KR102104296B1 - 종양성 질병들에 대한 치료 - Google Patents

종양성 질병들에 대한 치료 Download PDF

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Publication number
KR102104296B1
KR102104296B1 KR1020187029749A KR20187029749A KR102104296B1 KR 102104296 B1 KR102104296 B1 KR 102104296B1 KR 1020187029749 A KR1020187029749 A KR 1020187029749A KR 20187029749 A KR20187029749 A KR 20187029749A KR 102104296 B1 KR102104296 B1 KR 102104296B1
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South Korea
Prior art keywords
pharmaceutical composition
treatment
subject
tumor
administration
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KR1020187029749A
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English (en)
Korean (ko)
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KR20180116458A (ko
Inventor
존 시마드
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엑스바이오테크, 인크.
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Priority to KR1020207002089A priority Critical patent/KR102314003B1/ko
Publication of KR20180116458A publication Critical patent/KR20180116458A/ko
Application granted granted Critical
Publication of KR102104296B1 publication Critical patent/KR102104296B1/ko
Assigned to 얀센 바이오테크 인코포레이티드 reassignment 얀센 바이오테크 인코포레이티드 권리의 전부이전등록 Assignors: 엑스바이오테크 인코포레이티드
Assigned to 엑스바이오테크 인코포레이티드 reassignment 엑스바이오테크 인코포레이티드 권리의 전부이전등록 Assignors: 얀센 바이오테크 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020187029749A 2010-08-23 2011-08-23 종양성 질병들에 대한 치료 Active KR102104296B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020207002089A KR102314003B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US37609710P 2010-08-23 2010-08-23
US61/376,097 2010-08-23
US40675910P 2010-10-26 2010-10-26
US61/406,759 2010-10-26
US41118310P 2010-11-08 2010-11-08
US61/411,183 2010-11-08
US201161480635P 2011-04-29 2011-04-29
US61/480,635 2011-04-29
PCT/US2011/048747 WO2012027324A2 (en) 2010-08-23 2011-08-23 Treatment for neoplastic diseases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020177026757A Division KR101910760B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207002089A Division KR102314003B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료

Publications (2)

Publication Number Publication Date
KR20180116458A KR20180116458A (ko) 2018-10-24
KR102104296B1 true KR102104296B1 (ko) 2020-04-27

Family

ID=45594256

Family Applications (7)

Application Number Title Priority Date Filing Date
KR1020187029749A Active KR102104296B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020177026757A Active KR101910760B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020167013067A Ceased KR20160062200A (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020137007024A Ceased KR20130108305A (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020247029350A Active KR102748255B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020207002089A Active KR102314003B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020217032773A Ceased KR20210128021A (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료

Family Applications After (6)

Application Number Title Priority Date Filing Date
KR1020177026757A Active KR101910760B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020167013067A Ceased KR20160062200A (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020137007024A Ceased KR20130108305A (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020247029350A Active KR102748255B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020207002089A Active KR102314003B1 (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료
KR1020217032773A Ceased KR20210128021A (ko) 2010-08-23 2011-08-23 종양성 질병들에 대한 치료

Country Status (17)

Country Link
US (3) US10294296B2 (https=)
EP (3) EP3075394B1 (https=)
JP (5) JP6241932B2 (https=)
KR (7) KR102104296B1 (https=)
CN (3) CN103153340A (https=)
AU (1) AU2011293554B9 (https=)
DK (1) DK2608808T3 (https=)
ES (2) ES2856723T3 (https=)
IL (2) IL262856B (https=)
MX (2) MX388939B (https=)
NZ (1) NZ607472A (https=)
PH (2) PH12013500316A1 (https=)
PT (1) PT2608808T (https=)
RU (2) RU2679119C2 (https=)
SG (1) SG187853A1 (https=)
WO (1) WO2012027324A2 (https=)
ZA (1) ZA201301420B (https=)

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KR102167261B1 (ko) 2010-06-18 2020-10-20 엑스바이오테크, 인크. 관절염 치료
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US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
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US10975146B2 (en) 2018-06-29 2021-04-13 Cedars-Sinai Medical Center Interleukin-1 inhibition for combination treatment of pancreatic cancer
CA3095740A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin alpha (il-1a)
CA3095675A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)
CA3095676A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)
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