KR102113363B1 - Cdk4/6 억제제 및 b-raf 억제제의 제약 조합물 - Google Patents

Cdk4/6 억제제 및 b-raf 억제제의 제약 조합물 Download PDF

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KR102113363B1
KR102113363B1 KR1020157001594A KR20157001594A KR102113363B1 KR 102113363 B1 KR102113363 B1 KR 102113363B1 KR 1020157001594 A KR1020157001594 A KR 1020157001594A KR 20157001594 A KR20157001594 A KR 20157001594A KR 102113363 B1 KR102113363 B1 KR 102113363B1
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combination
compound
inhibitor
raf
cancer
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KR20150036146A (ko
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지오다노 카포니그로
다린 스튜어트
선규 김
앨리스 루
스콧 델라치
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노파르티스 아게
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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KR1020157001594A 2012-07-26 2013-07-25 Cdk4/6 억제제 및 b-raf 억제제의 제약 조합물 Active KR102113363B1 (ko)

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Application Number Priority Date Filing Date Title
US201261676134P 2012-07-26 2012-07-26
US61/676,134 2012-07-26
US201361830911P 2013-06-04 2013-06-04
US61/830,911 2013-06-04
PCT/US2013/051990 WO2014018725A1 (en) 2012-07-26 2013-07-25 Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor

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KR20150036146A KR20150036146A (ko) 2015-04-07
KR102113363B1 true KR102113363B1 (ko) 2020-05-21

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US (1) US9700557B2 (enExample)
EP (1) EP2877174B1 (enExample)
JP (1) JP6320379B2 (enExample)
KR (1) KR102113363B1 (enExample)
CN (1) CN104507474B (enExample)
AR (1) AR091876A1 (enExample)
AU (1) AU2013295771B2 (enExample)
CA (1) CA2874860C (enExample)
ES (1) ES2778059T3 (enExample)
IN (1) IN2015DN00376A (enExample)
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CN105753869B (zh) * 2015-04-01 2018-09-25 苏州晶云药物科技有限公司 一种cdk抑制剂和mek抑制剂的共晶及其制备方法
US10323035B2 (en) * 2015-04-01 2019-06-18 Crystal Pharmatech Co., Ltd. Co-crystal of a CDK inhibitor and an MEK inhibitor and process of preparation thereof
WO2017037574A1 (en) * 2015-08-28 2017-03-09 Novartis Ag Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer
CN105732642B (zh) * 2015-11-18 2018-09-25 苏州晶云药物科技有限公司 一种cdk抑制剂和mek抑制剂的共晶及其制备方法
UA125436C2 (uk) * 2016-06-03 2022-03-09 Еррей Біофарма, Інк. Фармацевтичні комбінації
AU2017315357B2 (en) * 2016-08-23 2022-12-01 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of hepatocellular carcinoma
KR102341660B1 (ko) 2016-09-19 2021-12-23 노파르티스 아게 Raf 억제제 및 erk 억제제를 포함하는 치료적 조합
WO2018081211A1 (en) * 2016-10-26 2018-05-03 Li George Y Deuterated 7-cyclopentyl-n, n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimdine-6-carboxamide
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
ES2952265T3 (es) 2017-05-02 2023-10-30 Novartis Ag Terapia combinada que comprende un inhibidor de Raf y trametinib
WO2018218633A1 (en) 2017-06-02 2018-12-06 Beijing Percans Oncology Co. Ltd. Combination therapies for treating cancers
PE20210121A1 (es) 2018-01-08 2021-01-19 G1 Therapeutics Inc Regimenes de dosificacion superior de g1t38
CA3089592A1 (en) 2018-02-15 2019-08-22 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
WO2019195959A1 (en) * 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
US11633401B2 (en) * 2018-07-06 2023-04-25 Memorial Sloan Kettering Cancer Center Combination therapy with MEK inhibitor and CDK4/6 inhibitor to treat pancreatic cancer
MX2021007477A (es) * 2018-12-20 2021-08-05 Novartis Ag Terapia de combinacion con un inhibidor de raf y un inhibidor de cdk4/6 para utilizar en el tratamiento del cancer.
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TW202114667A (zh) * 2019-09-11 2021-04-16 大陸商江蘇恒瑞醫藥股份有限公司 Mek抑制劑與cdk4/6抑制劑聯合在製備治療腫瘤的藥物中的用途
IL292161B2 (en) 2019-12-10 2025-04-01 Hoffmann La Roche New methylquinazolinone derivatives
US20240000789A1 (en) * 2020-05-12 2024-01-04 Novartis Ag Therapeutic combinations comprising a craf inhibitor
WO2023230554A1 (en) 2022-05-25 2023-11-30 Pfizer Inc. Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer
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AU2013295771A1 (en) 2014-12-11
MX2015001122A (es) 2015-04-08
BR112014033118A2 (pt) 2017-06-27
CN104507474A (zh) 2015-04-08
CA2874860C (en) 2020-06-23
RU2015106524A (ru) 2016-09-20
RU2685250C2 (ru) 2019-04-17
AR091876A1 (es) 2015-03-04
TW201412316A (zh) 2014-04-01
BR112014033118A8 (pt) 2023-01-31
WO2014018725A1 (en) 2014-01-30
JO3776B1 (ar) 2021-01-31
CN104507474B (zh) 2018-01-02
KR20150036146A (ko) 2015-04-07
AU2013295771B2 (en) 2016-08-11
EP2877174B1 (en) 2020-01-01
EP2877174A1 (en) 2015-06-03
IN2015DN00376A (enExample) 2015-06-12
TWI599357B (zh) 2017-09-21
JP6320379B2 (ja) 2018-05-09
ES2778059T3 (es) 2020-08-07
MX360045B (es) 2018-10-19
US9700557B2 (en) 2017-07-11
US20150164897A1 (en) 2015-06-18
HK1210721A1 (en) 2016-05-06
JP2015523397A (ja) 2015-08-13
CA2874860A1 (en) 2014-01-30

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