KR101847501B1 - 아이소액티오사이드 또는 이의 약학적으로 허용가능한 염의 용도 - Google Patents

아이소액티오사이드 또는 이의 약학적으로 허용가능한 염의 용도 Download PDF

Info

Publication number
KR101847501B1
KR101847501B1 KR1020137000895A KR20137000895A KR101847501B1 KR 101847501 B1 KR101847501 B1 KR 101847501B1 KR 1020137000895 A KR1020137000895 A KR 1020137000895A KR 20137000895 A KR20137000895 A KR 20137000895A KR 101847501 B1 KR101847501 B1 KR 101847501B1
Authority
KR
South Korea
Prior art keywords
beta
disease
amyloid
thioside
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020137000895A
Other languages
English (en)
Korean (ko)
Other versions
KR20130095246A (ko
Inventor
항칭 린
무환 수
영밍 후앙
징징 탕
Original Assignee
신파 티엔리 파머슈티컬 컴퍼니 리미티드 (항저우)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 신파 티엔리 파머슈티컬 컴퍼니 리미티드 (항저우) filed Critical 신파 티엔리 파머슈티컬 컴퍼니 리미티드 (항저우)
Publication of KR20130095246A publication Critical patent/KR20130095246A/ko
Application granted granted Critical
Publication of KR101847501B1 publication Critical patent/KR101847501B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020137000895A 2010-06-16 2011-06-16 아이소액티오사이드 또는 이의 약학적으로 허용가능한 염의 용도 Active KR101847501B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35516910P 2010-06-16 2010-06-16
US61/355,169 2010-06-16
PCT/CN2011/000998 WO2011157059A1 (zh) 2010-06-16 2011-06-16 异类叶升麻苷或其药学上可接受的盐的用途

Publications (2)

Publication Number Publication Date
KR20130095246A KR20130095246A (ko) 2013-08-27
KR101847501B1 true KR101847501B1 (ko) 2018-05-24

Family

ID=44303534

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137000895A Active KR101847501B1 (ko) 2010-06-16 2011-06-16 아이소액티오사이드 또는 이의 약학적으로 허용가능한 염의 용도

Country Status (11)

Country Link
US (1) US20120009131A1 (enExample)
EP (1) EP2397144B1 (enExample)
JP (1) JP5968878B2 (enExample)
KR (1) KR101847501B1 (enExample)
CN (2) CN106176778A (enExample)
AU (1) AU2011267724B2 (enExample)
CA (1) CA2802441C (enExample)
MY (1) MY160878A (enExample)
SG (1) SG186717A1 (enExample)
TW (1) TWI486162B (enExample)
WO (1) WO2011157059A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044951A1 (en) * 2007-10-02 2009-04-08 Merz Pharma GmbH & Co. KGaA The use of substances for the treatment of loss of eyesight in humans with glaucoma and other degenerative eye diseases
MY171048A (en) * 2011-12-16 2019-09-23 Sinphar Tian Li Pharmaceutical Co Ltd Pharmaceutical composition for preventing or treating amyloid beta peptide-associated diseases or conditions
CN103622980A (zh) * 2013-12-12 2014-03-12 宁夏医科大学 肉苁蓉苯乙醇苷类化合物作为制备治疗骨质疏松症药物的应用及药物组合物
US20150291645A1 (en) * 2014-04-10 2015-10-15 Sinphar Pharmaceutical Co., Ltd. Isoacteoside derivative and use thereof
TWI650131B (zh) * 2014-07-03 2019-02-11 杏輝藥品工業股份有限公司 管花肉蓯蓉萃取物之用於製備保護眼部細胞之藥品或食品用途
CN108785320A (zh) * 2018-04-13 2018-11-13 浙江大学 异毛蕊花糖苷在制备激活Nrf2-ARE信号通路的保健品/药品中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100500584B1 (ko) * 2002-08-12 2005-07-12 경희대학교 산학협력단 신경성장인자와 유사 작용을 갖는 육종용 추출물 및 이를함유하는 조성물
KR100514076B1 (ko) * 2003-01-10 2005-09-13 주식회사 엘컴사이언스 페닐에타노이드 유도체를 포함하는 퇴행성 뇌신경계질환의 예방 및 치료용 조성물
TW200416036A (en) * 2003-02-18 2004-09-01 Sinphar Pharmaceutical Co Ltd Medicinal preparation containing phenylethanoid glycosides extracted from herbaceous plant, cistanche tubulosa (schenk.) wight, process of making the same, and uses of the same
CN1268341C (zh) * 2003-03-04 2006-08-09 杏辉天力（杭州）药业有限公司 来源于管花肉苁蓉的含有苯乙醇苷的制剂及其制备方法和用途
JP2006312594A (ja) * 2005-05-06 2006-11-16 Univ Nihon 学習・記憶障害予防用組成物
EP1736167B1 (en) * 2005-06-20 2018-03-21 I.R.B. Istituto Di Ricerche Biotecnologiche S.r.l. Extracts obtained from cell line cultures from Syringa vulgaris IRB-SV25/B (DMS:16857), their preparation and use
JP4936507B2 (ja) * 2006-01-18 2012-05-23 学校法人近畿大学 カンカニクジュヨウの抽出物より得られる強壮剤又は強精剤、配糖体化合物及びそれらの用途
CN100446792C (zh) * 2006-03-21 2008-12-31 中国海洋大学 一种改善记忆的中药
GB0608386D0 (en) * 2006-04-27 2006-06-07 Senexis Ltd Compounds
JP5410683B2 (ja) * 2008-02-19 2014-02-05 学校法人近畿大学 カンカニクジュヨウから得られる肝保護剤及び抗ＴＮＦ−α作用剤
JP2009196908A (ja) * 2008-02-20 2009-09-03 Yomeishu Seizo Co Ltd リパーゼ阻害剤及び飲食品
JP2009209063A (ja) * 2008-03-03 2009-09-17 Univ Kinki 皮膚外用剤または皮膚化粧料
CN101264094B (zh) * 2008-04-16 2013-11-13 西藏自治区高原生物研究所 藏波罗花苯丙素苷组合物及其制备方法和用途
JP2009263279A (ja) * 2008-04-25 2009-11-12 Oriza Yuka Kk エラスターゼ阻害剤
CN101703125B (zh) * 2009-12-04 2012-07-04 中国科学院新疆生态与地理研究所 肉苁蓉红茶及其制备方法

Also Published As

Publication number Publication date
CN106176778A (zh) 2016-12-07
JP2013528627A (ja) 2013-07-11
MY160878A (en) 2017-03-31
AU2011267724B2 (en) 2016-07-28
TW201200137A (en) 2012-01-01
KR20130095246A (ko) 2013-08-27
EP2397144A1 (en) 2011-12-21
JP5968878B2 (ja) 2016-08-10
CA2802441A1 (en) 2011-12-22
AU2011267724A1 (en) 2013-01-24
WO2011157059A1 (zh) 2011-12-22
US20120009131A1 (en) 2012-01-12
CN103037868A (zh) 2013-04-10
CA2802441C (en) 2018-08-07
TWI486162B (zh) 2015-06-01
SG186717A1 (en) 2013-02-28
EP2397144B1 (en) 2014-12-31

Similar Documents

Publication Publication Date Title
KR102317160B1 (ko) 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식 향상 또는 장수 증가
KR101847501B1 (ko) 아이소액티오사이드 또는 이의 약학적으로 허용가능한 염의 용도
KR20020035855A (ko) 약용인삼을 포함하는 뇌세포 또는 신경세포 보호제
US20160317419A1 (en) Method of improving skin health and compositions therefor
CN116546960A (zh) 衰老细胞裂解化合物和组合物
WO2021164210A1 (zh) 没食子酸衍生物防治动脉粥样硬化疾病的应用
KR101807953B1 (ko) 고수 추출물을 유효성분으로 하는 치매 예방 또는 치료용 약학적 조성물
US20200093929A1 (en) Pharmaceutical composition for the prevention and treatment of memory and cognitive deficits related to ageing
Wang et al. Neuroprotection of Strongylocentrotus nudus gangliosides against Alzheimer’s disease via regulation of neurite loss and mitochondrial apoptosis
KR102496282B1 (ko) 사이토칼라신 d 또는 sag를 포함하는 항노화용 조성물 및 항노화 물질 스크리닝 방법
Lee et al. The effects of Korean Red Ginseng-derived components on oligodendrocyte lineage cells: Distinct facilitatory roles of the non-saponin and saponin fractions, and Rb1, in proliferation, differentiation and myelination
JP2001139483A (ja) 薬用人蔘からなる脳細胞または神経細胞保護剤
JP2017071600A (ja) くすぶり炎症抑制剤
KR100535266B1 (ko) 항노화 활성이 우수한 현삼 추출물 및 이를 포함하는 조성물
JP2024505458A (ja) コリンエステラーゼ阻害剤および抗酸化剤を含む脳疾患を治療するための医薬組成物
KR100597612B1 (ko) 항노화 활성이 우수한 현삼 추출물을 포함하는 식품 조성물
Yamamura et al. Aging-Associated Mitochondrial Decline Accelerates Skin Aging and Obesity
US20240066017A1 (en) Prevention or treatment of brain disease and adverse effects of cholinesterase inhibitors
US20250367099A1 (en) Urolithin combinations
US20170189376A1 (en) Butyroyloxymethyl diethyl phosphate compounds and uses thereof
US20090131339A1 (en) Compounds having neuroprotective properties
KR102089376B1 (ko) 디아민 유도체를 포함하는 뇌졸중, 신경 세포 손상, 파킨슨병 또는 루게릭병의 예방 또는 치료용 조성물
KR20200126354A (ko) 진세노사이드 Rb2를 포함하는 신경세포 보호용 조성물
KR20130131797A (ko) 당세라마이드 유도체를 포함하는 기억력 개선, 인지능력 개선, 치매 예방 또는 치료 효과를 나타내는 약학적 조성물
KR20170066092A (ko) 올레산 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 근육손실 예방 및 치료용 약학적 조성물

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20130114

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20160609

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20170329

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20180307

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20180404

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20180405

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20210318

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20220324

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20240329

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20250401

Start annual number: 8

End annual number: 8