KR101886643B1 - 라코사마이드의 제조방법 - Google Patents

라코사마이드의 제조방법 Download PDF

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Publication number
KR101886643B1
KR101886643B1 KR1020150157145A KR20150157145A KR101886643B1 KR 101886643 B1 KR101886643 B1 KR 101886643B1 KR 1020150157145 A KR1020150157145 A KR 1020150157145A KR 20150157145 A KR20150157145 A KR 20150157145A KR 101886643 B1 KR101886643 B1 KR 101886643B1
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formula
reaction
benzyl
serine
benzylamine
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Korean (ko)
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KR20170034281A (ko
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키란 디비 사트찬드라
아스와타 나라야나 라오 마이소레
나우슈딘 샤이크
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디비＇스 라보라토리스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020150157145A 2015-09-18 2015-11-10 라코사마이드의 제조방법 Active KR101886643B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN5001/CHE/2015 2015-09-18
IN5001CH2015 IN2015CH05001A (enExample) 2015-09-18 2015-09-18

Publications (2)

Publication Number Publication Date
KR20170034281A KR20170034281A (ko) 2017-03-28
KR101886643B1 true KR101886643B1 (ko) 2018-08-08

Family

ID=54398495

Family Applications (1)

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KR1020150157145A Active KR101886643B1 (ko) 2015-09-18 2015-11-10 라코사마이드의 제조방법

Country Status (12)

Country Link
US (1) US9447024B1 (enExample)
EP (1) EP3144295B1 (enExample)
KR (1) KR101886643B1 (enExample)
CN (1) CN106543018A (enExample)
DK (1) DK3144295T3 (enExample)
ES (1) ES2708176T3 (enExample)
HR (1) HRP20190403T1 (enExample)
HU (1) HUE043136T2 (enExample)
IN (1) IN2015CH05001A (enExample)
SI (1) SI3144295T1 (enExample)
TR (1) TR201901398T4 (enExample)
TW (1) TWI634100B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107641087A (zh) * 2017-06-01 2018-01-30 合肥远志医药科技开发有限公司 一种工业化拉科酰胺的制备方法
CN108558690B (zh) * 2018-03-28 2021-04-20 浙江海正药业股份有限公司 环丝氨酸酯化物盐酸盐的晶型及其制备方法
CN110320291A (zh) * 2019-06-21 2019-10-11 山东省药学科学院 一种hplc法定量检测拉考沙胺注射液含量的方法
CN115825300B (zh) * 2022-11-30 2024-12-06 山东百诺医药股份有限公司 一种检测拉考沙胺对映异构体的反相液相色谱方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099033A1 (en) * 2010-02-09 2011-08-18 Msn Laboratories Limited Process for preparing (r)-2-acetamido-n-benzyl-3-methoxy-propionamide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773475A (en) 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (en) 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US8093426B2 (en) 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
WO2011039781A1 (en) 2009-09-25 2011-04-07 Cadila Healthcare Limited Processes for the preparation of lacosamide and intermediates thereof
IT1398044B1 (it) 2010-01-29 2013-02-07 Archimica Srl Processo per la preparazione della lacosamide
WO2011095995A1 (en) * 2010-02-08 2011-08-11 Natco Pharma Limited A process for the preparation of lacosamide
US20130123537A1 (en) * 2010-05-17 2013-05-16 K a s s Narayan Garimella Process for the preparation of lacosamide
EP2399901A1 (en) * 2010-06-23 2011-12-28 Archimica GmbH Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide
ES2619403T3 (es) * 2010-10-19 2017-06-26 Euticals Gmbh Proceso para producir lacosamida
EP2487152A1 (en) 2010-11-17 2012-08-15 UCB Pharma GmbH Process for the preparation of Lacosamide including resolution of O-methyl-DL-serine
CN103113256A (zh) * 2011-11-17 2013-05-22 苏州洪瑞医药科技有限公司 一种拉科酰胺的合成方法
CN104892450A (zh) * 2015-06-01 2015-09-09 江苏海岸药业有限公司 一种拉科酰胺的制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099033A1 (en) * 2010-02-09 2011-08-18 Msn Laboratories Limited Process for preparing (r)-2-acetamido-n-benzyl-3-methoxy-propionamide

Also Published As

Publication number Publication date
DK3144295T3 (en) 2019-03-25
KR20170034281A (ko) 2017-03-28
HRP20190403T1 (hr) 2019-05-03
CN106543018A (zh) 2017-03-29
SI3144295T1 (sl) 2019-03-29
TR201901398T4 (tr) 2019-02-21
IN2015CH05001A (enExample) 2015-10-16
US9447024B1 (en) 2016-09-20
EP3144295A1 (en) 2017-03-22
EP3144295B1 (en) 2018-12-05
ES2708176T3 (es) 2019-04-09
TW201711992A (zh) 2017-04-01
TWI634100B (zh) 2018-09-01
HUE043136T2 (hu) 2019-07-29

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