CN103037868A - 异类叶升麻苷或其药学上可接受的盐的用途 - Google Patents
异类叶升麻苷或其药学上可接受的盐的用途 Download PDFInfo
- Publication number
- CN103037868A CN103037868A CN2011800298829A CN201180029882A CN103037868A CN 103037868 A CN103037868 A CN 103037868A CN 2011800298829 A CN2011800298829 A CN 2011800298829A CN 201180029882 A CN201180029882 A CN 201180029882A CN 103037868 A CN103037868 A CN 103037868A
- Authority
- CN
- China
- Prior art keywords
- isoacteoside
- pharmaceutically acceptable
- acceptable salt
- amyloid beta
- aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FNMHEHXNBNCPCI-QEOJJFGVSA-N Isoacteoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O[C@H](COC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@H]1O FNMHEHXNBNCPCI-QEOJJFGVSA-N 0.000 title abstract description 3
- FNMHEHXNBNCPCI-RYEKTNFUSA-N isoacteoside Natural products C[C@@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](COC(=O)C=Cc3ccc(O)c(O)c3)O[C@@H](OCCc4ccc(O)c(O)c4)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O FNMHEHXNBNCPCI-RYEKTNFUSA-N 0.000 title abstract description 3
- 150000003839 salts Chemical class 0.000 title abstract description 3
- QFRYQWYZSQDFOS-UHFFFAOYSA-N verbascoside Natural products CC1OC(COC2C(O)C(COC3OC(C(O)C(O)C3O)C(=O)O)OC(Oc4cc(O)cc5OC(=CC(=O)c45)c6ccc(O)c(O)c6)C2O)C(O)C(O)C1O QFRYQWYZSQDFOS-UHFFFAOYSA-N 0.000 title abstract description 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 2
- 230000035508 accumulation Effects 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000005755 formation reaction Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
异类叶升麻苷或其医药学上可接受的盐被作为一种淀粉样β肽生成、累积或聚集的抑制剂,以预防或治疗与淀粉样β肽相关性疾病或状况。
Description
PCT国内申请,说明书已公开。
Claims (1)
- PCT国内申请,权利要求书已公开。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610646844.2A CN106176778A (zh) | 2010-06-16 | 2011-06-16 | 异类叶升麻苷或其药学上可接受的盐的用途 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35516910P | 2010-06-16 | 2010-06-16 | |
US61/355,169 | 2010-06-16 | ||
PCT/CN2011/000998 WO2011157059A1 (zh) | 2010-06-16 | 2011-06-16 | 异类叶升麻苷或其药学上可接受的盐的用途 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610646844.2A Division CN106176778A (zh) | 2010-06-16 | 2011-06-16 | 异类叶升麻苷或其药学上可接受的盐的用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103037868A true CN103037868A (zh) | 2013-04-10 |
Family
ID=44303534
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011800298829A Pending CN103037868A (zh) | 2010-06-16 | 2011-06-16 | 异类叶升麻苷或其药学上可接受的盐的用途 |
CN201610646844.2A Pending CN106176778A (zh) | 2010-06-16 | 2011-06-16 | 异类叶升麻苷或其药学上可接受的盐的用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610646844.2A Pending CN106176778A (zh) | 2010-06-16 | 2011-06-16 | 异类叶升麻苷或其药学上可接受的盐的用途 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20120009131A1 (zh) |
EP (1) | EP2397144B1 (zh) |
JP (1) | JP5968878B2 (zh) |
KR (1) | KR101847501B1 (zh) |
CN (2) | CN103037868A (zh) |
AU (1) | AU2011267724B2 (zh) |
CA (1) | CA2802441C (zh) |
MY (1) | MY160878A (zh) |
SG (1) | SG186717A1 (zh) |
TW (1) | TWI486162B (zh) |
WO (1) | WO2011157059A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2044951A1 (en) * | 2007-10-02 | 2009-04-08 | Merz Pharma GmbH & Co. KGaA | The use of substances for the treatment of loss of eyesight in humans with glaucoma and other degenerative eye diseases |
KR102048289B1 (ko) * | 2011-12-16 | 2020-01-08 | 신파 티엔리 파머슈티컬 컴퍼니 리미티드 (항저우) | 아밀로이드 β 펩타이드 관련 질환 또는 이상을 예방 또는 치료하기 위한 약학적 조성물 |
CN103622980A (zh) * | 2013-12-12 | 2014-03-12 | 宁夏医科大学 | 肉苁蓉苯乙醇苷类化合物作为制备治疗骨质疏松症药物的应用及药物组合物 |
TWI619721B (zh) * | 2014-04-10 | 2018-04-01 | 杏輝藥品工業股份有限公司 | 異類葉升麻苷衍生物及其製造方法與用途 |
TWI650131B (zh) * | 2014-07-03 | 2019-02-11 | 杏輝藥品工業股份有限公司 | 管花肉蓯蓉萃取物之用於製備保護眼部細胞之藥品或食品用途 |
CN108785320A (zh) * | 2018-04-13 | 2018-11-13 | 浙江大学 | 异毛蕊花糖苷在制备激活Nrf2-ARE信号通路的保健品/药品中的应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040064830A (ko) * | 2003-01-10 | 2004-07-21 | 주식회사 엘컴사이언스 | 페닐에타노이드 유도체를 포함하는 퇴행성 뇌신경계질환의 예방 및 치료용 조성물 |
EP1736167A2 (en) * | 2005-06-20 | 2006-12-27 | I.R.B. Istituto Di Ricerche Biotecnologiche S.r.l. | Extracts obtained from cell line cultures from plants belonging to the Oleaceae family (e.g. Syringa vulgaris), their preparation and use |
WO2007125351A1 (en) * | 2006-04-27 | 2007-11-08 | Senexis Limited | Pyrimidine derivatives for the treatment of amyloid-related diseases |
CN101264094A (zh) * | 2008-04-16 | 2008-09-17 | 西藏自治区高原生物研究所 | 藏波罗花苯丙素苷组合物及其制备方法和用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100500584B1 (ko) * | 2002-08-12 | 2005-07-12 | 경희대학교 산학협력단 | 신경성장인자와 유사 작용을 갖는 육종용 추출물 및 이를함유하는 조성물 |
TW200416036A (en) * | 2003-02-18 | 2004-09-01 | Sinphar Pharmaceutical Co Ltd | Medicinal preparation containing phenylethanoid glycosides extracted from herbaceous plant, cistanche tubulosa (schenk.) wight, process of making the same, and uses of the same |
CN1268341C (zh) * | 2003-03-04 | 2006-08-09 | 杏辉天力(杭州)药业有限公司 | 来源于管花肉苁蓉的含有苯乙醇苷的制剂及其制备方法和用途 |
JP2006312594A (ja) * | 2005-05-06 | 2006-11-16 | Univ Nihon | 学習・記憶障害予防用組成物 |
JP4936507B2 (ja) * | 2006-01-18 | 2012-05-23 | 学校法人近畿大学 | カンカニクジュヨウの抽出物より得られる強壮剤又は強精剤、配糖体化合物及びそれらの用途 |
CN100446792C (zh) * | 2006-03-21 | 2008-12-31 | 中国海洋大学 | 一种改善记忆的中药 |
JP5410683B2 (ja) * | 2008-02-19 | 2014-02-05 | 学校法人近畿大学 | カンカニクジュヨウから得られる肝保護剤及び抗TNF−α作用剤 |
JP2009196908A (ja) * | 2008-02-20 | 2009-09-03 | Yomeishu Seizo Co Ltd | リパーゼ阻害剤及び飲食品 |
JP2009209063A (ja) * | 2008-03-03 | 2009-09-17 | Univ Kinki | 皮膚外用剤または皮膚化粧料 |
JP2009263279A (ja) * | 2008-04-25 | 2009-11-12 | Oriza Yuka Kk | エラスターゼ阻害剤 |
CN101703125B (zh) * | 2009-12-04 | 2012-07-04 | 中国科学院新疆生态与地理研究所 | 肉苁蓉红茶及其制备方法 |
-
2011
- 2011-06-10 TW TW100120452A patent/TWI486162B/zh active
- 2011-06-15 US US13/160,663 patent/US20120009131A1/en not_active Abandoned
- 2011-06-16 EP EP11170127.2A patent/EP2397144B1/en active Active
- 2011-06-16 CN CN2011800298829A patent/CN103037868A/zh active Pending
- 2011-06-16 JP JP2013514533A patent/JP5968878B2/ja active Active
- 2011-06-16 AU AU2011267724A patent/AU2011267724B2/en active Active
- 2011-06-16 SG SG2012091914A patent/SG186717A1/en unknown
- 2011-06-16 CA CA2802441A patent/CA2802441C/en active Active
- 2011-06-16 KR KR1020137000895A patent/KR101847501B1/ko active IP Right Grant
- 2011-06-16 WO PCT/CN2011/000998 patent/WO2011157059A1/zh active Application Filing
- 2011-06-16 MY MYPI2012005431A patent/MY160878A/en unknown
- 2011-06-16 CN CN201610646844.2A patent/CN106176778A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040064830A (ko) * | 2003-01-10 | 2004-07-21 | 주식회사 엘컴사이언스 | 페닐에타노이드 유도체를 포함하는 퇴행성 뇌신경계질환의 예방 및 치료용 조성물 |
EP1736167A2 (en) * | 2005-06-20 | 2006-12-27 | I.R.B. Istituto Di Ricerche Biotecnologiche S.r.l. | Extracts obtained from cell line cultures from plants belonging to the Oleaceae family (e.g. Syringa vulgaris), their preparation and use |
WO2007125351A1 (en) * | 2006-04-27 | 2007-11-08 | Senexis Limited | Pyrimidine derivatives for the treatment of amyloid-related diseases |
CN101448794A (zh) * | 2006-04-27 | 2009-06-03 | 塞内希斯有限公司 | 用于治疗淀粉样蛋白相关性疾病的嘧啶衍生物 |
CN101264094A (zh) * | 2008-04-16 | 2008-09-17 | 西藏自治区高原生物研究所 | 藏波罗花苯丙素苷组合物及其制备方法和用途 |
Also Published As
Publication number | Publication date |
---|---|
WO2011157059A1 (zh) | 2011-12-22 |
KR101847501B1 (ko) | 2018-05-24 |
US20120009131A1 (en) | 2012-01-12 |
CA2802441A1 (en) | 2011-12-22 |
KR20130095246A (ko) | 2013-08-27 |
EP2397144B1 (en) | 2014-12-31 |
TWI486162B (zh) | 2015-06-01 |
CA2802441C (en) | 2018-08-07 |
CN106176778A (zh) | 2016-12-07 |
TW201200137A (en) | 2012-01-01 |
JP5968878B2 (ja) | 2016-08-10 |
EP2397144A1 (en) | 2011-12-21 |
MY160878A (en) | 2017-03-31 |
AU2011267724A1 (en) | 2013-01-24 |
AU2011267724B2 (en) | 2016-07-28 |
SG186717A1 (en) | 2013-02-28 |
JP2013528627A (ja) | 2013-07-11 |
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Application publication date: 20130410 |