SG10201503168VA - Inhibitors of arginase and their therapeutic applications - Google Patents
Inhibitors of arginase and their therapeutic applicationsInfo
- Publication number
- SG10201503168VA SG10201503168VA SG10201503168VA SG10201503168VA SG10201503168VA SG 10201503168V A SG10201503168V A SG 10201503168VA SG 10201503168V A SG10201503168V A SG 10201503168VA SG 10201503168V A SG10201503168V A SG 10201503168VA SG 10201503168V A SG10201503168V A SG 10201503168VA
- Authority
- SG
- Singapore
- Prior art keywords
- arginase
- inhibitors
- therapeutic applications
- therapeutic
- applications
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32689210P | 2010-04-22 | 2010-04-22 | |
| US41320210P | 2010-11-12 | 2010-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201503168VA true SG10201503168VA (en) | 2015-06-29 |
Family
ID=44072631
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012077970A SG184956A1 (en) | 2010-04-22 | 2011-04-20 | Inhibitors of arginase and their therapeutic applications |
| SG10201503168VA SG10201503168VA (en) | 2010-04-22 | 2011-04-20 | Inhibitors of arginase and their therapeutic applications |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012077970A SG184956A1 (en) | 2010-04-22 | 2011-04-20 | Inhibitors of arginase and their therapeutic applications |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9040703B2 (en) |
| EP (1) | EP2560978B1 (en) |
| JP (1) | JP5898177B2 (en) |
| KR (1) | KR101931822B1 (en) |
| CN (2) | CN104876955B (en) |
| AU (1) | AU2011242794B2 (en) |
| BR (1) | BR112012027034B1 (en) |
| CA (1) | CA2796867C (en) |
| ES (1) | ES2729936T3 (en) |
| HK (1) | HK1213901A1 (en) |
| IL (1) | IL222484A0 (en) |
| MX (2) | MX338114B (en) |
| MY (1) | MY162535A (en) |
| NZ (1) | NZ603364A (en) |
| RU (1) | RU2586219C2 (en) |
| SG (2) | SG184956A1 (en) |
| WO (1) | WO2011133653A1 (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2729936T3 (en) | 2010-04-22 | 2019-11-07 | Mars Inc | Arginase inhibitors and their therapeutic applications |
| PL2632927T3 (en) * | 2010-10-26 | 2016-09-30 | Boronates as arginase inhibitors | |
| US8894970B2 (en) * | 2010-12-31 | 2014-11-25 | Corridor Pharmaceuticals, Inc. | Arginase inhibitors and methods of use thereof |
| PL2707101T3 (en) | 2011-05-12 | 2019-10-31 | Proteostasis Therapeutics Inc | Proteostasis regulators |
| MX343534B (en) * | 2011-10-19 | 2016-11-09 | Mars Inc | Inhibitors of arginase and their therapeutic applications. |
| IN2014DN09678A (en) * | 2012-04-18 | 2015-07-31 | Mars Inc | |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| AU2015249374A1 (en) * | 2014-04-24 | 2016-12-01 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
| CN107001391B (en) | 2014-10-01 | 2020-11-27 | 默克专利股份公司 | Boronic acid derivatives |
| PL410665A1 (en) | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Arginase inhibitors and their therapeutical applications |
| MX2017016868A (en) | 2015-06-23 | 2018-09-06 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity. |
| KR102434308B1 (en) | 2015-10-30 | 2022-08-19 | 칼리테라 바이오사이언시즈, 인코포레이티드 | Compositions and methods for inhibiting arginine activity |
| PL417066A1 (en) * | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Arginase inhibitors and their therapeutical applications |
| KR20190104521A (en) | 2016-11-08 | 2019-09-10 | 칼리테라 바이오사이언시즈, 인코포레이티드 | Arginase Inhibitor Combination Therapies |
| ES2881395T3 (en) | 2016-12-22 | 2021-11-29 | Calithera Biosciences Inc | Compositions and Methods for Inhibiting Arginase Activity |
| CN108794517B (en) * | 2017-04-27 | 2021-03-30 | 南京谷睿生物科技有限公司 | Arginase inhibitor and preparation method and application thereof |
| BR112019023582A2 (en) | 2017-05-12 | 2020-06-02 | Calithera Biosciences Inc. | METHOD OF PREPARING (3R, 4S) -3-ACETAMIDO-4-ALYL-N- (TERC-BUTYL) PIRROLIDIN-3-CARBOXAMIDE |
| CR20200418A (en) * | 2018-02-17 | 2020-10-27 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| EP3765006A4 (en) * | 2018-03-13 | 2022-02-23 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| RU2684781C1 (en) * | 2018-03-21 | 2019-04-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Analgesing and antiviral agent based on substituted 2-[1-(1h-benzimidazol-2-yl)-3-phenyl-1h-1,2,4-triazole-5-yl]propane acid |
| WO2019186497A1 (en) | 2018-03-29 | 2019-10-03 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
| CN111770756B (en) * | 2018-04-27 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | Non-natural amino acid derivative, pharmaceutical composition containing same, and preparation method and application thereof |
| WO2019245890A1 (en) | 2018-06-20 | 2019-12-26 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| CN112584900A (en) * | 2018-08-22 | 2021-03-30 | 阿斯利康(瑞典)有限公司 | Arginase inhibitors and methods of use thereof |
| RU2695333C1 (en) * | 2018-09-24 | 2019-07-23 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Method for preventing ischemia-reperfusion renal injuries with an inhibitor of arginase ii in experiment |
| WO2020102646A2 (en) * | 2018-11-16 | 2020-05-22 | Arcus Biosciences, Inc. | Inhibitors of arg1 and/or arg2 |
| EP3883938A1 (en) * | 2018-11-21 | 2021-09-29 | Praxis Biotech LLC | Inhibitors of arginase |
| RS64781B1 (en) * | 2019-02-08 | 2023-11-30 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| CN112110944B (en) * | 2019-06-21 | 2022-02-11 | 南京谷睿生物科技有限公司 | Compound and preparation method and application thereof |
| MX2022000904A (en) * | 2019-07-23 | 2022-05-02 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof. |
| TW202228720A (en) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | Arginase inhibitors and methods of use thereof |
| CN115925680B (en) * | 2022-12-02 | 2024-01-23 | 浙江工业大学 | Trifluoromethyl-containing pyridine compound and preparation method and application thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1009890A (en) | 1911-02-09 | 1911-11-28 | Michael F Brauer | Dumping attachment for headers. |
| US1006597A (en) | 1911-05-26 | 1911-10-24 | Rail Joint Co | Insulated rail-joint. |
| US1014369A (en) | 1911-06-26 | 1912-01-09 | John P Buengers | Kite. |
| CA2305703A1 (en) | 1997-10-10 | 1999-04-22 | David W. Christianson | Compositions and methods for inhibiting arginase activity |
| US20040063666A1 (en) * | 1998-10-09 | 2004-04-01 | David Christianson | Compositions for inhibiting arginase activity |
| WO2002004465A1 (en) | 2000-07-06 | 2002-01-17 | Fal Diagnostics | Methods and kits for the detection of arginine compounds |
| AU2003218099A1 (en) * | 2002-03-12 | 2003-09-29 | Lsu Medical Center | Modulation of the immune response through the manipulation of arginine levels |
| CA2431080A1 (en) | 2003-06-02 | 2004-12-02 | Catherine Adele O'brien | Enhancement of anticancer immunity through inhibition of arginase |
| GB0405267D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
| WO2007005620A2 (en) | 2005-07-01 | 2007-01-11 | The Johns Hopkins University | Arginase ii: a target treatment of aging heart and heart failure |
| CN101755130B (en) | 2007-07-12 | 2012-10-17 | 山洋电气株式会社 | Dual reversal-rotating type axial blower |
| EP2389352B1 (en) * | 2009-01-26 | 2019-05-08 | The Trustees Of The University Of Pennsylvania | Arginase inhibitors and methods of use |
| ES2729936T3 (en) | 2010-04-22 | 2019-11-07 | Mars Inc | Arginase inhibitors and their therapeutic applications |
| PL2632927T3 (en) | 2010-10-26 | 2016-09-30 | Boronates as arginase inhibitors | |
| US8894970B2 (en) | 2010-12-31 | 2014-11-25 | Corridor Pharmaceuticals, Inc. | Arginase inhibitors and methods of use thereof |
| MX343534B (en) | 2011-10-19 | 2016-11-09 | Mars Inc | Inhibitors of arginase and their therapeutic applications. |
| EP2768509B1 (en) | 2011-10-20 | 2017-03-22 | Glaxosmithkline LLC | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| IN2014DN09678A (en) | 2012-04-18 | 2015-07-31 | Mars Inc | |
| TWI660739B (en) | 2013-10-25 | 2019-06-01 | 製藥公司 | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy |
| CN105879030A (en) | 2014-09-30 | 2016-08-24 | 复旦大学 | Synergistic drug compound for treating tumor and preparation method thereof |
| WO2016153078A1 (en) | 2015-03-20 | 2016-09-29 | Opiyo Sammy Oyoo | Use of suramin and arginase inhibitors in malignant neoplasia |
| MX2017016868A (en) | 2015-06-23 | 2018-09-06 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity. |
| KR102434308B1 (en) | 2015-10-30 | 2022-08-19 | 칼리테라 바이오사이언시즈, 인코포레이티드 | Compositions and methods for inhibiting arginine activity |
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