KR102307389B1 - Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법 - Google Patents

Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법 Download PDF

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KR102307389B1
KR102307389B1 KR1020167011726A KR20167011726A KR102307389B1 KR 102307389 B1 KR102307389 B1 KR 102307389B1 KR 1020167011726 A KR1020167011726 A KR 1020167011726A KR 20167011726 A KR20167011726 A KR 20167011726A KR 102307389 B1 KR102307389 B1 KR 102307389B1
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dsrna
alas1
porphyria
nucleotides
delete delete
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KR20160079793A (ko
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브라이언 베텐코트
케빈 피츠제럴드
윌리엄 퀘르베스
로버트 제이. 데스닉
마키코 야스다
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알닐람 파마슈티칼스 인코포레이티드
이칸 스쿨 오브 메디슨 엣 마운트 시나이
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KR1020167011726A 2013-10-04 2014-10-03 Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법 Active KR102307389B1 (ko)

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KR1020217030663A KR102469850B1 (ko) 2013-10-04 2014-10-03 Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법

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US201361887288P 2013-10-04 2013-10-04
US61/887,288 2013-10-04
US201461983720P 2014-04-24 2014-04-24
US61/983,720 2014-04-24
PCT/US2014/059160 WO2015051318A1 (en) 2013-10-04 2014-10-03 Compositions and methods for inhibiting expression of the alas1 gene

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KR102307389B1 true KR102307389B1 (ko) 2021-09-30

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KR1020217030663A Active KR102469850B1 (ko) 2013-10-04 2014-10-03 Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법
KR1020227040207A Pending KR20220159478A (ko) 2013-10-04 2014-10-03 Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법

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KR1020227040207A Pending KR20220159478A (ko) 2013-10-04 2014-10-03 Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법

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US9133461B2 (en) 2012-04-10 2015-09-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the ALAS1 gene
ES2804510T3 (es) * 2013-10-04 2021-02-08 Alnylam Pharmaceuticals Inc Composiciones y métodos para inhibir la expresión del gen ALAS1
IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
WO2016061487A1 (en) 2014-10-17 2016-04-21 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
TW201718857A (zh) 2015-09-14 2017-06-01 艾爾妮蘭製藥公司 用於抑制alas1基因表現之組合物及方法
KR20240035907A (ko) 2016-11-23 2024-03-18 알닐람 파마슈티칼스 인코포레이티드 표적외 효과가 감소된 변형 rna 작용제
TW201930591A (zh) 2018-01-08 2019-08-01 瑞士商諾華公司 用於與嵌合抗原受體療法併用之免疫增強rna
IL295625A (en) * 2020-02-21 2022-10-01 Ionis Pharmaceuticals Inc Methods for reducing htt expression
WO2023060064A1 (en) 2021-10-06 2023-04-13 Alnylam Pharmaceuticals, Inc. Renal injury biomarkers as biomarkers for acute hepatic porphyria (ahp)
EP4646481A1 (en) * 2023-01-06 2025-11-12 Memorial Sloan-Kettering Cancer Center Methods for enhancing the efficacy of rnai therapy by targeting alas1/alas2
CN118460654B (zh) * 2024-07-10 2025-02-14 凯莱英医药集团（天津）股份有限公司 一种Givosiran的制备方法

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