KR102287288B1 - 신규한 방법 - Google Patents

신규한 방법 Download PDF

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Publication number
KR102287288B1
KR102287288B1 KR1020167017585A KR20167017585A KR102287288B1 KR 102287288 B1 KR102287288 B1 KR 102287288B1 KR 1020167017585 A KR1020167017585 A KR 1020167017585A KR 20167017585 A KR20167017585 A KR 20167017585A KR 102287288 B1 KR102287288 B1 KR 102287288B1
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South Korea
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compound
formula
pharmaceutical composition
alkyl
acid
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Korean (ko)
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KR20160093055A (ko
Inventor
킴벌리 배노버
펭 리
샤론 메이츠
로버트 데이비스
로런스 피 웨노글
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인트라-셀룰라 써래피스, 인코퍼레이티드.
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Application filed by 인트라-셀룰라 써래피스, 인코퍼레이티드. filed Critical 인트라-셀룰라 써래피스, 인코퍼레이티드.
Priority to KR1020217012501A priority Critical patent/KR102373288B1/ko
Priority to KR1020217012502A priority patent/KR102372145B1/ko
Priority to KR1020217024479A priority patent/KR102421656B1/ko
Publication of KR20160093055A publication Critical patent/KR20160093055A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020167017585A 2013-12-03 2014-12-03 신규한 방법 Active KR102287288B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020217012501A KR102373288B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217012502A KR102372145B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217024479A KR102421656B1 (ko) 2013-12-03 2014-12-03 신규한 방법

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361911416P 2013-12-03 2013-12-03
US61/911,416 2013-12-03
US201461925607P 2014-01-09 2014-01-09
US61/925,607 2014-01-09
US201461975702P 2014-04-04 2014-04-04
US61/975,702 2014-04-04
US201462032326P 2014-08-01 2014-08-01
US62/032,326 2014-08-01
PCT/US2014/068443 WO2015085004A1 (en) 2013-12-03 2014-12-03 Novel methods

Related Child Applications (3)

Application Number Title Priority Date Filing Date
KR1020217024479A Division KR102421656B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217012501A Division KR102373288B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217012502A Division KR102372145B1 (ko) 2013-12-03 2014-12-03 신규한 방법

Publications (2)

Publication Number Publication Date
KR20160093055A KR20160093055A (ko) 2016-08-05
KR102287288B1 true KR102287288B1 (ko) 2021-08-06

Family

ID=53274093

Family Applications (8)

Application Number Title Priority Date Filing Date
KR1020217012501A Active KR102373288B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217012502A Active KR102372145B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020237014108A Pending KR20230058736A (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020167017585A Active KR102287288B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020227023990A Active KR102495941B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020237003673A Active KR102692169B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020247025920A Pending KR20240119197A (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217024479A Active KR102421656B1 (ko) 2013-12-03 2014-12-03 신규한 방법

Family Applications Before (3)

Application Number Title Priority Date Filing Date
KR1020217012501A Active KR102373288B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217012502A Active KR102372145B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020237014108A Pending KR20230058736A (ko) 2013-12-03 2014-12-03 신규한 방법

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020227023990A Active KR102495941B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020237003673A Active KR102692169B1 (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020247025920A Pending KR20240119197A (ko) 2013-12-03 2014-12-03 신규한 방법
KR1020217024479A Active KR102421656B1 (ko) 2013-12-03 2014-12-03 신규한 방법

Country Status (17)

Country Link
US (8) US9956227B2 (enExample)
EP (2) EP3666271A1 (enExample)
JP (5) JP6475727B2 (enExample)
KR (8) KR102373288B1 (enExample)
CN (2) CN105939712A (enExample)
AU (4) AU2014360452C1 (enExample)
BR (1) BR112016012781A2 (enExample)
CA (4) CA3205777A1 (enExample)
DK (1) DK3076967T3 (enExample)
ES (1) ES2893621T3 (enExample)
HU (1) HUE056496T2 (enExample)
IL (4) IL321987A (enExample)
MX (3) MX395458B (enExample)
PL (1) PL3076967T3 (enExample)
PT (1) PT3076967T (enExample)
RU (1) RU2682658C1 (enExample)
WO (1) WO2015085004A1 (enExample)

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US20240024334A1 (en) 2024-01-25
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US20190290655A1 (en) 2019-09-26
AU2019200301A1 (en) 2019-02-07
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US10960010B2 (en) 2021-03-30
CN114366741A (zh) 2022-04-19
BR112016012781A2 (pt) 2017-08-08
JP6475727B2 (ja) 2019-02-27
JP2023089113A (ja) 2023-06-27
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EP3076967B1 (en) 2021-07-28
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IL293523B1 (en) 2023-10-01
KR102421656B1 (ko) 2022-07-15
CA3205777A1 (en) 2015-06-11
US20180200256A1 (en) 2018-07-19
CN105939712A (zh) 2016-09-14
IL246002B (en) 2022-07-01
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US20190298730A1 (en) 2019-10-03
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EP3666271A1 (en) 2020-06-17
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