JP5718334B2 - アラルキルベンジルエーテル化合物、その製造方法、中間体化合物、そのような化合物の使用、治療および／または予防の方法、それを含む薬学的組成物および医薬 - Google Patents

アラルキルベンジルエーテル化合物、その製造方法、中間体化合物、そのような化合物の使用、治療および／または予防の方法、それを含む薬学的組成物および医薬 Download PDF

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JP5718334B2
JP5718334B2 JP2012525824A JP2012525824A JP5718334B2 JP 5718334 B2 JP5718334 B2 JP 5718334B2 JP 2012525824 A JP2012525824 A JP 2012525824A JP 2012525824 A JP2012525824 A JP 2012525824A JP 5718334 B2 JP5718334 B2 JP 5718334B2
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ethyl
benzyl
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JP2013503111A5 (enExample
JP2013503111A (ja
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ケップレル、アルトゥール・フランツ
サクライ、セルジオ・ルイス
ツァイム、マルシオ・ヘンリク
トウサリム、カルロス・エデュアルド・ダ・コスタ
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バイオラブ・サヌス・ファーマセウティカ・エルティーディーエー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
    • C07C22/08—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2012525824A 2009-08-28 2010-08-27 アラルキルベンジルエーテル化合物、その製造方法、中間体化合物、そのような化合物の使用、治療および／または予防の方法、それを含む薬学的組成物および医薬 Active JP5718334B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI0904249-0A BRPI0904249B1 (pt) 2009-08-28 2009-08-28 Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica
BRPI0904249-0 2009-08-28
PCT/BR2010/000276 WO2011022798A1 (pt) 2009-08-28 2010-08-27 Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, compostos intermediários, uso dos referidos compostos, método de tratamento e/ou prevenção, composição farmacêutica e medicamento contendo os mesmos

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JP2013503111A JP2013503111A (ja) 2013-01-31
JP2013503111A5 JP2013503111A5 (enExample) 2013-10-10
JP5718334B2 true JP5718334B2 (ja) 2015-05-13

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JP2012525824A Active JP5718334B2 (ja) 2009-08-28 2010-08-27 アラルキルベンジルエーテル化合物、その製造方法、中間体化合物、そのような化合物の使用、治療および／または予防の方法、それを含む薬学的組成物および医薬

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US (1) US8975289B2 (enExample)
EP (1) EP2471781B1 (enExample)
JP (1) JP5718334B2 (enExample)
KR (1) KR101765752B1 (enExample)
CN (1) CN102625800A (enExample)
AR (1) AR078115A1 (enExample)
AU (1) AU2010286266B2 (enExample)
BR (1) BRPI0904249B1 (enExample)
CA (1) CA2771044C (enExample)
CL (1) CL2012000463A1 (enExample)
DK (1) DK2471781T3 (enExample)
ES (1) ES2606168T3 (enExample)
HU (1) HUE032199T2 (enExample)
IL (1) IL218044A (enExample)
IN (1) IN2012DN00611A (enExample)
MX (1) MX2012002276A (enExample)
PE (1) PE20120921A1 (enExample)
PL (1) PL2471781T3 (enExample)
PT (1) PT2471781T (enExample)
RU (1) RU2548009C2 (enExample)
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UA (1) UA108479C2 (enExample)
WO (1) WO2011022798A1 (enExample)
ZA (1) ZA201201442B (enExample)

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CN102579829B (zh) * 2012-03-06 2013-09-18 康莉 一种治疗牛放线菌病的中药组合物及其制备方法
CN104016837B (zh) * 2014-05-26 2016-08-24 武汉有机实业有限公司 4,4’-二甲基二苄基醚的制备方法
RU2603622C1 (ru) * 2015-06-25 2016-11-27 Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" Комплексный метод лечения тейлериоза мелкого рогатого скота
CN108047147A (zh) * 2017-12-08 2018-05-18 长江大学 一类三唑类化合物以及作为杀菌剂的用途
KR101983575B1 (ko) * 2017-12-21 2019-06-03 대한민국 신균주 세라토바시디움 속 js1289 및 이의 용도
CN114222573A (zh) * 2019-08-16 2022-03-22 普度研究基金会 蛋白酶体核心颗粒的小分子刺激物
JP2023057423A (ja) * 2021-10-11 2023-04-21 国立大学法人 熊本大学 ムコール症治療薬
CN117945867B (zh) * 2024-01-12 2026-06-12 海南师范大学 一种抗菌活性苄基苯醚类衍生物及其制备方法

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PT2471781T (pt) 2016-12-15
PL2471781T3 (pl) 2017-08-31
AU2010286266B2 (en) 2015-02-12
AR078115A1 (es) 2011-10-12
HUE032199T2 (en) 2017-08-28
AU2010286266A1 (en) 2012-04-05
KR20120050490A (ko) 2012-05-18
RU2012110925A (ru) 2013-10-10
DK2471781T3 (da) 2017-01-02
EP2471781A1 (en) 2012-07-04
KR101765752B1 (ko) 2017-08-07
IN2012DN00611A (enExample) 2015-06-12
EP2471781B1 (en) 2016-09-07
US8975289B2 (en) 2015-03-10
IL218044A0 (en) 2012-04-30
CL2012000463A1 (es) 2012-09-21
US20120196908A1 (en) 2012-08-02
CA2771044A1 (en) 2011-03-03
IL218044A (en) 2017-02-28
BRPI0904249B1 (pt) 2018-03-06
SG178298A1 (en) 2012-03-29
UA108479C2 (en) 2015-05-12
EP2471781A4 (en) 2013-01-23
MX2012002276A (es) 2012-04-19
ZA201201442B (en) 2012-10-31
CA2771044C (en) 2017-07-04
CN102625800A (zh) 2012-08-01
RU2548009C2 (ru) 2015-04-10
WO2011022798A1 (pt) 2011-03-03
ES2606168T3 (es) 2017-03-23
BRPI0904249A2 (pt) 2011-05-17
PE20120921A1 (es) 2012-08-01
JP2013503111A (ja) 2013-01-31

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