KR102190009B1 - 비강내 덱스메데토미딘(dexmedetomidine) 조성물 및 그 사용방법 - Google Patents

비강내 덱스메데토미딘(dexmedetomidine) 조성물 및 그 사용방법 Download PDF

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KR102190009B1
KR102190009B1 KR1020147017624A KR20147017624A KR102190009B1 KR 102190009 B1 KR102190009 B1 KR 102190009B1 KR 1020147017624 A KR1020147017624 A KR 1020147017624A KR 20147017624 A KR20147017624 A KR 20147017624A KR 102190009 B1 KR102190009 B1 KR 102190009B1
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dexmedetomidine
minutes
administration
pharmaceutically acceptable
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KR20140107329A (ko
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제라딘 에이. 핸우드
랜달 제이. 마크
제이알. 존 조세핀 코랭
크리스토퍼 티. 샤르
찰스 알렉산더 프라이어
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바우닥스 바이오, 인코포레이티드
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Application filed by 바우닥스 바이오, 인코포레이티드 filed Critical 바우닥스 바이오, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147017624A 2011-12-11 2012-12-11 비강내 덱스메데토미딘(dexmedetomidine) 조성물 및 그 사용방법 Expired - Fee Related KR102190009B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161569255P 2011-12-11 2011-12-11
US61/569,255 2011-12-11
PCT/US2012/068988 WO2013090278A2 (en) 2011-12-11 2012-12-11 Intranasal dexmedetomidine compositions and methods of use thereof

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Publication Number Publication Date
KR20140107329A KR20140107329A (ko) 2014-09-04
KR102190009B1 true KR102190009B1 (ko) 2020-12-15

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KR1020147017624A Expired - Fee Related KR102190009B1 (ko) 2011-12-11 2012-12-11 비강내 덱스메데토미딘(dexmedetomidine) 조성물 및 그 사용방법

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US (2) US9795559B2 (https=)
EP (2) EP3406247A1 (https=)
JP (2) JP6268100B2 (https=)
KR (1) KR102190009B1 (https=)
CN (1) CN104470516A (https=)
AU (2) AU2012352528B9 (https=)
BR (1) BR112014019171A8 (https=)
CA (1) CA2858721C (https=)
CL (1) CL2014001515A1 (https=)
CO (1) CO7000773A2 (https=)
CR (1) CR20140318A (https=)
DO (1) DOP2014000123A (https=)
EC (1) ECSP14007644A (https=)
IL (1) IL232977B (https=)
MX (1) MX367286B (https=)
PE (1) PE20142314A1 (https=)
PH (1) PH12014501273A1 (https=)
RU (1) RU2692245C2 (https=)
SG (2) SG10201604653TA (https=)
WO (1) WO2013090278A2 (https=)

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CA2924190C (en) * 2013-10-07 2019-07-09 Teikoku Pharma Usa, Inc. Methods and compositions for treating withdrawal syndromes using non-sedative dexmedetomidine transdermal compositions
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WO2020123607A1 (en) 2018-12-11 2020-06-18 Satsuma Pharmaceuticals, Inc. Compositions, devices, and methods for treating or preventing headaches
CN111481506B (zh) * 2019-01-25 2023-01-24 江苏恒瑞医药股份有限公司 一种包含经鼻给药的右美托咪定组合物的药物制品
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CN116474219A (zh) * 2019-06-28 2023-07-25 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
CN112107544A (zh) * 2019-06-28 2020-12-22 四川普锐特药业有限公司 右美托咪定鼻喷剂、其制备方法及应用
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CN118948739A (zh) * 2020-06-08 2024-11-15 四川普锐特药业有限公司 右美托咪定滴鼻剂或鼻喷剂在助眠药物制备中的应用
WO2022147537A1 (en) * 2021-01-04 2022-07-07 Bioxcel Therapeutics, Inc. Dexmedetomidine treatment regimens
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CN113876776A (zh) * 2021-11-04 2022-01-04 江苏大学附属医院 一种复方鼻喷镇痛药剂及其制备方法
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MX2014006961A (es) 2014-09-22
EP2787970A2 (en) 2014-10-15
PH12014501273A1 (en) 2014-09-08
EP2787970B1 (en) 2018-04-11
DOP2014000123A (es) 2014-12-31
HK1203049A1 (en) 2015-10-16
RU2692245C2 (ru) 2019-06-24
CL2014001515A1 (es) 2014-12-05
CA2858721C (en) 2021-03-16
PE20142314A1 (es) 2015-01-23
CN104470516A (zh) 2015-03-25
AU2012352528A1 (en) 2014-07-10
US20130178465A1 (en) 2013-07-11
NZ626999A (en) 2016-07-29
KR20140107329A (ko) 2014-09-04
IL232977A0 (en) 2014-07-31
JP6505177B2 (ja) 2019-04-24
CR20140318A (es) 2014-10-28
WO2013090278A3 (en) 2014-12-24
BR112014019171A8 (pt) 2017-07-11
EP2787970A4 (en) 2015-10-28
SG10201604653TA (en) 2016-07-28
MX367286B (es) 2019-08-13
WO2013090278A2 (en) 2013-06-20
EP3406247A1 (en) 2018-11-28
AU2018200591B2 (en) 2018-11-29
US20180055764A1 (en) 2018-03-01
AU2018200591A1 (en) 2018-02-15
US9795559B2 (en) 2017-10-24
CA2858721A1 (en) 2013-06-20
JP2015513309A (ja) 2015-05-07
CO7000773A2 (es) 2014-07-21
BR112014019171A2 (https=) 2017-06-20
AU2012352528B2 (en) 2017-10-26
AU2012352528B9 (en) 2017-11-02
JP6268100B2 (ja) 2018-01-24
SG11201403094TA (en) 2014-10-30
IL232977B (en) 2019-01-31
ECSP14007644A (es) 2015-11-30
RU2014128343A (ru) 2016-01-27
JP2018030850A (ja) 2018-03-01
US10682311B2 (en) 2020-06-16

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