TWI599357B - 醫藥組合 - Google Patents
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- TWI599357B TWI599357B TW102126726A TW102126726A TWI599357B TW I599357 B TWI599357 B TW I599357B TW 102126726 A TW102126726 A TW 102126726A TW 102126726 A TW102126726 A TW 102126726A TW I599357 B TWI599357 B TW I599357B
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| CN112641787A (zh) | 2013-03-21 | 2021-04-13 | 诺华股份有限公司 | 包含B-Raf抑制剂和第二抑制剂的组合疗法 |
| JP2018502089A (ja) * | 2014-12-23 | 2018-01-25 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｒａｆ阻害剤及びａｕｒｏｒａキナーゼ阻害剤の組み合わせ |
| CN105753869B (zh) * | 2015-04-01 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
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| CN105732642B (zh) * | 2015-11-18 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
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| WO2019136451A1 (en) | 2018-01-08 | 2019-07-11 | G1 Therapeutics, Inc. | G1t38 superior dosage regimes |
| US11174252B2 (en) | 2018-02-15 | 2021-11-16 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| WO2019195959A1 (en) * | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
| US11633401B2 (en) * | 2018-07-06 | 2023-04-25 | Memorial Sloan Kettering Cancer Center | Combination therapy with MEK inhibitor and CDK4/6 inhibitor to treat pancreatic cancer |
| AU2019407159A1 (en) * | 2018-12-20 | 2021-07-15 | Novartis Ag | Combination therapy with a Raf inhibitor and a CKD4/6 inhibitor for use in the treatment of cancer |
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| TW202114667A (zh) * | 2019-09-11 | 2021-04-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | Mek抑制劑與cdk4/6抑制劑聯合在製備治療腫瘤的藥物中的用途 |
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- 2013-07-25 CN CN201380039725.5A patent/CN104507474B/zh active Active
- 2013-07-25 AU AU2013295771A patent/AU2013295771B2/en not_active Ceased
- 2013-07-25 RU RU2015106524A patent/RU2685250C2/ru active
- 2013-07-25 CA CA2874860A patent/CA2874860C/en active Active
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Non-Patent Citations (3)
| Title |
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| Ascierto Paolo A et al.;"The role of BRAF V600 mutation in melanoma";Journal of Translational Medicine,2012,vol.10,no.1,pages 85. * |
| Huillard Emmanuelle et al.;"Cooperative interactions of BRAFv600e kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy";Proceedings of the National Academy of Sciences,2012,vol.109,no.22,pages 8710-8715. * |
| Li Jing et al.;"Simultaneous Inhibition of MEK and CDK4 Leads to Potent Apoptosis in Human Melanoma Cells";Cancer Investigation,2010,vol.28,no.4,pages 350-356. * |
Also Published As
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|---|---|
| IN2015DN00376A (enExample) | 2015-06-12 |
| AU2013295771A1 (en) | 2014-12-11 |
| MX2015001122A (es) | 2015-04-08 |
| HK1210721A1 (en) | 2016-05-06 |
| RU2015106524A (ru) | 2016-09-20 |
| US20150164897A1 (en) | 2015-06-18 |
| US9700557B2 (en) | 2017-07-11 |
| ES2778059T3 (es) | 2020-08-07 |
| CN104507474B (zh) | 2018-01-02 |
| JP6320379B2 (ja) | 2018-05-09 |
| KR102113363B1 (ko) | 2020-05-21 |
| EP2877174A1 (en) | 2015-06-03 |
| AR091876A1 (es) | 2015-03-04 |
| KR20150036146A (ko) | 2015-04-07 |
| EP2877174B1 (en) | 2020-01-01 |
| CA2874860C (en) | 2020-06-23 |
| WO2014018725A1 (en) | 2014-01-30 |
| BR112014033118A2 (pt) | 2017-06-27 |
| RU2685250C2 (ru) | 2019-04-17 |
| JO3776B1 (ar) | 2021-01-31 |
| AU2013295771B2 (en) | 2016-08-11 |
| CN104507474A (zh) | 2015-04-08 |
| CA2874860A1 (en) | 2014-01-30 |
| JP2015523397A (ja) | 2015-08-13 |
| TW201412316A (zh) | 2014-04-01 |
| MX360045B (es) | 2018-10-19 |
| BR112014033118A8 (pt) | 2023-01-31 |
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