JP5688233B2 - Tarc産生抑制剤 - Google Patents
Tarc産生抑制剤 Download PDFInfo
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- JP5688233B2 JP5688233B2 JP2010099391A JP2010099391A JP5688233B2 JP 5688233 B2 JP5688233 B2 JP 5688233B2 JP 2010099391 A JP2010099391 A JP 2010099391A JP 2010099391 A JP2010099391 A JP 2010099391A JP 5688233 B2 JP5688233 B2 JP 5688233B2
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- tarc
- tarc production
- production inhibitor
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Description
(成分)エピカテキンガレート、エピガロカテキン、エピガロカテキンガレート、エピガロカテキン−3−O−(3−O−メチル)ガレート、リコカルコンA、ペドゥンクラジン、ルゴシンC、カスアリクチン、イソストリクチニン、ストリクチニン、ルテオリン、レスベラトロール、リポテイコ酸及び/又はその塩、クルクミン、オイゲノール、ナリンギン、6−ショウガオール、L−カルニチン、L−アスコルビン酸及び/又はその誘導体、アスタキサンチン、β−カロテン、オキシ脂肪酸
(1)次に示す成分の1種又は2種以上から選択されることを特徴とする、TARC産生抑制剤。
(成分)エピカテキンガレート、エピガロカテキン、エピガロカテキンガレート、エピガロカテキン−3−O−(3−O−メチル)ガレート、リコカルコンA、ペドゥンクラジン、ルゴシンC、カスアリクチン、イソストリクチニン、ストリクチニン、ルテオリン、レスベラトロール、リポテイコ酸及び/又はその塩、クルクミン、オイゲノール、ナリンギン、6−ショウガオール、L−カルニチン、L−アスコルビン酸及び/又はその誘導体、アスタキサンチン、β−カロテン、オキシ脂肪酸
(2)(1)に記載のオキシ脂肪酸が、9−ヒドロキシ−10(E),12(Z)−オクタデカジエン酸、13−ヒドロキシ−9(E),11(E)−オクタデカジエン酸、9−ヒドロキシ−10(E),12(E)−オクタデカジエン酸の1種又は2種以上から選択されることを特徴とする、(1)に記載のTARC産生抑制剤。
(3)(1)又は(2)何れかに記載のTARC産生抑制剤を含有することを特徴とする、経口投与組成物。
(4)食品であることを特徴とする、(3)に記載の経口投与組成物。
(5)アレルギー性疾患を有さない、健常者に対する肌荒れ改善用であることを特徴とする、(1)又は(2)何れかに記載のTARC産生抑制剤。
ヒト皮膚由来表皮細胞株HaCaT cellを用いてTARC産生量の測定を実施した。10容量%牛胎児血清(GIBCO社製)を含むDMEM培地(GIBCO社製)に細胞を懸濁し、6ウェル培養プレートに0.5×10 6 の細胞数を播種し、CO 2 インキュベーター(95容量%空気、5容量%二酸化炭素)内、37℃の条件下で48時間培養した。その後、インターフェロン−γを終濃度10ng/ml、TNF−αを終濃度10ng/ml含有し、牛胎児血清を含まないDMEM培地に交換し、同時にジメチルスルホキ
シドにて懸濁した各成分を終濃度が0.5〜10μMとなるように添加し、さらに24時間培養した。培養上清を回収し、Quantakine Human TARC(R&D
systems社製)を用いてTARCを定量した(n=6)。結果は培地のみをコントロールとしたときの、コントロールに対する比で表した。
以下の表2に示す処方に従って、実施例2〜25として、本願発明の経口投与組成物を作製した。即ち、処方成分を10質量部の水と共に転動相造粒(不二パウダル株式会社製「ニューマルメライザー」)し、打錠して錠剤状の経口投与組成物を得た。本願発明の経口投与組成物は、血中TARC値の抑制作用に優れた効果を示していた。
以下の表5に示す処方に従って、実施例26〜49として、本願発明のドリンク製剤の経口投与組成物を作製した。即ち、処方成分を撹拌可溶化しドリンク製剤の経口投与組成物を得た。本願発明の経口投与組成物は、血中TARC値の抑制作用に優れた効果を示していた。
Claims (1)
- 次に示す成分の1種又は2種以上から選択される成分を含有することを特徴とする、アレルギー性疾患を有さない健常者に対するものである、TARC産生抑制剤。
(成分)エピカテキンガレート、エピガロカテキン、エピガロカテキンガレート、エピガロカテキン−3−O−(3−O−メチル)ガレート
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