JP2017071600A - くすぶり炎症抑制剤 - Google Patents
くすぶり炎症抑制剤 Download PDFInfo
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- JP2017071600A JP2017071600A JP2016197736A JP2016197736A JP2017071600A JP 2017071600 A JP2017071600 A JP 2017071600A JP 2016197736 A JP2016197736 A JP 2016197736A JP 2016197736 A JP2016197736 A JP 2016197736A JP 2017071600 A JP2017071600 A JP 2017071600A
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- extract
- ethanolamine
- liver
- aging
- smoldering
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Abstract
Description
に、異常が見つかる頻度が激増してきた。
皮膚を健全化して健康な皮膚を取り戻す方法及び/又は身体機能の低下を防止する方法を提供する。
ン、カゼイン加水分解物やラクトフェリンなど)、「ミネラル類」(カルシウム、イオウ、マグネシウム、亜鉛、セレンや鉄など)、「キノコ類」(シイタケエキス、ヤマブシタケなど)、「種子・胚芽・果実類」(ザクロ、アセロラ、プルーン、ブルーベリーやゴマなど)、「健康茶エキス」(ハブ茶、甜茶やドクダミ茶など)、そしてハチミツ、グルコサミン、米由来セラミドやヒアルロン酸、N−アセチルグルコサミン、ビルベリー、大豆イソフラボン、ヘスペリジン等を組み合わせることができる。
〔試験例1〕
ブタの正常分娩胎盤を用い、洗浄後にホモジネートした原料を用いて殺菌処理後に、水を加えて攪拌しながら1.0重量%の蛋白分解酵素を加えて一昼夜保温して消化し、遠心分離して酵素消化液を採取した。酵素消化液を濃縮し、噴霧乾燥することによりブタ胎盤
抽出物を得た。得られたブタ胎盤抽出物は、1g中にエタノールアミン400μg、グリシン75mg、セリン25mg、スレオニン25mgを含有することを確認した。
エンドトキシンに起因する肝障害は、微量に血中に浸入する腸内細菌由来の成分を原因とする。通常、敗血症などの深刻な感染症による大量のエンドトキシンへの暴露を除いて、血中にわずかに混入したエンドトキシンが慢性炎症へ移行することはまれである。一方で、糖尿病や長期にわたるアルコール摂取、高度な疲労や化学物質への暴露は、腸の透過性を昂進させることで腸内菌に由来するエンドトキシンを血中に移行させ、またこれらの習慣や疾病では、肝クッパー細胞(在住マクロファージ系統)などでエンドトキシン刺激への過敏性が誘導されているため、肝臓で強い炎症が引き起こされ、肝障害を誘導することが知られている。
試験例1のブタ胎盤抽出物をRPMI1640 (Sigma) + 5% FBS (Invitrogen) を含む培地に終濃度0.5-30 mg/mlで添加し、2時間前処理後、LPS-05(Sigma)を終濃度30 ng/mlで細胞に添加し、5時間インキュベートした。
細胞をPBS(-)で洗浄後に、RNeasy Mini キット (Qiagen)のキットに製品添付のプロトコールに従いTotal RNAの抽出を実施した。Total RNAは、ReverTra Ace qPCR RT Master Mix with gDNA Remover キット(TOYOBO)を使って、製品添付のプロトコールに従いcDNA合成に供した。
cDNAは、Fast SYBR Green Master Mix (Life technologies) を使い、製品プロトコール記載の条件に従い、StepOne Plus(Life technologies)を使用して、Realtime PCR分析によって遺伝子の定量を実施した。
プライマーは、以下のものを使用した。
IL-1beta (Primer Set ID: HA237369、 タカラバイオ)、 IL-6 (HA209655)、 TNFalpha (HA198263)、 iNOS (HA032546)。
肝線維化症は,臓器にコラーゲンを主体とする細胞外マトリクスが過剰蓄積することで発症する疾病であり、ほぼ全ての原因による肝細胞損傷に対して生ずる反応である。特に、肝炎ウイルスやエンドトキシン、アルコール、脂肪肝などで肝細胞が刺激されると、末梢血や骨髄から炎症細胞が損傷局所に集積し、線維化を促進するTGFbなどを放出して肝星細胞が活性化して、コラーゲン等の細胞外マトリクスの過剰蓄積を引き起こし、臓器の線維化が進行する事が知られる。
肝臓は、体内で最も容積を占める臓器であり、その機能は多岐にわたる。特に食物や、治療用の薬物、体内で生成される老廃物の解毒排出機能は重要であり、一旦、肝機能が低下すると体内の様々な臓器や皮膚などに変調が生じることが知られている。以下の試験例では、種々の薬物モデルを使用し、肝障害に対する胎盤抽出物及びエタノールアミンの影響を評価した。
ethamolph(Molecular device)にて、細胞質が失われている変性した肝細胞および肝炎症の指標の一つであるマクロファージ/クッパー細胞のマーカー(F4/80)の集積率を評価した。
飲酒モデルとして、エタノール強制投与による急性アルコール中毒モデルを作製し、胎盤抽出物およびエタノールアミンの肝臓でのアルコール代謝速度および、酩酊感・嘔吐感に由来する行動阻害に与える影響を評価した。
ど差は認められなかった。一方で、代謝物で悪酔いの原因であるアセトアルデヒドの濃度を測定したところ、胎盤抽出物投与群でのみ32%の有意な減少が認められた。
慢性アルコール性肝障害モデルとして、アルコール長期投与モデルを作製し、胎盤抽出物およびエタノールアミンの肝臓機能障害に与える影響を評価した。
出物のような幾つかの補助成分を含んだ形でのエタノールアミンの提供が望ましいと考えられる。
(成分)
(1)試験例1のブタ胎盤抽出物 90 g
(2)クエン酸三ナトリウム 10 g
(3)スクラロース 0.6 g
(4)クエン酸 10 g
(5)香料 6 g
(6)水 残 余
(合 計 3000 g)
水2000gに上記の(1)〜(5)を順次加えて溶解し、水を加えて3000gとする。次に、上記混合物を95℃まで加熱した後、容器に10gずつ充填し、ドリンクタイプの実施例1の液剤を得る。
(成分)
(1)試験例1の胎盤抽出物 300mg
(2)グリシン 10mg
(3)ニコチン酸アミド 5mg
(4)L−リジン塩酸塩 5mg
(5)L−アルギニン 5mg
(6)L−ヒスチジン 5mg
(7)ステアリン酸カルシウム 4mg
(8)ビタミンB1 2mg
(9)ビタミンB6 2mg
(10)ビタミンB2 2mg
(11)葉酸 0.2mg
(12)ビタミンD3 1mg
(13)ビタミンB12 0.5mg
(14)結晶セルロース 38.3mg
(合 計 380mg)
上記の(1)から(14)までの各成分の10000倍量を秤量・混合し、プルランカプセル1号に380mgずつ充填し、実施例3のカプセル剤を得る。
(処方)
(1)実施例1のブタ胎盤抽出物 25重量部
(2)乳糖 69重量部
(3)合成ケイ酸アルミニウム 5重量部
(4)ステアリン酸マグネシウム 1重量部
上記の各成分を混合し、その混合物を打錠機で1錠300mgに打錠して1錠中にブタ胎盤抽出物75mg含む錠剤を得る。
Claims (5)
- エタノールアミンとアミノ酸を有効成分とすることを特徴とする加齢に伴うくすぶり炎症抑制剤。
- 哺乳動物の胎盤抽出物、哺乳動物の母乳又は哺乳動物の肝臓抽出物に含有されるエタノールアミンとアミノ酸を有効成分とする加齢に伴うくすぶり炎症抑制剤。
- アミノ酸が、グリシン、セリン又はスレオニンの1種又は2種以上を含有する請求項1又は2に記載の加齢に伴うくすぶり炎症抑制剤。
- 加齢に伴うくすぶり炎症抑制が必要な対象に対し、エタノールアミンと、グリシン、セリン又はスレオニンの1種又は2種以上を摂取させることを特徴とする皮膚を健全化して健康な皮膚を取り戻す方法及び/又は身体機能の低下を防止する方法(但し、ヒトに対する医療行為を除く)。
- 加齢に伴うくすぶり炎症抑制剤の有効成分として、哺乳動物の胎盤抽出物、哺乳動物の母乳又は哺乳動物の肝臓抽出物に含有されるエタノールアミンとグリシン、セリン又はスレオニンの1種又は2種以上の使用。
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JP2021029154A (ja) * | 2019-08-21 | 2021-03-01 | アサヒグループ食品株式会社 | 栄養補助組成物及びその製造方法、動物抽出物又は栄養補助組成物の不快臭の抑制方法、並びに動物抽出物又は栄養補助組成物の不快臭抑制用組成物 |
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JP7042699B2 (ja) | 2018-06-13 | 2022-03-28 | 株式会社ミルボン | 評価方法、毛髪処理剤の選定方法、及び評価支援ツール |
JP2021029154A (ja) * | 2019-08-21 | 2021-03-01 | アサヒグループ食品株式会社 | 栄養補助組成物及びその製造方法、動物抽出物又は栄養補助組成物の不快臭の抑制方法、並びに動物抽出物又は栄養補助組成物の不快臭抑制用組成物 |
JP7353101B2 (ja) | 2019-08-21 | 2023-09-29 | アサヒグループ食品株式会社 | 栄養補助組成物及びその製造方法、動物抽出物又は栄養補助組成物の不快臭の抑制方法、並びに動物抽出物又は栄養補助組成物の不快臭抑制用組成物 |
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