HRP20200822T1 - Pripravci i postupci za inhibiciju ekspresije gena alas1 - Google Patents

Pripravci i postupci za inhibiciju ekspresije gena alas1 Download PDF

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Publication number
HRP20200822T1
HRP20200822T1 HRP20200822TT HRP20200822T HRP20200822T1 HR P20200822 T1 HRP20200822 T1 HR P20200822T1 HR P20200822T T HRP20200822T T HR P20200822TT HR P20200822 T HRP20200822 T HR P20200822T HR P20200822 T1 HRP20200822 T1 HR P20200822T1
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HR
Croatia
Prior art keywords
dsrna
porphyria
optionally
subject
cell
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HRP20200822TT
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English (en)
Croatian (hr)
Inventor
Brian Bettencourt
Kevin Fitzgerald
William Querbes
Robert J. Desnick
Makiko YASUDA
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Alnylam Pharmaceuticals, Inc.
Icahn School Of Medicine At Mount Sinai
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Application filed by Alnylam Pharmaceuticals, Inc., Icahn School Of Medicine At Mount Sinai filed Critical Alnylam Pharmaceuticals, Inc.
Publication of HRP20200822T1 publication Critical patent/HRP20200822T1/hr

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HRP20200822TT 2013-10-04 2014-10-03 Pripravci i postupci za inhibiciju ekspresije gena alas1 HRP20200822T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361887288P 2013-10-04 2013-10-04
US201461983720P 2014-04-24 2014-04-24
EP14800179.5A EP3052628B1 (en) 2013-10-04 2014-10-03 Compositions and methods for inhibiting expression of the alas1 gene
PCT/US2014/059160 WO2015051318A1 (en) 2013-10-04 2014-10-03 Compositions and methods for inhibiting expression of the alas1 gene

Publications (1)

Publication Number Publication Date
HRP20200822T1 true HRP20200822T1 (hr) 2020-08-07

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HRP20200822TT HRP20200822T1 (hr) 2013-10-04 2014-10-03 Pripravci i postupci za inhibiciju ekspresije gena alas1

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US (4) US10119143B2 (enExample)
EP (2) EP3052628B1 (enExample)
JP (3) JP6613227B2 (enExample)
KR (3) KR102307389B1 (enExample)
CN (1) CN105980559B (enExample)
AU (3) AU2014331604B2 (enExample)
BR (2) BR112016007226B1 (enExample)
CA (2) CA2925357C (enExample)
CL (2) CL2016000772A1 (enExample)
CR (1) CR20160195A (enExample)
CY (2) CY1122975T1 (enExample)
DK (1) DK3052628T3 (enExample)
DO (2) DOP2016000073A (enExample)
EA (1) EA036477B1 (enExample)
ES (1) ES2804510T3 (enExample)
GT (1) GT201600066A (enExample)
HR (1) HRP20200822T1 (enExample)
HU (2) HUE049227T2 (enExample)
IL (4) IL282747B2 (enExample)
LT (2) LT3052628T (enExample)
MX (2) MX390724B (enExample)
MY (2) MY183490A (enExample)
NL (1) NL301061I2 (enExample)
NO (1) NO2020029I1 (enExample)
NZ (2) NZ718995A (enExample)
PE (2) PE20161130A1 (enExample)
PH (1) PH12016500574A1 (enExample)
PL (1) PL3052628T3 (enExample)
PT (1) PT3052628T (enExample)
SG (2) SG11201602631XA (enExample)
SI (1) SI3052628T1 (enExample)
SM (1) SMT202000271T1 (enExample)
TN (1) TN2016000114A1 (enExample)
TW (3) TWI694080B (enExample)
UA (1) UA124961C2 (enExample)
WO (1) WO2015051318A1 (enExample)
ZA (2) ZA201602931B (enExample)

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Publication number Priority date Publication date Assignee Title
US9133461B2 (en) 2012-04-10 2015-09-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the ALAS1 gene
ES2804510T3 (es) * 2013-10-04 2021-02-08 Alnylam Pharmaceuticals Inc Composiciones y métodos para inhibir la expresión del gen ALAS1
IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
WO2016061487A1 (en) 2014-10-17 2016-04-21 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
TW201718857A (zh) 2015-09-14 2017-06-01 艾爾妮蘭製藥公司 用於抑制alas1基因表現之組合物及方法
KR20240035907A (ko) 2016-11-23 2024-03-18 알닐람 파마슈티칼스 인코포레이티드 표적외 효과가 감소된 변형 rna 작용제
TW201930591A (zh) 2018-01-08 2019-08-01 瑞士商諾華公司 用於與嵌合抗原受體療法併用之免疫增強rna
IL295625A (en) * 2020-02-21 2022-10-01 Ionis Pharmaceuticals Inc Methods for reducing htt expression
WO2023060064A1 (en) 2021-10-06 2023-04-13 Alnylam Pharmaceuticals, Inc. Renal injury biomarkers as biomarkers for acute hepatic porphyria (ahp)
EP4646481A1 (en) * 2023-01-06 2025-11-12 Memorial Sloan-Kettering Cancer Center Methods for enhancing the efficacy of rnai therapy by targeting alas1/alas2
CN118460654B (zh) * 2024-07-10 2025-02-14 凯莱英医药集团（天津）股份有限公司 一种Givosiran的制备方法

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