KR101773208B1 - 질소 함유 스피로 고리 화합물 및 이의 의약 용도 - Google Patents

질소 함유 스피로 고리 화합물 및 이의 의약 용도 Download PDF

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Publication number
KR101773208B1
KR101773208B1 KR1020127001455A KR20127001455A KR101773208B1 KR 101773208 B1 KR101773208 B1 KR 101773208B1 KR 1020127001455 A KR1020127001455 A KR 1020127001455A KR 20127001455 A KR20127001455 A KR 20127001455A KR 101773208 B1 KR101773208 B1 KR 101773208B1
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South Korea
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pharmaceutically acceptable
solvate
acceptable salt
compound according
mixture
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Korean (ko)
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KR20120051649A (ko
Inventor
사토루 노지
마코토 시오자키
도모야 미우라
요시노리 하라
히로시 야마나카
가츠야 마에다
아키미 호리
마사후미 이노우에
야스노리 하세
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니뽄 다바코 산교 가부시키가이샤
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Application filed by 니뽄 다바코 산교 가부시키가이샤 filed Critical 니뽄 다바코 산교 가부시키가이샤
Publication of KR20120051649A publication Critical patent/KR20120051649A/ko
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Publication of KR101773208B1 publication Critical patent/KR101773208B1/ko
Assigned to 시오노기세야쿠 가부시키가이샤 reassignment 시오노기세야쿠 가부시키가이샤 권리의 전부이전등록 Assignors: 니뽄 다바코 산교 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020127001455A 2009-07-31 2010-07-30 질소 함유 스피로 고리 화합물 및 이의 의약 용도 Active KR101773208B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009179502 2009-07-31
JPJP-P-2009-179502 2009-07-31
US27413709P 2009-08-13 2009-08-13
US61/274,137 2009-08-13
PCT/JP2010/062873 WO2011013785A1 (ja) 2009-07-31 2010-07-30 含窒素スピロ環化合物及びその医薬用途

Publications (2)

Publication Number Publication Date
KR20120051649A KR20120051649A (ko) 2012-05-22
KR101773208B1 true KR101773208B1 (ko) 2017-08-31

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ID=43529436

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KR1020127001455A Active KR101773208B1 (ko) 2009-07-31 2010-07-30 질소 함유 스피로 고리 화합물 및 이의 의약 용도

Country Status (36)

Country Link
US (4) US8609647B2 (https=)
EP (3) EP3858349A1 (https=)
JP (9) JP5520158B2 (https=)
KR (1) KR101773208B1 (https=)
CN (1) CN102510865B (https=)
AR (1) AR077497A1 (https=)
AU (1) AU2010278066B2 (https=)
BR (1) BR112012002157B1 (https=)
CA (1) CA2767899C (https=)
CO (1) CO6491052A2 (https=)
CY (2) CY1118747T1 (https=)
DK (1) DK2460806T3 (https=)
ES (1) ES2616705T3 (https=)
FI (1) FIC20250012I1 (https=)
FR (1) FR25C1010I2 (https=)
HR (1) HRP20170447T1 (https=)
HU (2) HUE033070T2 (https=)
IL (1) IL217048A (https=)
LT (2) LT2460806T (https=)
ME (1) ME02667B (https=)
MX (1) MX2012001313A (https=)
MY (1) MY163495A (https=)
NL (1) NL301321I2 (https=)
NO (1) NO2025014I1 (https=)
NZ (1) NZ597994A (https=)
PE (1) PE20121276A1 (https=)
PL (1) PL2460806T3 (https=)
PT (1) PT2460806T (https=)
RS (1) RS55913B1 (https=)
RU (1) RU2630694C2 (https=)
SG (1) SG176918A1 (https=)
SI (1) SI2460806T1 (https=)
SM (1) SMT201700166T1 (https=)
TW (1) TWI466885B (https=)
WO (1) WO2011013785A1 (https=)
ZA (1) ZA201200689B (https=)

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EP2651417B1 (en) 2010-12-16 2016-11-30 Calchan Limited Ask1 inhibiting pyrrolopyrimidine derivatives
KR102032934B1 (ko) 2011-12-21 2019-10-16 지앙수 헨그루이 메디슨 컴퍼니 리미티드 피롤 6원 헤테로아릴 고리 유도체, 그의 제조 방법, 및 그의 의약 용도
US20140343034A1 (en) * 2013-04-25 2014-11-20 Japan Tobacco Inc. Skin barrier function improving agent
KR102306276B1 (ko) 2013-10-21 2021-09-30 니뽄 다바코 산교 가부시키가이샤 안질환의 치료제 또는 예방제
RU2674027C2 (ru) * 2014-05-28 2018-12-04 Астразенека Аб Способ получения AZD5363 (варианты) и применяемое в нем новое промежуточное соединение
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WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
KR102728341B1 (ko) 2015-09-24 2024-11-11 레오 파마 에이/에스 원형탈모증의 치료
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JP2019527232A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタムｎｍｄａ修飾因子及びこれを用いた方法
MX391179B (es) * 2016-11-23 2025-03-21 Jiangsu Hengrui Medicine Co Método de preparación e intermediario de derivado de un anillo heteroaromático de seis miembros pirrolo
CA3044771A1 (en) * 2016-12-21 2018-06-28 Japan Tobacco Inc. Crystalline forms of a janus kinase inhibitor
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