KR102083023B1 - 표면 기능화된 약물 운반 가능한 용출 마이크로스피어의 제조 방법 - Google Patents

표면 기능화된 약물 운반 가능한 용출 마이크로스피어의 제조 방법 Download PDF

Info

Publication number
KR102083023B1
KR102083023B1 KR1020187007546A KR20187007546A KR102083023B1 KR 102083023 B1 KR102083023 B1 KR 102083023B1 KR 1020187007546 A KR1020187007546 A KR 1020187007546A KR 20187007546 A KR20187007546 A KR 20187007546A KR 102083023 B1 KR102083023 B1 KR 102083023B1
Authority
KR
South Korea
Prior art keywords
microspheres
microsphere
chitosan
sulfonic acid
acrylamide
Prior art date
Application number
KR1020187007546A
Other languages
English (en)
Korean (ko)
Other versions
KR20180057622A (ko
Inventor
차이화 니
위엔롱 차오
강 스
리핑 장
Original Assignee
지앙난대학교
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 지앙난대학교 filed Critical 지앙난대학교
Publication of KR20180057622A publication Critical patent/KR20180057622A/ko
Application granted granted Critical
Publication of KR102083023B1 publication Critical patent/KR102083023B1/ko

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187007546A 2016-08-08 2016-11-04 표면 기능화된 약물 운반 가능한 용출 마이크로스피어의 제조 방법 KR102083023B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610650166.7A CN106110334B (zh) 2016-08-08 2016-08-08 一种表面功能化可载药洗脱微球的制备方法
CN2016106501667 2016-08-08
PCT/CN2016/104511 WO2018028058A1 (zh) 2016-08-08 2016-11-04 一种表面功能化可载药洗脱微球的制备方法

Publications (2)

Publication Number Publication Date
KR20180057622A KR20180057622A (ko) 2018-05-30
KR102083023B1 true KR102083023B1 (ko) 2020-02-28

Family

ID=57257628

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187007546A KR102083023B1 (ko) 2016-08-08 2016-11-04 표면 기능화된 약물 운반 가능한 용출 마이크로스피어의 제조 방법

Country Status (3)

Country Link
KR (1) KR102083023B1 (zh)
CN (1) CN106110334B (zh)
WO (1) WO2018028058A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108264612B (zh) * 2018-02-25 2020-10-09 温岭汉德高分子科技有限公司 一种用于单晶硅制绒的壳聚糖-聚2-丙烯酰胺基-2-甲基丙磺酸钠共聚物的制备方法
CN109464702B (zh) * 2019-01-14 2021-02-26 浙江瑞谷生物科技有限公司 含bmp-2的牙槽骨修复材料及其制备方法和应用
DE102019107633A1 (de) 2019-03-25 2020-10-29 Sphera Technology Gmbh Mehrkomponentensystem und Verfahren zur Herstellung eines Mehrkomponentensystems
CN110508259B (zh) * 2019-09-03 2022-02-15 晋江瑞碧科技有限公司 一种铜离子印迹复合磁性中空微球的制备方法
CN112168787B (zh) * 2020-09-24 2023-03-24 山东瑞安泰医疗技术有限公司 一种功能化可降解药物洗脱微球及其制备方法
DE102020124955A1 (de) 2020-09-24 2022-03-24 Sphera Technology Gmbh Elektronikeinheit mit einem integrierten Schaltkreis und Verfahren zu deren Herstellung
CN112316199B (zh) * 2020-11-16 2022-02-22 江南大学 一种改性羧甲基壳聚糖微球及其制备方法和应用
CN114191410A (zh) * 2021-11-15 2022-03-18 深圳北航新兴产业技术研究院 一种诊疗一体化双亲微球缓释微球的制备方法
CN114392270B (zh) * 2021-12-22 2024-07-23 苏州浩微生物医疗科技有限公司 一种壳聚糖微球、制备方法及其应用
CN114481616A (zh) * 2022-03-11 2022-05-13 四川三联新材料有限公司 一种加热卷烟用壳聚糖基膜复合材料的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102784112A (zh) 2011-05-19 2012-11-21 东华理工大学 壳聚糖接枝共聚物多孔缓释微球的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101125225A (zh) * 2007-08-10 2008-02-20 苏州迦俐生生物医药科技有限公司 微球型栓塞剂及其制备工艺
CN101775386A (zh) * 2010-01-26 2010-07-14 武汉工业学院 一种壳聚糖微球固定化胰蛋白酶的方法
CN102462664A (zh) * 2010-11-18 2012-05-23 华侨大学 一种磺酸基巯基壳聚糖介入栓塞化疗缓释微球及其制备方法
CN103304417B (zh) * 2012-03-15 2014-12-24 江南大学 一种双亲性共聚物改性壳聚糖复合物的制备及应用
CN103965403A (zh) * 2013-01-24 2014-08-06 孙亮 壳聚糖接枝amps的新方法
CN103977458B (zh) * 2014-05-28 2016-10-05 苏州恒瑞迦俐生生物医药科技有限公司 多羟基聚合体栓塞微球及其制备工艺
CN105273209B (zh) * 2014-06-09 2018-05-22 南京顺昌医药科技有限公司 一种改性壳聚糖与聚(2-丙烯酰胺-2-甲基丙磺酸)复合微球的制备
CN104208756A (zh) * 2014-08-29 2014-12-17 石家庄亿生堂医用品有限公司 一种羧甲基壳聚糖微球的制备方法
CN104258474B (zh) * 2014-10-15 2015-09-23 江南大学 一种含有离子交换功能基团的栓塞微球及其制备方法
CN104338185B (zh) * 2014-11-06 2019-04-05 石家庄亿生堂医用品有限公司 一种羧甲基壳聚糖微球栓塞剂及其制备方法
CN104474575B (zh) * 2014-12-03 2017-06-30 广州肽莱医药科技有限公司 共价交联形成的壳聚糖止血材料及其制备方法
CN104548123B (zh) * 2014-12-11 2017-10-10 江南大学 一种酰化改性明胶栓塞微球的制备
CN107321326A (zh) * 2017-07-03 2017-11-07 重庆大学 阴离子聚合物接枝壳聚糖磁性复合微球及制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102784112A (zh) 2011-05-19 2012-11-21 东华理工大学 壳聚糖接枝共聚物多孔缓释微球的制备方法

Also Published As

Publication number Publication date
WO2018028058A1 (zh) 2018-02-15
CN106110334B (zh) 2019-11-15
CN106110334A (zh) 2016-11-16
KR20180057622A (ko) 2018-05-30

Similar Documents

Publication Publication Date Title
KR102083023B1 (ko) 표면 기능화된 약물 운반 가능한 용출 마이크로스피어의 제조 방법
Chen et al. Recent advances in epsilon-poly-L-lysine and L-lysine-based dendrimer synthesis, modification, and biomedical applications
Zhu et al. Responsive hydrogels based on triggered click reactions for liver cancer
Xue et al. Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro
CN106693040A (zh) 一种可载药聚乙烯醇洗脱微球的制备方法
JP4991563B2 (ja) 胆汁酸−キトサン複合体内部に疎水性抗癌剤が封入された剤形及びその製造方法
CN112603908B (zh) 一种基于氨基酸聚合物的纳米载药体系及其制备方法和应用
TW201225976A (en) The synthesis of a new-type chitosan-based hybrid macromolecule and a method for producing or using themacromolecule
CN107952079A (zh) 一种联合给药的热致凝胶缓释注射剂及其制备方法
US20230172859A1 (en) Drug-loaded microbead compositions, embolization compositions and associated methods
Hu et al. Thermosensitive PNIPAM-based hydrogel crosslinked by composite nanoparticles as rapid wound-healing dressings
CN113209291A (zh) 一种用于肿瘤化疗与光热治疗联合治疗的纳米载体及其制备方法和应用
CN103655484B (zh) 一种利用自组装技术制备紫杉醇缓释微球的方法及其产品
KR20030015926A (ko) 자기집합체를 형성하는 항암제-키토산 복합체 및 그의제조방법
CN113651959B (zh) 一种基于氨基酸-羟基酸共聚物的纳米载药体系及其制备方法和应用
CN104666247A (zh) 肝素修饰的可断键阿霉素脂质体制剂及其制备方法
JP2022501365A (ja) ドラッグデリバリーのための多孔質生体吸収性放射線不透過性塞栓ミクロスフェア
Cheng et al. Injectable hydrogels as emerging drug-delivery platforms for tumor therapy
CN112546025B (zh) 一种Ce6@CMCS-DSP-IPI549抗肿瘤纳米传递系统的制备方法
Wong et al. Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery
Dashti et al. Co-delivery of carboplatin and doxorubicin using ZIF-8 coated chitosan-poly (N-isopropyl acrylamide) nanoparticles through a dual pH/thermo responsive strategy to breast cancer cells
CN110511387A (zh) 透明质酸-g-聚酪氨酸-硫辛酸共聚物、聚多肽纳米粒及其制备方法与应用
Ahmadi et al. Smart nanogels in cancer therapy
CN113827724B (zh) 载药普鲁士蓝@锰纤维蛋白复合凝胶及制备方法、应用
CN113018276B (zh) 一种增强声动力治疗的肺癌靶向自组装纳米药物及其制备与应用

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant