JP2022092966A - ジペプチジルペプチダーゼiv阻害剤、機能性表示食品 - Google Patents
ジペプチジルペプチダーゼiv阻害剤、機能性表示食品 Download PDFInfo
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Abstract
Description
(1)メチル化カテキンを有効成分として含有するジペプチジルペプチダーゼIV阻害剤。
(2)上記メチル化カテキンは、エピガロカテキン-3-O-(3-O-メチル)ガレートを含むことを特徴とする(1)記載のジペプチジルペプチダーゼIV阻害剤。
(3)メチル化カテキンを有効成分として含有し、ジペプチジルペプチダーゼIV阻害作用を示す機能性表示食品。
(4)上記メチル化カテキンは、エピガロカテキン-3-O-(3-O-メチル)ガレートを含むことを特徴とする(3)記載の機能性表示食品。
本発明に係るDPP-IV阻害剤及び機能性表示食品は、有効成分としてメチル化カテキンを含有している。メチル化カテキンは主としては、例えば、エピガロカテキン-3-O-(3-O-メチル)ガレート(以下、EGCG3”Meという)、エピカテキン-3-O-(3-O-メチル)ガレート(以下、ECG3”Meという)、エピカテキン-3-O-(4-O-メチル)ガレート(以下、ECG4”Meという)、エピガロカテキン-3-O-(4-O-メチル)ガレート(以下、EGCG4”Meという)、ガロカテキン-3-O-(3-O-メチル)ガレート(以下、GCG3”Meという)、カテキン-3-O-(3-O-メチル)ガレート(以下、CG3”Meという)、カテキン-3-O-(4-O-メチル)ガレート(以下、CG4”Meという)、又は、ガロカテキン-3-O-(4-O-メチル)ガレート(以下、GCG4”Meという)及びこれらの異性化体を挙げることができる。特に、有効成分としては、エピガロカテキン-3-O-(3-O-メチル)ガレート(EGCG3”Me)を含むことが好ましい。
本実施例では、メチル化カテキンを含む種々のカテキン類を用いて、それぞれのDPP-IV阻害活性を検討した。DPP-IV阻害活性は、市販のDPP (IV) Inhibitor Screening Assay Kit(Caymanchemical社製)を使用した。本実施例で供試したカテキン類は、Epicatechin-3-O-gallate(ECG)、Epicatechin(EC)、Epigallocatechin(EGC)、(-)-Epigallocatechin gallate(EGCG)、(-)-Epigallocatechin 3-(3”-O-methyl)gallate(EGCG3”Me)である。これらカテキン類は長良サイエンス社から購入した。また、供試したCaffeineはSigma-Aldrich社から購入し、L-Theanineは富士フイルム和光純薬社から購入した。
Claims (4)
- メチル化カテキンを有効成分として含有するジペプチジルペプチダーゼIV阻害剤。
- 上記メチル化カテキンは、エピガロカテキン-3-O-(3-O-メチル)ガレートを含むことを特徴とする請求項1記載のジペプチジルペプチダーゼIV阻害剤。
- メチル化カテキンを有効成分として含有し、ジペプチジルペプチダーゼIV阻害作用を示す機能性表示食品。
- 上記メチル化カテキンは、エピガロカテキン-3-O-(3-O-メチル)ガレートを含むことを特徴とする請求項3記載の機能性表示食品。
Priority Applications (3)
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JP2020205992A JP2022092966A (ja) | 2020-12-11 | 2020-12-11 | ジペプチジルペプチダーゼiv阻害剤、機能性表示食品 |
CN202111345938.3A CN114617871A (zh) | 2020-12-11 | 2021-11-15 | 二肽基肽酶iv抑制剂、功能性标示食品 |
US17/545,053 US20220184027A1 (en) | 2020-12-11 | 2021-12-08 | Dipeptidyl peptidase-iv inhibitor and food with function claims |
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JP2020205992A JP2022092966A (ja) | 2020-12-11 | 2020-12-11 | ジペプチジルペプチダーゼiv阻害剤、機能性表示食品 |
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JP (1) | JP2022092966A (ja) |
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JP4788994B2 (ja) * | 2005-01-26 | 2011-10-05 | 独立行政法人農業・食品産業技術総合研究機構 | 機能性飲食品 |
JP2005328848A (ja) * | 2005-06-29 | 2005-12-02 | National Agriculture & Bio-Oriented Research Organization | 抗アレルギー成分を含有する機能性飲食品 |
JP4272691B2 (ja) * | 2008-02-25 | 2009-06-03 | 独立行政法人農業・食品産業技術総合研究機構 | 機能性食品 |
JP5688233B2 (ja) * | 2010-04-23 | 2015-03-25 | ポーラ化成工業株式会社 | Tarc産生抑制剤 |
MX2017009589A (es) * | 2015-01-26 | 2018-06-20 | Kaleido Biosciences Inc | Preparaciones terapeuticas de glicanos y metodos relacionados con estas. |
JP2019147772A (ja) * | 2018-02-28 | 2019-09-05 | サッポロホールディングス株式会社 | ヘプシジン発現抑制剤、並びに鉄欠乏性貧血改善及び/又は予防用飲食品 |
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- 2021-11-15 CN CN202111345938.3A patent/CN114617871A/zh active Pending
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JP2007186462A (ja) * | 2006-01-13 | 2007-07-26 | National Agriculture & Food Research Organization | 抗アレルギー剤及びこれを含有する飲食品、外用剤、化粧料 |
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