IN2015CH05001A - - Google Patents

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Publication number
IN2015CH05001A
IN2015CH05001A IN5001CH2015A IN2015CH05001A IN 2015CH05001 A IN2015CH05001 A IN 2015CH05001A IN 5001CH2015 A IN5001CH2015 A IN 5001CH2015A IN 2015CH05001 A IN2015CH05001 A IN 2015CH05001A
Authority
IN
India
Prior art keywords
acetamido
benzyl
methoxypropionamide
lacosamide
benzylamine
Prior art date
Application number
Inventor
Kiran Divi Satchandra
Aswantha Narayana Rao Mysore
Nowshuddin Shaik
Original Assignee
Divis Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54398495&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2015CH05001(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Divis Lab Ltd filed Critical Divis Lab Ltd
Priority to IN5001CH2015 priority Critical patent/IN2015CH05001A/en
Priority to US14/885,321 priority patent/US9447024B1/en
Publication of IN2015CH05001A publication Critical patent/IN2015CH05001A/en
Priority to SI201530610T priority patent/SI3144295T1/en
Priority to ES15003058T priority patent/ES2708176T3/en
Priority to DK15003058.3T priority patent/DK3144295T3/en
Priority to EP15003058.3A priority patent/EP3144295B1/en
Priority to HUE15003058A priority patent/HUE043136T2/en
Priority to TR2019/01398T priority patent/TR201901398T4/en
Priority to KR1020150157145A priority patent/KR101886643B1/en
Priority to TW104143667A priority patent/TWI634100B/en
Priority to CN201511017774.6A priority patent/CN106543018A/en
Priority to HRP20190403TT priority patent/HRP20190403T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A novel process for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide (Lacosamide) is described. It comprises reacting N-acetyl-D-serine methyl ester with benzylamine catalyzed by a non-nucleophilic base to obtain (R)-2-acetamido-2-N-benzyl-3-hydroxy propionamide followed by its methylation.
IN5001CH2015 2015-09-18 2015-09-18 IN2015CH05001A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IN5001CH2015 IN2015CH05001A (en) 2015-09-18 2015-09-18
US14/885,321 US9447024B1 (en) 2015-09-18 2015-10-16 Process for the preparation of lacosamide
TR2019/01398T TR201901398T4 (en) 2015-09-18 2015-10-23 The process of preparing lacosamide.
HUE15003058A HUE043136T2 (en) 2015-09-18 2015-10-23 Process for the preparation of lacosamide
ES15003058T ES2708176T3 (en) 2015-09-18 2015-10-23 I proceed for the preparation of lacosamide
SI201530610T SI3144295T1 (en) 2015-09-18 2015-10-23 Process for the preparation of lacosamide
DK15003058.3T DK3144295T3 (en) 2015-09-18 2015-10-23 METHOD FOR LACOSAMIDE PREPARATION
EP15003058.3A EP3144295B1 (en) 2015-09-18 2015-10-23 Process for the preparation of lacosamide
KR1020150157145A KR101886643B1 (en) 2015-09-18 2015-11-10 Process for the Preparation of Lacosamide
TW104143667A TWI634100B (en) 2015-09-18 2015-12-25 Process for the preparation of lacosamide
CN201511017774.6A CN106543018A (en) 2015-09-18 2015-12-29 The method for preparing scheme for lacosamide
HRP20190403TT HRP20190403T1 (en) 2015-09-18 2019-03-01 Process for the preparation of lacosamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN5001CH2015 IN2015CH05001A (en) 2015-09-18 2015-09-18

Publications (1)

Publication Number Publication Date
IN2015CH05001A true IN2015CH05001A (en) 2015-10-16

Family

ID=54398495

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5001CH2015 IN2015CH05001A (en) 2015-09-18 2015-09-18

Country Status (12)

Country Link
US (1) US9447024B1 (en)
EP (1) EP3144295B1 (en)
KR (1) KR101886643B1 (en)
CN (1) CN106543018A (en)
DK (1) DK3144295T3 (en)
ES (1) ES2708176T3 (en)
HR (1) HRP20190403T1 (en)
HU (1) HUE043136T2 (en)
IN (1) IN2015CH05001A (en)
SI (1) SI3144295T1 (en)
TR (1) TR201901398T4 (en)
TW (1) TWI634100B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107641087A (en) * 2017-06-01 2018-01-30 合肥远志医药科技开发有限公司 A kind of preparation method for industrializing scheme for lacosamide
CN108558690B (en) * 2018-03-28 2021-04-20 浙江海正药业股份有限公司 Crystal form of cycloserine esterified substance hydrochloride and preparation method thereof
CN110320291A (en) * 2019-06-21 2019-10-11 山东省药学科学院 A kind of method of HPLC standard measure detection lacosamide injection liquid hold-up
CN115825300A (en) * 2022-11-30 2023-03-21 山东百诺医药股份有限公司 Reverse phase liquid chromatography method for detecting lacosamide enantiomer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773475A (en) 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (en) 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US8093426B2 (en) 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
US8853439B2 (en) 2009-09-25 2014-10-07 Cadila Healthcare Limited Processes for the preparation of lacosamide and intermediates thereof
IT1398044B1 (en) * 2010-01-29 2013-02-07 Archimica Srl PROCESS FOR THE PREPARATION OF LACOSAMIDE
EP2534128A1 (en) * 2010-02-08 2012-12-19 Natco Pharma Limited A process for the preparation of lacosamide
WO2011099033A1 (en) * 2010-02-09 2011-08-18 Msn Laboratories Limited Process for preparing (r)-2-acetamido-n-benzyl-3-methoxy-propionamide
US20130123537A1 (en) * 2010-05-17 2013-05-16 K a s s Narayan Garimella Process for the preparation of lacosamide
EP2399901A1 (en) * 2010-06-23 2011-12-28 Archimica GmbH Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide
HUE031138T2 (en) * 2010-10-19 2017-06-28 Euticals Gmbh Process for producing Lacosamide
EP2487152A1 (en) 2010-11-17 2012-08-15 UCB Pharma GmbH Process for the preparation of Lacosamide including resolution of O-methyl-DL-serine
CN103113256A (en) * 2011-11-17 2013-05-22 苏州洪瑞医药科技有限公司 Synthetizing method of lacosamide
CN104892450A (en) * 2015-06-01 2015-09-09 江苏海岸药业有限公司 Preparation method of lacosamide

Also Published As

Publication number Publication date
KR20170034281A (en) 2017-03-28
TR201901398T4 (en) 2019-02-21
CN106543018A (en) 2017-03-29
HRP20190403T1 (en) 2019-05-03
DK3144295T3 (en) 2019-03-25
SI3144295T1 (en) 2019-03-29
TW201711992A (en) 2017-04-01
HUE043136T2 (en) 2019-07-29
KR101886643B1 (en) 2018-08-08
EP3144295A1 (en) 2017-03-22
TWI634100B (en) 2018-09-01
EP3144295B1 (en) 2018-12-05
US9447024B1 (en) 2016-09-20
ES2708176T3 (en) 2019-04-09

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