CN104507474B - CDK4/6抑制剂和B‑Raf抑制剂的药物组合 - Google Patents

CDK4/6抑制剂和B‑Raf抑制剂的药物组合 Download PDF

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CN104507474B
CN104507474B CN201380039725.5A CN201380039725A CN104507474B CN 104507474 B CN104507474 B CN 104507474B CN 201380039725 A CN201380039725 A CN 201380039725A CN 104507474 B CN104507474 B CN 104507474B
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combination
compound
raf
inhibitor
cancer
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CN104507474A (zh
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G·卡波尼格罗
D·斯图尔特
S·金
A·罗
S·德拉什
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Array Biopharma Inc
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Novartis AG
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Animal Behavior & Ethology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380039725.5A 2012-07-26 2013-07-25 CDK4/6抑制剂和B‑Raf抑制剂的药物组合 Active CN104507474B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261676134P 2012-07-26 2012-07-26
US61/676,134 2012-07-26
US201361830911P 2013-06-04 2013-06-04
US61/830,911 2013-06-04
PCT/US2013/051990 WO2014018725A1 (en) 2012-07-26 2013-07-25 Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor

Publications (2)

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CN104507474A CN104507474A (zh) 2015-04-08
CN104507474B true CN104507474B (zh) 2018-01-02

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US (1) US9700557B2 (enExample)
EP (1) EP2877174B1 (enExample)
JP (1) JP6320379B2 (enExample)
KR (1) KR102113363B1 (enExample)
CN (1) CN104507474B (enExample)
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AU (1) AU2013295771B2 (enExample)
CA (1) CA2874860C (enExample)
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WO2016106357A1 (en) * 2014-12-23 2016-06-30 Millennnium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
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WO2016155670A1 (zh) * 2015-04-01 2016-10-06 苏州晶云药物科技有限公司 一种cdk抑制剂和mek抑制剂的共晶及其制备方法
EP3340991A1 (en) * 2015-08-28 2018-07-04 Novartis AG Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer
CN105732642B (zh) * 2015-11-18 2018-09-25 苏州晶云药物科技有限公司 一种cdk抑制剂和mek抑制剂的共晶及其制备方法
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IL270224B1 (en) 2017-05-02 2024-04-01 Novartis Ag Combination therapy employing trametinib and a defined raf inhibitor
WO2018218633A1 (en) 2017-06-02 2018-12-06 Beijing Percans Oncology Co. Ltd. Combination therapies for treating cancers
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BR112020015431A2 (pt) 2018-02-15 2020-12-08 Nuvation Bio Inc. Compostos heterocíclicos como inibidores de quinase
WO2019195959A1 (en) * 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
WO2020010280A1 (en) * 2018-07-06 2020-01-09 Memorial Sloan Kettering Cancer Center Combination therapy with mek inhibitor and cdk4/6 inhibitor to treat pancreatic cancer
CN113453671A (zh) * 2018-12-20 2021-09-28 诺华股份有限公司 用于治疗癌症的Raf抑制剂和CDK4/6抑制剂的组合疗法
EP4563150A3 (en) 2019-05-13 2025-07-23 Novartis AG New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl) isonicotinamide as raf inhibitors for the treatment of cancer
WO2021047573A1 (zh) * 2019-09-11 2021-03-18 江苏恒瑞医药股份有限公司 一种mek抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤的药物中的用途
EP4483882A3 (en) 2019-12-10 2025-03-05 F. Hoffmann-La Roche AG New methylquinazolinone derivatives
JP2023525100A (ja) * 2020-05-12 2023-06-14 ノバルティス アーゲー Ｃｒａｆ阻害剤を含む治療的組み合わせ
WO2023230554A1 (en) 2022-05-25 2023-11-30 Pfizer Inc. Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer
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CN102186856A (zh) * 2008-08-22 2011-09-14 诺瓦提斯公司 作为cdk抑制剂的吡咯并嘧啶化合物
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TW201412316A (zh) 2014-04-01
JO3776B1 (ar) 2021-01-31
BR112014033118A2 (pt) 2017-06-27
AR091876A1 (es) 2015-03-04
JP6320379B2 (ja) 2018-05-09
KR20150036146A (ko) 2015-04-07
BR112014033118A8 (pt) 2023-01-31
ES2778059T3 (es) 2020-08-07
RU2685250C2 (ru) 2019-04-17
TWI599357B (zh) 2017-09-21
US9700557B2 (en) 2017-07-11
EP2877174B1 (en) 2020-01-01
MX360045B (es) 2018-10-19
MX2015001122A (es) 2015-04-08
AU2013295771B2 (en) 2016-08-11
US20150164897A1 (en) 2015-06-18
JP2015523397A (ja) 2015-08-13
EP2877174A1 (en) 2015-06-03
WO2014018725A1 (en) 2014-01-30
CN104507474A (zh) 2015-04-08
RU2015106524A (ru) 2016-09-20
AU2013295771A1 (en) 2014-12-11
KR102113363B1 (ko) 2020-05-21
CA2874860C (en) 2020-06-23
HK1210721A1 (en) 2016-05-06
IN2015DN00376A (enExample) 2015-06-12

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