KR101765752B1 - 벤질 아랄킬 에터 화합물, 그의 제조방법, 중간체 화합물, 상기 화합물의 용도, 치료 및/또는 예방 방법, 상기 화합물을 포함하는 약학적 조성물 및 약 - Google Patents

벤질 아랄킬 에터 화합물, 그의 제조방법, 중간체 화합물, 상기 화합물의 용도, 치료 및/또는 예방 방법, 상기 화합물을 포함하는 약학적 조성물 및 약 Download PDF

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KR101765752B1
KR101765752B1 KR1020127007355A KR20127007355A KR101765752B1 KR 101765752 B1 KR101765752 B1 KR 101765752B1 KR 1020127007355 A KR1020127007355 A KR 1020127007355A KR 20127007355 A KR20127007355 A KR 20127007355A KR 101765752 B1 KR101765752 B1 KR 101765752B1
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delete delete
compound
compounds
benzyl
ethyl
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KR20120050490A (ko
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아르투어 프란쯔 케플러
세르지오 루이쯔 사쿠라이
마르시오 헨리꼬 자임
카르로스 에두아도 다 코스타 투자림
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바이오랩 세너스 팔마씨우티카 엘티디에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020127007355A 2009-08-28 2010-08-27 벤질 아랄킬 에터 화합물, 그의 제조방법, 중간체 화합물, 상기 화합물의 용도, 치료 및/또는 예방 방법, 상기 화합물을 포함하는 약학적 조성물 및 약 Active KR101765752B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI0904249-0A BRPI0904249B1 (pt) 2009-08-28 2009-08-28 Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica
BRPI0904249-0 2009-08-28
PCT/BR2010/000276 WO2011022798A1 (pt) 2009-08-28 2010-08-27 Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, compostos intermediários, uso dos referidos compostos, método de tratamento e/ou prevenção, composição farmacêutica e medicamento contendo os mesmos

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KR20120050490A KR20120050490A (ko) 2012-05-18
KR101765752B1 true KR101765752B1 (ko) 2017-08-07

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Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
CN102579829B (zh) * 2012-03-06 2013-09-18 康莉 一种治疗牛放线菌病的中药组合物及其制备方法
CN104016837B (zh) * 2014-05-26 2016-08-24 武汉有机实业有限公司 4,4’-二甲基二苄基醚的制备方法
RU2603622C1 (ru) * 2015-06-25 2016-11-27 Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" Комплексный метод лечения тейлериоза мелкого рогатого скота
CN108047147A (zh) * 2017-12-08 2018-05-18 长江大学 一类三唑类化合物以及作为杀菌剂的用途
KR101983575B1 (ko) * 2017-12-21 2019-06-03 대한민국 신균주 세라토바시디움 속 js1289 및 이의 용도
CN114222573A (zh) * 2019-08-16 2022-03-22 普度研究基金会 蛋白酶体核心颗粒的小分子刺激物
JP2023057423A (ja) * 2021-10-11 2023-04-21 国立大学法人 熊本大学 ムコール症治療薬
CN117945867B (zh) * 2024-01-12 2026-06-12 海南师范大学 一种抗菌活性苄基苯醚类衍生物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065385A2 (en) 1981-05-07 1982-11-24 Syntex (U.S.A.) Inc. Methods and compositions for intravaginal contraception
WO2010007381A1 (en) 2008-07-18 2010-01-21 E-Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1170188A (en) 1967-09-15 1969-11-12 Bayer Ag N-trityl-imidazoles and salts and uses thereof
SU557755A3 (ru) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Способ получени производных имидазола
DE2333354C2 (de) * 1973-06-30 1983-12-15 Bayer Ag, 5090 Leverkusen 2-Aryloxy-2-(imidazol-1-yl)-äthanole sowie deren Salze, Verfahren zu ihrer Herstellung und ihre Verwendung als Fungizide
GB1475271A (en) 1975-04-30 1977-06-01 Pfizer Ltd 1-aryl-2-1-imidazolyl-alkyl ethers and thioethers and their use as antifungal agents
DE2556319A1 (de) * 1975-12-13 1977-06-23 Basf Ag Substituierte triazol-aether
US4144346A (en) 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4218458A (en) 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4277475A (en) * 1979-01-11 1981-07-07 Syntex (U.S.A.) Inc. Contraceptive methods employing 1-substituted imidazole derivatives
BE885957A (nl) 1980-10-31 1981-04-30 Amylum Graanderivaten Raff Inrichting voor de continue bereiding van zetmeellijm
DE3314738A1 (de) * 1983-04-23 1984-10-25 Bayer Ag, 5090 Leverkusen Azolylethyl-benzyl-ether-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US5278175A (en) 1990-02-02 1994-01-11 Pfizer Inc. Triazole antifungal agents
JP2875140B2 (ja) * 1993-08-16 1999-03-24 明治製菓株式会社 抗mrsa組成物
US5461068A (en) 1993-09-29 1995-10-24 Corwood Laboratories, Inc. Imidazole derivative tincture and method of manufacture
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
WO2006081327A2 (en) * 2005-01-25 2006-08-03 University Of Vermont And State Agricultural College Small molecules that reduce fungal growth
US20080233053A1 (en) * 2005-02-07 2008-09-25 Pharmalight Inc. Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
GB0714226D0 (en) * 2007-07-20 2007-08-29 Therapeutics Ltd E anti-bacterial combination therapy
GB0724996D0 (en) * 2007-12-21 2008-01-30 Therapeutics Ltd E Antibacterial combination therapy for the treatment of gram positive bacterial infections
CA2735460A1 (en) * 2008-08-29 2010-03-04 The Uab Research Foundation Novel anti-arrhythmia agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065385A2 (en) 1981-05-07 1982-11-24 Syntex (U.S.A.) Inc. Methods and compositions for intravaginal contraception
WO2010007381A1 (en) 2008-07-18 2010-01-21 E-Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
[논문] Bioorganic & Medicinal Chemistry Letters 2007, Vol.17(8), pp.2233-2236 (2007.04.15. 공개)

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AR078115A1 (es) 2011-10-12
HUE032199T2 (en) 2017-08-28
AU2010286266A1 (en) 2012-04-05
KR20120050490A (ko) 2012-05-18
RU2012110925A (ru) 2013-10-10
DK2471781T3 (da) 2017-01-02
EP2471781A1 (en) 2012-07-04
IN2012DN00611A (enExample) 2015-06-12
EP2471781B1 (en) 2016-09-07
JP5718334B2 (ja) 2015-05-13
US8975289B2 (en) 2015-03-10
IL218044A0 (en) 2012-04-30
CL2012000463A1 (es) 2012-09-21
US20120196908A1 (en) 2012-08-02
CA2771044A1 (en) 2011-03-03
IL218044A (en) 2017-02-28
BRPI0904249B1 (pt) 2018-03-06
SG178298A1 (en) 2012-03-29
UA108479C2 (en) 2015-05-12
EP2471781A4 (en) 2013-01-23
MX2012002276A (es) 2012-04-19
ZA201201442B (en) 2012-10-31
CA2771044C (en) 2017-07-04
CN102625800A (zh) 2012-08-01
RU2548009C2 (ru) 2015-04-10
WO2011022798A1 (pt) 2011-03-03
ES2606168T3 (es) 2017-03-23
BRPI0904249A2 (pt) 2011-05-17
PE20120921A1 (es) 2012-08-01
JP2013503111A (ja) 2013-01-31

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