JP7248840B2 - くすぶり炎症抑制剤 - Google Patents
くすぶり炎症抑制剤 Download PDFInfo
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- JP7248840B2 JP7248840B2 JP2022044766A JP2022044766A JP7248840B2 JP 7248840 B2 JP7248840 B2 JP 7248840B2 JP 2022044766 A JP2022044766 A JP 2022044766A JP 2022044766 A JP2022044766 A JP 2022044766A JP 7248840 B2 JP7248840 B2 JP 7248840B2
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Description
〔試験例1〕
ブタの正常分娩胎盤を用い、洗浄後にホモジネートした原料を用いて殺菌処理後に、水を加えて攪拌しながら1.0重量%の蛋白分解酵素を加えて一昼夜保温して消化し、遠心分離して酵素消化液を採取した。酵素消化液を濃縮し、噴霧乾燥することによりブタ胎盤抽出物を得た。得られたブタ胎盤抽出物は、1g中にエタノールアミン400μg、グリシン75mg、セリン25mg、スレオニン25mgを含有することを確認した。
エンドトキシンに起因する肝障害は、微量に血中に浸入する腸内細菌由来の成分を原因とする。通常、敗血症などの深刻な感染症による大量のエンドトキシンへの暴露を除いて、血中にわずかに混入したエンドトキシンが慢性炎症へ移行することはまれである。一方で、糖尿病や長期にわたるアルコール摂取、高度な疲労や化学物質への暴露は、腸の透過性を昂進させることで腸内菌に由来するエンドトキシンを血中に移行させ、またこれらの習慣や疾病では、肝クッパー細胞(在住マクロファージ系統)などでエンドトキシン刺激への過敏性が誘導されているため、肝臓で強い炎症が引き起こされ、肝障害を誘導することが知られている。
試験例1のブタ胎盤抽出物をRPMI1640 (Sigma) + 5% FBS (Invitrogen) を含む培地に終濃度0.5-30 mg/mlで添加し、2時間前処理後、LPS-05(Sigma)を終濃度30 ng/mlで細胞に添加し、5時間インキュベートした。
細胞をPBS(-)で洗浄後に、RNeasy Mini キット (Qiagen)のキットに製品添付のプロトコールに従いTotal RNAの抽出を実施した。Total RNAは、ReverTra Ace qPCR RT Master Mix with gDNA Remover キット(TOYOBO)を使って、製品添付のプロトコールに従いcDNA合成に供した。
cDNAは、Fast SYBR Green Master Mix (Life technologies) を使い、製品プロトコール記載の条件に従い、StepOne Plus(Life technologies)を使用して、Realtime PCR分析によって遺伝子の定量を実施した。
プライマーは、以下のものを使用した。
IL-1beta (Primer Set ID: HA237369、 タカラバイオ)、 IL-6 (HA209655)、 TNFalpha (HA198263)、 iNOS (HA032546)。
肝線維化症は,臓器にコラーゲンを主体とする細胞外マトリクスが過剰蓄積することで発症する疾病であり、ほぼ全ての原因による肝細胞損傷に対して生ずる反応である。特に、肝炎ウイルスやエンドトキシン、アルコール、脂肪肝などで肝細胞が刺激されると、末梢血や骨髄から炎症細胞が損傷局所に集積し、線維化を促進するTGFβなどを放出して肝星細胞が活性化して、コラーゲン等の細胞外マトリクスの過剰蓄積を引き起こし、臓器の線維化が進行する事が知られる。
肝臓は、体内で最も容積を占める臓器であり、その機能は多岐にわたる。特に食物や、治療用の薬物、体内で生成される老廃物の解毒排出機能は重要であり、一旦、肝機能が低下すると体内の様々な臓器や皮膚などに変調が生じることが知られている。以下の試験例では、種々の薬物モデルを使用し、肝障害に対する胎盤抽出物及びエタノールアミンの影響を評価した。
飲酒モデルとして、エタノール強制投与による急性アルコール中毒モデルを作製し、胎盤抽出物およびエタノールアミンの肝臓でのアルコール代謝速度および、酩酊感・嘔吐感に由来する行動阻害に与える影響を評価した。
慢性アルコール性肝障害モデルとして、アルコール長期投与モデルを作製し、胎盤抽出物およびエタノールアミンの肝臓機能障害に与える影響を評価した。
(成分)
(1)試験例1のブタ胎盤抽出物 90 g
(2)クエン酸三ナトリウム 10 g
(3)スクラロース 0.6 g
(4)クエン酸 10 g
(5)香料 6 g
(6)水 残 余
(合 計 3000 g)
水2000gに上記の(1)~(5)を順次加えて溶解し、水を加えて3000gとする。次に、上記混合物を95℃まで加熱した後、容器に10gずつ充填し、ドリンクタイプの実施例1の液剤を得る。
(成分)
(1)試験例1の胎盤抽出物 300mg
(2)グリシン 10mg
(3)ニコチン酸アミド 5mg
(4)L-リジン塩酸塩 5mg
(5)L-アルギニン 5mg
(6)L-ヒスチジン 5mg
(7)ステアリン酸カルシウム 4mg
(8)ビタミンB1 2mg
(9)ビタミンB6 2mg
(10)ビタミンB2 2mg
(11)葉酸 0.2mg
(12)ビタミンD3 1mg
(13)ビタミンB12 0.5mg
(14)結晶セルロース 38.3mg
(合 計 380mg)
上記の(1)から(14)までの各成分の10000倍量を秤量・混合し、プルランカプセル1号に380mgずつ充填し、実施例3のカプセル剤を得る。
(処方)
(1)実施例1のブタ胎盤抽出物 25重量部
(2)乳糖 69重量部
(3)合成ケイ酸アルミニウム 5重量部
(4)ステアリン酸マグネシウム 1重量部
上記の各成分を混合し、その混合物を打錠機で1錠300mgに打錠して1錠中にブタ胎盤抽出物75mg含む錠剤を得る。
Claims (3)
- 哺乳動物の胎盤抽出物を有効成分とする急性アルコール中毒予防剤。
- 哺乳動物の胎盤抽出物を有効成分とする急性アルコール中毒予防用のサプリメント。
- 哺乳動物の胎盤抽出物を有効成分とする急性アルコール中毒予防用の食品組成物。
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JP2020098215A Pending JP2020128438A (ja) | 2015-10-07 | 2020-06-05 | くすぶり炎症抑制剤 |
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Title |
---|
Kawakatsu, Miho ET AL.,"Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury throu,Journal of Radiation Research,2013年,Vol.54, No.2,pp.268-276 |
日本薬学会 第132年会 プログラム,2012年,30P1-am134欄 |
日薬理誌,1998年,111,117-125 |
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