KR101752014B1 - 고용량 및 저용량 약물들의 조합을 포함하는 구강붕해정 조성물 - Google Patents

고용량 및 저용량 약물들의 조합을 포함하는 구강붕해정 조성물 Download PDF

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KR101752014B1
KR101752014B1 KR1020117028537A KR20117028537A KR101752014B1 KR 101752014 B1 KR101752014 B1 KR 101752014B1 KR 1020117028537 A KR1020117028537 A KR 1020117028537A KR 20117028537 A KR20117028537 A KR 20117028537A KR 101752014 B1 KR101752014 B1 KR 101752014B1
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coating
dose drug
drug
water
rti
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KR20120034630A (ko
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고피 엠. 벤카테쉬
제임스 클레벤져
마이클 고쎌린
진-웡 라이
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아데어 파마슈티컬스 인코포레이티드
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Epidemiology (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020117028537A 2009-05-01 2010-05-03 고용량 및 저용량 약물들의 조합을 포함하는 구강붕해정 조성물 Expired - Fee Related KR101752014B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17478809P 2009-05-01 2009-05-01
US17478009P 2009-05-01 2009-05-01
US61/174,780 2009-05-01
US61/174,788 2009-05-01
PCT/US2010/033389 WO2010127345A2 (en) 2009-05-01 2010-05-03 Orally disintegrating tablet compositions comprising combinations of high and low-dose drugs

Publications (2)

Publication Number Publication Date
KR20120034630A KR20120034630A (ko) 2012-04-12
KR101752014B1 true KR101752014B1 (ko) 2017-06-28

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KR1020117028537A Expired - Fee Related KR101752014B1 (ko) 2009-05-01 2010-05-03 고용량 및 저용량 약물들의 조합을 포함하는 구강붕해정 조성물
KR1020117028540A Ceased KR20120031002A (ko) 2009-05-01 2010-05-03 비-아편계 및 아편계 진통제의 조합을 포함하는 구강붕해정 조성물

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US (2) US20100330150A1 (enExample)
EP (2) EP2424504A4 (enExample)
JP (2) JP5845173B2 (enExample)
KR (2) KR101752014B1 (enExample)
CN (3) CN102458117B (enExample)
AR (2) AR076540A1 (enExample)
AU (2) AU2010242748B2 (enExample)
BR (1) BRPI1007636A2 (enExample)
CA (2) CA2760614A1 (enExample)
MX (2) MX2011011480A (enExample)
RU (2) RU2567032C2 (enExample)
TW (2) TW201041607A (enExample)
WO (2) WO2010127345A2 (enExample)
ZA (2) ZA201108780B (enExample)

Families Citing this family (60)

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Publication number Priority date Publication date Assignee Title
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
CA2687979C (en) 2007-05-25 2017-07-04 Tolmar Therapeutics, Inc. Sustained delivery formulations of risperidone compounds
AU2010242748B2 (en) * 2009-05-01 2015-07-23 Adare Pharmaceuticals, Inc. Orally disintegrating tablet compositions comprising combinations of high and low-dose drugs
US8901113B2 (en) 2009-09-30 2014-12-02 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
JP5854476B2 (ja) * 2009-11-30 2016-02-09 アデア ファーマスーティカルズ，インコーポレイテッド 圧縮性コーティングで被覆された医薬組成物及び錠剤並びに製造方法
EP2547206B1 (en) * 2010-03-15 2016-05-11 Inventia Healthcare Private Limited Stabilized prolonged release pharmaceutical composition comprising atypical antipsychotic
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
PL2593081T3 (pl) * 2010-07-15 2014-08-29 Tedec Meiji Farma S A Kompozycja tabletki żelazo-mannitol-owoalbumina
KR20120135063A (ko) * 2011-06-01 2012-12-12 닛토덴코 가부시키가이샤 입자 제제 및 그 제조 방법
US20150238615A1 (en) * 2011-12-12 2015-08-27 Leonard Mackles Denaturants for sympathomimetic amines
US10105330B2 (en) * 2012-01-04 2018-10-23 Wellesley Pharmaceuticals, Llc Extended, delayed and immediate release formulation method of manufacturing and use thereof
EP2833880B1 (en) * 2012-04-02 2017-08-23 Pharma Seeds Create, LLC Ibuprofen solid oral dosage composition comprising a methacrylic acid copolymer
US9301016B2 (en) * 2012-04-05 2016-03-29 Facebook, Inc. Sharing television and video programming through social networking
KR101397343B1 (ko) * 2012-06-12 2014-05-19 씨제이제일제당 (주) 메트포르민 및 ＨＭＧ―ＣｏＡ 환원효소 억제제를 포함하는 약제학적 복합제제
KR20140013436A (ko) * 2012-07-24 2014-02-05 한미약품 주식회사 메트포르민 및 로수바스타틴을 포함하는 경구용 복합 제제
US8993041B2 (en) * 2012-10-15 2015-03-31 New Jersey Institute Of Technology Taste masked active pharmaceutical powder compositions and processes for making them
CN104968333B (zh) 2012-11-30 2018-07-10 阿库拉制药公司 活性药物成分的自调节释放
US20150005334A1 (en) * 2013-03-15 2015-01-01 Inspirion Delivery Technologies, Llc Abuse deterrent compositions and methods of use
US10420726B2 (en) * 2013-03-15 2019-09-24 Inspirion Delivery Sciences, Llc Abuse deterrent compositions and methods of use
KR102240429B1 (ko) * 2013-05-06 2021-04-15 한미약품 주식회사 로수바스타틴 또는 이의 약학적으로 허용되는 염이 함유된 필름 코팅층을 포함하는 복합 제형
WO2014182003A1 (en) * 2013-05-06 2014-11-13 Hanmi Pharm. Co., Ltd. Composite formulation comprising a film coating layer containing rosuvastatin or a pharmaceutically acceptable salt thereof
US9737490B2 (en) * 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
CA2919892C (en) 2013-08-12 2019-06-18 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
KR101639692B1 (ko) 2013-12-13 2016-07-14 제일약품주식회사 2 이상의 유효성분을 포함하는 구강 내 속붕해 다중유닛 약제학적 조성물
MX2016007786A (es) * 2013-12-16 2017-03-03 Massachusetts Inst Technology Formulaciones de sal de micronutrientes fortificadas.
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
EP3106152B1 (en) * 2014-02-12 2021-02-17 Sawai Pharmaceutical Co., Ltd. Orally disintegrating tablet coated with film
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
EP3122336A4 (en) 2014-03-26 2017-10-25 Sun Pharma Advanced Research Company Ltd Abuse deterrent immediate release biphasic matrix solid dosage form
US20180104197A9 (en) * 2014-05-01 2018-04-19 Sun Pharmaceutical Industries Limited Extended release liquid compositions of metformin
US9962336B2 (en) 2014-05-01 2018-05-08 Sun Pharmaceutical Industries Limited Extended release suspension compositions
RU2016147009A (ru) 2014-05-01 2018-06-04 Сан Фармасьютикал Индастриз Лимитед Композиции с пролонгированным высвобождением в виде суспензии
US10258583B2 (en) 2014-05-01 2019-04-16 Sun Pharmaceutical Industries Limited Extended release liquid compositions of guanfacine
DK3169315T3 (da) 2014-07-17 2020-08-10 Pharmaceutical Manufacturing Res Services In Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse
CA2956902A1 (en) 2014-07-30 2016-02-04 Sun Pharmaceutical Industries Limited Dual-chamber pack
US9132096B1 (en) * 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
WO2016051279A1 (en) * 2014-10-02 2016-04-07 Lacey Stuart H Systems and methods for context-based permissioning of personally identifiable information
EP3209282A4 (en) 2014-10-20 2018-05-23 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
WO2017040607A1 (en) 2015-08-31 2017-03-09 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
WO2017047586A1 (ja) * 2015-09-14 2017-03-23 日本新薬株式会社 錠剤
WO2017064815A1 (ja) * 2015-10-16 2017-04-20 持田製薬株式会社 低用量薬物を含有する口腔内崩壊錠
MX383987B (es) * 2015-12-28 2025-03-14 Ssp Co Ltd Japan Preparación farmacéutica compactada.
JP6812104B2 (ja) * 2015-12-28 2021-01-13 エスエス製薬株式会社 経口固形組成物
US10369078B2 (en) 2016-05-02 2019-08-06 Sun Pharmaceutical Industries Limited Dual-chamber pack for pharmaceutical compositions
US10238803B2 (en) 2016-05-02 2019-03-26 Sun Pharmaceutical Industries Limited Drug delivery device for pharmaceutical compositions
CN106619696A (zh) * 2016-11-17 2017-05-10 郑州郑先医药科技有限公司 一种降血糖的复方制剂
US20180256515A1 (en) 2017-03-10 2018-09-13 Adare Pharmaceuticals, Inc. Oral amphetamine composition
CN107224439A (zh) * 2017-06-13 2017-10-03 江苏黄河药业股份有限公司 一种用于治疗过敏性疾病的氯雷他定口腔崩解片及其制备方法
WO2019131891A1 (ja) * 2017-12-28 2019-07-04 大日本住友製薬株式会社 苦味がマスキングされた薬物含有粒子及び該薬物含有粒子を含む製剤
WO2019155334A1 (en) * 2018-02-06 2019-08-15 3M Innovative Properties Company Microcapsule with a porous or hollow core and ph-sensitive shell use thereof
CN110840850B (zh) * 2018-07-24 2023-03-17 烟台药物研究所 一种高生物利用度的塞来昔布冻干口崩片及其制备方法
CN109701461B (zh) * 2018-10-25 2021-06-08 西南交通大学 一种基于PEG/Dex双水相的碳酸钙/海藻酸钙复合微囊的制备及其应用
CN109776873B (zh) * 2018-12-12 2020-10-27 华南理工大学 乳液溶剂挥发法制备大孔聚合物微球
FR3093419B1 (fr) * 2019-03-08 2021-06-18 Univ Grenoble Alpes Composition et procédé associé de mesure de l’observance thérapeutique
WO2023095183A1 (en) * 2021-11-24 2023-06-01 Jordan University Of Science And Technology A pharmaceutical composition and a solid dosage form thereof
WO2024118889A2 (en) * 2022-12-01 2024-06-06 Michael Ogburn Inhalable hormone receptor agonist formulations
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210714B1 (en) 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating
US6485747B1 (en) 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4891223A (en) * 1987-09-03 1990-01-02 Air Products And Chemicals, Inc. Controlled release delivery coating formulation for bioactive substances
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
ATE359785T1 (de) * 1997-07-31 2007-05-15 Kos Life Sciences Inc Manteltablette enthaltend nikotinsäure oder einen stoff, der zu nikotinsäure metabolisiert wird, in verzögert freigesetzter form, und einen hmg-coa reduktasehemmer im mantel zur sofortigen freisetzung
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
AU2001257456B2 (en) * 2000-05-01 2006-02-09 Aeropharm Technology, Inc. A core formulation
ATE381963T1 (de) * 2001-10-26 2008-01-15 Octoplus Technologies B V Verfahren zur herstellung von gereinigten partikeln
EP1350512A1 (en) * 2002-04-03 2003-10-08 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Combinations of epinastine, belladonna and pseudoephedrine as new pharmaceutical formulations
MXPA04011007A (es) * 2002-05-09 2005-02-14 Oncolytics Biotech Inc Metodo para reducir el dolor usando virus oncoliticos.
FR2850576B1 (fr) * 2003-02-05 2007-03-23 Ethypharm Sa Composition comprenant un melange de principes actifs, et procede de preparation
WO2004110411A2 (fr) * 2003-06-06 2004-12-23 Ethypharm Comprime orodispersible multicouche
FR2855756B1 (fr) * 2003-06-06 2005-08-26 Ethypharm Sa Comprime orodispersible multicouche
US7387793B2 (en) * 2003-11-14 2008-06-17 Eurand, Inc. Modified release dosage forms of skeletal muscle relaxants
TW200616604A (en) * 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
CN100404025C (zh) * 2005-01-14 2008-07-23 信谊药厂 含有盐酸曲马多和对乙酰氨基酚的口崩片及其制备方法
KR101408315B1 (ko) * 2006-08-04 2014-06-20 에씨팜 다층 경구 붕해 정제
EA017832B1 (ru) * 2006-08-04 2013-03-29 Этифарм Гранулы и орально дезинтегрируемые таблетки, содержащие оксикодон
CN101352425B (zh) * 2007-07-27 2010-11-10 鲁南制药集团股份有限公司 一种复方渗透泵控释制剂及其制备方法
AU2010242748B2 (en) * 2009-05-01 2015-07-23 Adare Pharmaceuticals, Inc. Orally disintegrating tablet compositions comprising combinations of high and low-dose drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210714B1 (en) 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating
US6485747B1 (en) 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)

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