KR101931822B1 - 아르기나아제의 억제제와 그것의 치료적 적용 - Google Patents

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Publication number

KR101931822B1

KR101931822B1 KR1020127030178A KR20127030178A KR101931822B1 KR 101931822 B1 KR101931822 B1 KR 101931822B1 KR 1020127030178 A KR1020127030178 A KR 1020127030178A KR 20127030178 A KR20127030178 A KR 20127030178A KR 101931822 B1 KR101931822 B1 KR 101931822B1

Authority

KR

South Korea

Prior art keywords

alkylene

delete delete

group

aryl

alkyl

Prior art date

2010-04-22

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• 102000004452 Arginase Human genes 0.000 title abstract description 29
• 108700024123 Arginases Proteins 0.000 title abstract description 29
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• -1 -OH Chemical group 0.000 claims description 287
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• 229920006395 saturated elastomer Polymers 0.000 claims description 101
• 125000003118 aryl group Chemical group 0.000 claims description 79
• 125000001072 heteroaryl group Chemical group 0.000 claims description 72
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 60
• 238000006243 chemical reaction Methods 0.000 claims description 59
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 51
• 150000003839 salts Chemical class 0.000 claims description 45
• 125000001424 substituent group Chemical group 0.000 claims description 43
• 125000000217 alkyl group Chemical group 0.000 claims description 33
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• 125000002947 alkylene group Chemical group 0.000 claims description 26
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 24
• 125000006588 heterocycloalkylene group Chemical group 0.000 claims description 23
• 239000001257 hydrogen Substances 0.000 claims description 20
• 239000003814 drug Substances 0.000 claims description 19
• 229910052760 oxygen Inorganic materials 0.000 claims description 16
• 238000011282 treatment Methods 0.000 claims description 16
• 125000004450 alkenylene group Chemical group 0.000 claims description 13
• 229910052717 sulfur Inorganic materials 0.000 claims description 13
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 12
• ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 12
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
• 229910052796 boron Inorganic materials 0.000 claims description 12
• 125000002993 cycloalkylene group Chemical group 0.000 claims description 12
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 11
• 125000005842 heteroatom Chemical group 0.000 claims description 11
• 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims description 8
• 125000004419 alkynylene group Chemical group 0.000 claims description 8
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
• 238000004519 manufacturing process Methods 0.000 claims description 8
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 7
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• 101710186578 Arginase-2, mitochondrial Proteins 0.000 claims description 7
• 125000004103 aminoalkyl group Chemical group 0.000 claims description 7
• 229910052736 halogen Inorganic materials 0.000 claims description 7
• 150000002431 hydrogen Chemical class 0.000 claims description 7
• 125000004104 aryloxy group Chemical group 0.000 claims description 6
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
• 210000004027 cell Anatomy 0.000 claims description 6
• 150000002367 halogens Chemical group 0.000 claims description 6
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
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• 125000005843 halogen group Chemical group 0.000 claims description 5
• 125000000623 heterocyclic group Chemical group 0.000 claims description 5
• 125000003107 substituted aryl group Chemical group 0.000 claims description 5
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 4
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• 125000000304 alkynyl group Chemical group 0.000 claims description 4
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• 125000004043 oxo group Chemical group O=* 0.000 claims description 4
• 230000029663 wound healing Effects 0.000 claims description 4
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 3
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• 238000002347 injection Methods 0.000 claims description 3
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• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 2
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 2
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• 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims 2
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• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
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• 108700014121 Pyruvate Kinase Deficiency of Red Cells Proteins 0.000 claims 1
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• 241000223109 Trypanosoma cruzi Species 0.000 claims 1
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• 208000005980 beta thalassemia Diseases 0.000 claims 1
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• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
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• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
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• 238000004040 coloring Methods 0.000 claims 1
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• 238000001565 modulated differential scanning calorimetry Methods 0.000 claims 1
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