KR102237364B1 - 올레아놀산의 ｃ１７―헤테로아릴 유도체 및 그의 사용 방법 - Google Patents

올레아놀산의 ｃ１７―헤테로아릴 유도체 및 그의 사용 방법 Download PDF

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KR102237364B1
KR102237364B1 KR1020157009160A KR20157009160A KR102237364B1 KR 102237364 B1 KR102237364 B1 KR 102237364B1 KR 1020157009160 A KR1020157009160 A KR 1020157009160A KR 20157009160 A KR20157009160 A KR 20157009160A KR 102237364 B1 KR102237364 B1 KR 102237364B1
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disease
compound
disorder
compounds
och
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KR20150053982A (ko
Inventor
신 지앙
크리스토퍼 에프. 벤더
멜리언 비스닉
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리아타 파마슈티컬즈, 아이엔씨.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epidemiology (AREA)
  • Lubricants (AREA)
  • Steroid Compounds (AREA)
KR1020157009160A 2012-09-10 2013-09-10 올레아놀산의 ｃ１７―헤테로아릴 유도체 및 그의 사용 방법 Active KR102237364B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261699199P 2012-09-10 2012-09-10
US61/699,199 2012-09-10
PCT/US2013/059015 WO2014040056A1 (en) 2012-09-10 2013-09-10 C17-heteroaryl derivatives of oleanolic acid and methods of use thereof

Publications (2)

Publication Number Publication Date
KR20150053982A KR20150053982A (ko) 2015-05-19
KR102237364B1 true KR102237364B1 (ko) 2021-04-06

Family

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KR1020157009160A Active KR102237364B1 (ko) 2012-09-10 2013-09-10 올레아놀산의 ｃ１７―헤테로아릴 유도체 및 그의 사용 방법

Country Status (28)

Country Link
US (1) US20140088163A1 (enExample)
EP (1) EP2892911B1 (enExample)
JP (1) JP6272870B2 (enExample)
KR (1) KR102237364B1 (enExample)
CN (1) CN104768965B (enExample)
AU (1) AU2013312102B2 (enExample)
BR (1) BR112015005200B1 (enExample)
CA (1) CA2882417C (enExample)
CY (1) CY1119762T1 (enExample)
DK (1) DK2892911T3 (enExample)
EA (1) EA029069B1 (enExample)
ES (1) ES2644615T3 (enExample)
HR (1) HRP20171565T1 (enExample)
HU (1) HUE036797T2 (enExample)
IL (1) IL237638B (enExample)
IN (1) IN2015DN01547A (enExample)
LT (1) LT2892911T (enExample)
ME (1) ME02911B (enExample)
MX (1) MX366954B (enExample)
NZ (1) NZ705213A (enExample)
PL (1) PL2892911T3 (enExample)
PT (1) PT2892911T (enExample)
RS (1) RS56563B1 (enExample)
SG (1) SG11201501800UA (enExample)
SI (1) SI2892911T1 (enExample)
SM (1) SMT201700501T1 (enExample)
WO (1) WO2014040056A1 (enExample)
ZA (1) ZA201501203B (enExample)

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CN104739841B (zh) 2008-01-11 2018-06-01 里亚塔医药公司 合成三萜类化合物及用以治病之方法
KR101665042B1 (ko) 2008-04-18 2016-10-11 리타 파마슈티컬스 잉크. 소염성 골격군을 포함하는 화합물 및 사용 방법
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
JP5857068B2 (ja) 2010-12-17 2016-02-10 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーターとしてのピラゾリルおよびピリミジニル三環式エノン
DK2841445T3 (en) 2012-04-27 2017-09-11 Reata Pharmaceuticals Inc 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONMETHYL, POLYMORPHE FORMS THEREOF AND PROCEDURES FOR USING IT
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
BR112015005168A2 (pt) 2012-09-10 2017-08-15 Reata Pharmaceuticals Inc Derivados de c17-alcanodiila e alquenodiila de ácido oleanólico e métodos de uso dos mesmos
AR096046A1 (es) 2013-04-24 2015-12-02 Abbvie Inc Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso
NZ734292A (en) 2015-02-12 2022-09-30 Reata Pharmaceuticals Inc Imidazolyl tricyclic enones as antioxidant inflammation modulators
ES2865163T3 (es) 2015-09-23 2021-10-15 Reata Pharmaceuticals Inc Derivados de ácido oleanólico modificado en C4 para la inhibición de il-17 y otros usos
MA46749A (fr) 2016-11-08 2019-09-18 Reata Pharmaceuticals Inc Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier
CN106632574B (zh) * 2016-12-07 2018-05-29 广东天键生物科技有限公司 一种化合物、其制备方法及用途
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
RU2020113341A (ru) 2017-09-14 2021-10-15 Феникс Байотекнолоджи, Инк. Способ и композиция для лечения вирусной инфекции
AU2018334467B2 (en) 2017-09-14 2022-10-20 Phoenix Biotechnology, Inc. Method and improved neuroprotective composition for treating neurological conditions
JP7498122B2 (ja) 2018-06-15 2024-06-11 リアタ ファーマシューティカルズ インコーポレイテッド ＩＬ－１７およびＲＯＲγの阻害用のピラゾール化合物およびイミダゾール化合物
EP3810141A1 (en) 2018-06-20 2021-04-28 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
US20220017566A1 (en) * 2018-09-28 2022-01-20 Sichuan Haisco Pharmaceutical Co., Ltd. Terpinoid derivatives and uses thereof
US12344631B2 (en) * 2019-07-19 2025-07-01 Reata Pharmaceuticals, Inc. C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof
KR102464428B1 (ko) 2020-03-31 2022-11-04 피닉스 바이오테크놀러지 인코포레이티드. 코로나바이러스 감염 치료를 위한 방법 및 조성물
EP4009981B1 (en) 2020-03-31 2023-08-16 Phoenix Biotechnology, Inc. Method and compositions for treating coronavirus infection
JP7214696B2 (ja) * 2020-10-01 2023-01-30 一般財団法人 化学物質評価研究機構 新規ｉｎ ｖｉｔｒｏ皮膚感作性試験法
AU2021397631A1 (en) 2020-12-11 2023-07-20 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids for use in therapy
US20240140986A1 (en) 2021-01-18 2024-05-02 Reata Pharmaceuticals, Inc. Synthetic ursolic acid derivatives and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011518192A (ja) * 2008-04-18 2011-06-23 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７同族体化オレアノール酸誘導体

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US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
CA2485565A1 (en) * 2002-05-13 2004-08-05 Trustees Of Dartmouth College Inhibitors and methods of use thereof
CN104739841B (zh) 2008-01-11 2018-06-01 里亚塔医药公司 合成三萜类化合物及用以治病之方法
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
EP2279197B1 (en) 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
TR201909788T4 (tr) * 2011-03-11 2019-07-22 Reata Pharmaceuticals Inc C4-monometil triterpenoid türevleri ve bunların kullanım yöntemleri.
US9556222B2 (en) * 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011518192A (ja) * 2008-04-18 2011-06-23 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７同族体化オレアノール酸誘導体

Also Published As

Publication number Publication date
BR112015005200A2 (enExample) 2017-08-15
KR20150053982A (ko) 2015-05-19
MX366954B (es) 2019-07-31
ZA201501203B (en) 2021-08-25
PL2892911T3 (pl) 2018-03-30
JP2015529227A (ja) 2015-10-05
NZ705213A (en) 2018-07-27
HRP20171565T1 (hr) 2017-12-15
SMT201700501T1 (it) 2017-11-15
HUE036797T2 (hu) 2018-07-30
RS56563B1 (sr) 2018-02-28
MX2015003078A (es) 2015-07-14
LT2892911T (lt) 2017-11-10
IL237638A0 (en) 2015-04-30
AU2013312102A1 (en) 2015-03-12
AU2013312102B2 (en) 2018-03-08
IL237638B (en) 2020-04-30
CY1119762T1 (el) 2018-06-27
EP2892911B1 (en) 2017-08-30
EA029069B1 (ru) 2018-02-28
PT2892911T (pt) 2017-11-02
HK1211295A1 (en) 2016-05-20
BR112015005200B1 (pt) 2022-07-05
CN104768965A (zh) 2015-07-08
CA2882417C (en) 2021-04-20
SG11201501800UA (en) 2015-04-29
CA2882417A1 (en) 2014-03-13
ME02911B (me) 2018-10-20
WO2014040056A1 (en) 2014-03-13
DK2892911T3 (en) 2017-10-23
IN2015DN01547A (enExample) 2015-07-03
JP6272870B2 (ja) 2018-01-31
US20140088163A1 (en) 2014-03-27
EP2892911A1 (en) 2015-07-15
CN104768965B (zh) 2018-05-11
EA201590539A1 (ru) 2015-08-31
SI2892911T1 (sl) 2017-12-29
ES2644615T3 (es) 2017-11-29

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