
kda
polypeptide
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KR20170085129A (ko
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다이앤 엠 리탈랙
아담 채프먼
토르벤 알 브럭
홍판 진
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피페넥스 인크.
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Assigned to 펠리칸 테크놀로지 홀딩스, 인크. reassignment 펠리칸 테크놀로지 홀딩스, 인크. 권리의 전부이전등록 Assignors: 피페넥스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21009—Enteropeptidase (3.4.21.9), i.e. enterokinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020177017007A 2014-12-01 2015-11-30 펩티드 생산용 융합 파트너 Active KR102353262B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086119P 2014-12-01 2014-12-01
US62/086,119 2014-12-01
PCT/US2015/063027 WO2016089782A1 (en) 2014-12-01 2015-11-30 Fusion partners for peptide production

Publications (2)

Publication Number Publication Date
KR20170085129A KR20170085129A (ko) 2017-07-21
KR102353262B1 true KR102353262B1 (ko) 2022-01-18

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US (2) US10118956B2 (https=)
EP (1) EP3227455B1 (https=)
JP (2) JP6817939B2 (https=)
KR (1) KR102353262B1 (https=)
CN (2) CN107532190B (https=)
AR (1) AR102865A1 (https=)
AU (1) AU2015355242B2 (https=)
CA (1) CA2966358C (https=)
DK (1) DK3227455T3 (https=)
ES (1) ES2952405T3 (https=)
MX (1) MX386884B (https=)
NZ (1) NZ732400A (https=)
RU (1) RU2017123283A (https=)
SG (1) SG11201704362VA (https=)
TW (1) TWI702289B (https=)
WO (1) WO2016089782A1 (https=)

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EP3701036A4 (en) 2017-10-27 2021-09-01 Pfenex Inc. PROCESS FOR PRODUCING ASPARAGINASE OF E. COLI
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KR102009709B1 (ko) * 2018-02-14 2019-08-12 주식회사 펩진 융합 폴리펩타이드를 이용하여 인간 부갑상선 호르몬 1-84를 생산하는 방법
KR102017542B1 (ko) * 2018-02-14 2019-09-03 주식회사 펩진 융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-2 또는 이의 유사체를 생산하는 방법
KR102017540B1 (ko) * 2018-02-14 2019-09-03 주식회사 펩진 융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-1 또는 이의 유사체를 생산하는 방법
CN108977423A (zh) * 2018-08-17 2018-12-11 集美大学 一种从猪肺中分离提纯血管紧张素转化酶的方法
KR102011291B1 (ko) * 2018-12-05 2019-10-21 주식회사 펩진 신규한 융합 폴리펩타이드 및 이를 이용하여 인간 부갑상선 호르몬 1-34를 생산하는 방법
CN113453677A (zh) 2018-12-13 2021-09-28 沪亚生物国际有限责任公司 用于治疗急性心房颤动的舒卡定施用
CN110305223B (zh) * 2019-06-26 2022-05-13 重庆派金生物科技有限公司 重组串联融合蛋白制备目标多肽的方法
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KR20210010368A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 글루카곤 유사 펩타이드-2 또는 이의 유사체 생산용 융합태그
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CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
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CN107532190B (zh) 2021-07-09
NZ732400A (en) 2021-07-30
CN113444183A (zh) 2021-09-28
JP2017536835A (ja) 2017-12-14
EP3227455B1 (en) 2023-07-12
US20190135889A1 (en) 2019-05-09
WO2016089782A1 (en) 2016-06-09
TW201629226A (zh) 2016-08-16
US10981968B2 (en) 2021-04-20
JP7148579B2 (ja) 2022-10-05
ES2952405T3 (es) 2023-10-31
EP3227455A1 (en) 2017-10-11
SG11201704362VA (en) 2017-06-29
BR112017011662A2 (pt) 2018-02-27
HK1245336A1 (en) 2018-08-24
AR102865A1 (es) 2017-03-29
AU2015355242A1 (en) 2017-06-22
MX2017006866A (es) 2017-11-15
JP2021003117A (ja) 2021-01-14
DK3227455T3 (da) 2023-08-21
US10118956B2 (en) 2018-11-06
CN107532190A (zh) 2018-01-02
CN113444183B (zh) 2025-06-17
AU2015355242B2 (en) 2020-10-08
EP3227455A4 (en) 2018-07-04
TWI702289B (zh) 2020-08-21
JP6817939B2 (ja) 2021-01-20
US20160159877A1 (en) 2016-06-09
KR20170085129A (ko) 2017-07-21
CA2966358C (en) 2021-12-07
RU2017123283A (ru) 2019-01-09
CA2966358A1 (en) 2016-06-09
MX386884B (es) 2025-03-19

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