KR102078530B1 - 피리돈 유도체들 - Google Patents

피리돈 유도체들 Download PDF

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KR102078530B1
KR102078530B1 KR1020147020852A KR20147020852A KR102078530B1 KR 102078530 B1 KR102078530 B1 KR 102078530B1 KR 1020147020852 A KR1020147020852 A KR 1020147020852A KR 20147020852 A KR20147020852 A KR 20147020852A KR 102078530 B1 KR102078530 B1 KR 102078530B1
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South Korea
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group
compound
oxo
phenyl
dihydropyridine
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Expired - Fee Related
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Korean (ko)
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KR20140117439A (ko
Inventor
히토시 오키
마사히로 오타
고스케 다케우치
히데아키 와타나베
아키다케 야마구치
요시히로 시바타
유이치 도미나가
다케시 짐보
게이지로 고바야시
가츠히로 고바야시
다이스케 후카츠
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다이이찌 산쿄 가부시키가이샤
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Publication of KR20140117439A publication Critical patent/KR20140117439A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020147020852A 2012-01-31 2013-01-30 피리돈 유도체들 Expired - Fee Related KR102078530B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012017971 2012-01-31
JPJP-P-2012-017971 2012-01-31
US201261746039P 2012-12-26 2012-12-26
US61/746,039 2012-12-26
PCT/JP2013/052111 WO2013115280A1 (ja) 2012-01-31 2013-01-30 ピリドン誘導体

Publications (2)

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KR20140117439A KR20140117439A (ko) 2014-10-07
KR102078530B1 true KR102078530B1 (ko) 2020-02-18

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Country Link
US (1) US8933103B2 (https=)
EP (1) EP2810937B1 (https=)
JP (1) JP6006241B2 (https=)
KR (1) KR102078530B1 (https=)
CN (1) CN104185627B (https=)
AU (1) AU2013216006B2 (https=)
BR (1) BR112014018702B1 (https=)
CA (1) CA2863515C (https=)
CO (1) CO7071126A2 (https=)
CY (1) CY1118656T1 (https=)
DK (1) DK2810937T3 (https=)
ES (1) ES2617484T3 (https=)
HR (1) HRP20170303T1 (https=)
HU (1) HUE031624T2 (https=)
IL (1) IL233863A (https=)
LT (1) LT2810937T (https=)
MX (1) MX351812B (https=)
MY (1) MY165215A (https=)
NZ (1) NZ627586A (https=)
PH (1) PH12014501719B1 (https=)
PL (1) PL2810937T3 (https=)
PT (1) PT2810937T (https=)
RS (1) RS55728B1 (https=)
RU (1) RU2632885C2 (https=)
SG (1) SG11201404505PA (https=)
SI (1) SI2810937T1 (https=)
SM (2) SMT201700065T1 (https=)
TW (1) TWI537259B (https=)
WO (1) WO2013115280A1 (https=)
ZA (1) ZA201405486B (https=)

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KR102483020B1 (ko) 2016-03-28 2023-01-04 인사이트 코포레이션 Tam 저해제로서의 피롤로트리아진 화합물
CN108250200A (zh) * 2016-12-28 2018-07-06 中国科学院上海药物研究所 一种具有Axl抑制活性的化合物及其制备和应用
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ES2985569T3 (es) * 2018-08-24 2024-11-06 Transthera Sciences Nanjing Inc Nuevo inhibidor de derivado de quinolina
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CN112625026B (zh) * 2019-09-24 2022-09-09 药捷安康(南京)科技股份有限公司 Tam家族激酶抑制剂的喹啉衍生物
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BR112022010082A2 (pt) * 2019-11-26 2022-08-30 Univ Texas Composto de fórmula estrutural i ou sal do mesmo, composição farmacêutica, uso do composto e uso da composição farmacêutica
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PL2810937T3 (pl) 2017-07-31
KR20140117439A (ko) 2014-10-07
PH12014501719B1 (en) 2019-07-17
LT2810937T (lt) 2017-02-10
TWI537259B (zh) 2016-06-11
CY1118656T1 (el) 2017-07-12
JP6006241B2 (ja) 2016-10-12
US20130281428A1 (en) 2013-10-24
EP2810937B1 (en) 2016-11-30
EP2810937A4 (en) 2015-07-22
RU2014135401A (ru) 2016-03-20
SMT201700065B (it) 2017-03-08
CA2863515C (en) 2018-02-27
SG11201404505PA (en) 2014-10-30
IL233863A (en) 2017-08-31
HK1203504A1 (en) 2015-10-30
US8933103B2 (en) 2015-01-13
RS55728B1 (sr) 2017-07-31
SMT201700065T1 (it) 2017-03-08
CN104185627B (zh) 2018-01-12
HRP20170303T1 (hr) 2017-04-21
CA2863515A1 (en) 2013-08-08
IL233863A0 (en) 2014-09-30
BR112014018702B1 (pt) 2021-12-14
PT2810937T (pt) 2017-03-03
BR112014018702A2 (https=) 2017-06-20
BR112014018702A8 (pt) 2017-07-11
RU2632885C2 (ru) 2017-10-11
PH12014501719A1 (en) 2014-11-10
AU2013216006B2 (en) 2017-06-08
HUE031624T2 (en) 2017-07-28
AU2013216006A1 (en) 2014-08-28
TW201335148A (zh) 2013-09-01
MX351812B (es) 2017-10-27
WO2013115280A1 (ja) 2013-08-08
MX2014009246A (es) 2014-10-14
JPWO2013115280A1 (ja) 2015-05-11
MY165215A (en) 2018-03-09
DK2810937T3 (en) 2017-03-13
NZ627586A (en) 2016-08-26
CO7071126A2 (es) 2014-09-30
ES2617484T3 (es) 2017-06-19
ZA201405486B (en) 2015-11-25
EP2810937A1 (en) 2014-12-10
CN104185627A (zh) 2014-12-03

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