KR101720961B1 - 다능성 세포의 분화 - Google Patents
다능성 세포의 분화 Download PDFInfo
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- KR101720961B1 KR101720961B1 KR1020117022315A KR20117022315A KR101720961B1 KR 101720961 B1 KR101720961 B1 KR 101720961B1 KR 1020117022315 A KR1020117022315 A KR 1020117022315A KR 20117022315 A KR20117022315 A KR 20117022315A KR 101720961 B1 KR101720961 B1 KR 101720961B1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/14—Erythropoietin [EPO]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15630409P | 2009-02-27 | 2009-02-27 | |
| US61/156,304 | 2009-02-27 | ||
| PCT/US2010/025776 WO2010099539A1 (en) | 2009-02-27 | 2010-03-01 | Differentiation of pluripotent cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110122858A KR20110122858A (ko) | 2011-11-11 |
| KR101720961B1 true KR101720961B1 (ko) | 2017-03-29 |
Family
ID=42097524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117022315A Active KR101720961B1 (ko) | 2009-02-27 | 2010-03-01 | 다능성 세포의 분화 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8372642B2 (enExample) |
| EP (1) | EP2401364B1 (enExample) |
| JP (2) | JP5816100B2 (enExample) |
| KR (1) | KR101720961B1 (enExample) |
| CN (1) | CN102388130B (enExample) |
| AU (1) | AU2010217739B2 (enExample) |
| CA (1) | CA2753679C (enExample) |
| IL (1) | IL214818A (enExample) |
| WO (1) | WO2010099539A1 (enExample) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102230288B1 (ko) | 2006-04-14 | 2021-03-22 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 혈관 콜로니 형성 세포 |
| JP5804280B2 (ja) * | 2009-09-08 | 2015-11-04 | 国立大学法人京都大学 | 多能性幹細胞からの肥満細胞の製造方法 |
| ES2779048T3 (es) | 2009-11-12 | 2020-08-13 | Technion Res & Dev Foundation | Medios de cultivo, cultivos celulares y métodos de cultivo de células madre pluripotentes en un estado indiferenciado |
| US8703487B2 (en) * | 2009-12-01 | 2014-04-22 | The Regents Of The University Of California | Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells |
| CA3095576A1 (en) * | 2009-12-04 | 2011-06-09 | Astellas Institute For Regenerative Medicine | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
| EP2539437B1 (en) | 2010-02-25 | 2017-08-02 | The Johns Hopkins University | SMOOTH MUSCLE-LIKE CELLS (SMLCs) DERIVED FROM HUMAN PLURIPOTENT STEM CELLS |
| CA2802249A1 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| EP2601289B1 (en) | 2010-08-04 | 2017-07-12 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
| EP2615165B1 (en) | 2010-09-10 | 2016-08-03 | The University of Tokyo | Culture method related to differentiation of pluripotent stem cells into blood cells |
| WO2012103098A2 (en) * | 2011-01-24 | 2012-08-02 | Immunepath, Inc. | Compositions and methods for treating hematological cytopenias |
| JP6148429B2 (ja) * | 2011-01-31 | 2017-06-14 | 協和発酵バイオ株式会社 | ヒト多能性幹細胞の培養方法 |
| US9574179B2 (en) * | 2011-02-08 | 2017-02-21 | Cellular Dynamics International, Inc. | Hematopoietic precursor cell production by programming |
| CN102161980B (zh) * | 2011-02-12 | 2013-07-31 | 浙江大学 | 用人间充质干细胞为滋养层培养诱导多能干细胞的方法 |
| US9499789B2 (en) | 2011-02-23 | 2016-11-22 | Kyoto University | Method for producing dendritic cells from pluripotent stem cells |
| GB201103600D0 (en) * | 2011-03-01 | 2011-04-13 | Isis Innovation | Dendritic cells |
| US9169309B2 (en) * | 2011-03-01 | 2015-10-27 | Humanzyme Inc. | Thermostable variants of fibroblast growth factors |
| WO2012135621A2 (en) * | 2011-03-30 | 2012-10-04 | Cellular Dynamics International. Inc | Priming of pluripotent stem cells for neural differentiation |
| BR112013030166A2 (pt) * | 2011-06-09 | 2017-03-21 | Hoffmann La Roche | método de diferenciação de células haste pluripotentes em células leito vasculares, células endoteliais ou células dos músculos moles vasculares, banco biológico e uso de células endoteliais ou células dos músculos moles vasculares, composição terapêutica, métodos e usos. |
| RU2616281C2 (ru) * | 2011-09-29 | 2017-04-13 | СЕЛЛСНЭП, ЭлЭлСи | Композиции и способы испытаний на токсикогенность |
| US20140227780A1 (en) * | 2011-10-03 | 2014-08-14 | Nissan Chemical Industries, Ltd. | Method for producing megakaryocytes and/or platelets from pluripotent stem cells |
| CN104053769A (zh) * | 2011-11-21 | 2014-09-17 | 大学健康网络 | 造血祖细胞群体和富集其干细胞的方法 |
| HRP20181515T1 (hr) | 2011-11-30 | 2018-11-16 | Astellas Institute For Regenerative Medicine | Mezenhimne stromalne stanice i upotreba povezana s njima |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| US10428309B2 (en) | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| US10273459B2 (en) | 2011-12-01 | 2019-04-30 | New York Stem Cell Foundation | Automated system for producing induced pluripotent stem cells or differentiated cells |
| CA2865497A1 (en) * | 2012-02-29 | 2013-09-06 | The Johns Hopkins University | Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation |
| US9260696B2 (en) | 2012-04-24 | 2016-02-16 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| WO2014011407A2 (en) | 2012-07-12 | 2014-01-16 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| JP6372782B2 (ja) * | 2012-09-28 | 2018-08-15 | 公益財団法人神戸医療産業都市推進機構 | 虚血性疾患治療に適した細胞を含む細胞群の生体外増幅方法 |
| WO2014079878A1 (en) | 2012-11-21 | 2014-05-30 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for determination of botulinum neurotoxin biological activity |
| CN114558032B (zh) | 2012-12-21 | 2025-07-29 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| PT2970912T (pt) * | 2013-03-13 | 2019-05-31 | Wisconsin Alumni Res Found | Métodos e materiais para a diferenciação hematoendotelial de células estaminais pluripotentes humanas em condições definidas |
| AU2014232381A1 (en) * | 2013-03-15 | 2015-10-29 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| US9994825B2 (en) | 2013-03-15 | 2018-06-12 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| US9506037B2 (en) | 2013-03-15 | 2016-11-29 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| CN105408472A (zh) * | 2013-03-15 | 2016-03-16 | 马卡斯凯尔·托莱夫·拉尔森 | 用于脐带血收集及细胞分离的细胞、方法和装置 |
| US9822342B2 (en) | 2013-05-14 | 2017-11-21 | Kyoto University | Method of efficiently inducing cardiomyocytes |
| JP5511039B1 (ja) * | 2013-05-22 | 2014-06-04 | 国立大学法人九州大学 | Nk細胞の調製方法 |
| US20160146788A1 (en) * | 2013-05-23 | 2016-05-26 | Kyoto University | Method for screening drugs for treating/preventing myelodysplastic syndrome, etc. |
| US10119122B2 (en) * | 2013-06-10 | 2018-11-06 | Academisch Ziekenhuis Leiden | Differentiation and expansion of endothelial cells from pluripotent stem cells and the in vitro formation of vasculature like structures |
| ES2699432T3 (es) | 2013-06-28 | 2019-02-11 | Merz Pharma Gmbh & Co Kgaa | Medios y métodos para la determinación de la actividad biológica de polipéptidos de neurotoxinas en células |
| WO2015050963A1 (en) | 2013-10-01 | 2015-04-09 | Manfred Boehm | Human ipsc-derived vascular-related and hematopoetic cells for therapies and toxicology/drug screenings |
| WO2015119642A1 (en) * | 2014-02-10 | 2015-08-13 | The Johns Hopkins University | Low oxygen tension enhances endothelial fate of human pluripotent stem cells |
| SG11201606810SA (en) | 2014-02-19 | 2016-09-29 | Merz Pharma Gmbh & Co Kgaa | Gangliosides for standardizing and increasing the sensitivity of cells to botulinum neurotoxins in in vitro test systems |
| KR20200138445A (ko) | 2014-04-24 | 2020-12-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용 |
| CN103937743B (zh) * | 2014-04-27 | 2017-12-01 | 浙江大学 | 一种利用三维诱导系统获得造血干细胞的方法 |
| WO2016020288A1 (en) | 2014-08-04 | 2016-02-11 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| ES2837699T3 (es) | 2014-12-19 | 2021-07-01 | Merz Pharma Gmbh & Co Kgaa | Medios y métodos para la determinación de la actividad biológica de BoNT/E en células |
| US10724003B2 (en) | 2015-01-16 | 2020-07-28 | Agency For Science, Technology And Research | Method of differentiating human pluripotent stem cells into primitive macrophages |
| US9828634B2 (en) | 2015-01-22 | 2017-11-28 | Regenerative Medical Solutions, Inc. | Markers for differentiation of stem cells into differentiated cell populations |
| CN114058582A (zh) | 2015-01-26 | 2022-02-18 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| TWI704156B (zh) | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
| WO2016187459A1 (en) * | 2015-05-20 | 2016-11-24 | The Regents Of The University Of California | Method for generating human dendritic cells for immunotherapy |
| EP4026563B1 (en) * | 2015-06-18 | 2025-10-29 | Yeda Research and Development Co. Ltd | Conditioning protocols and use of same for tissue regeneration |
| WO2017043604A1 (ja) * | 2015-09-08 | 2017-03-16 | 大日本住友製薬株式会社 | 網膜組織の製造方法 |
| CA3002157A1 (en) * | 2015-10-20 | 2017-04-27 | FUJIFILM Cellular Dynamics, Inc. | Methods for directed differentiation of pluripotent stem cells to immune cells |
| AU2016343682A1 (en) | 2015-10-30 | 2018-06-14 | The Regents Of The University Of California | Methods of generating T-cells from stem cells and immunotherapeutic methods using the T-cells |
| CN115806940A (zh) | 2015-11-04 | 2023-03-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| EP3371301A4 (en) | 2015-11-04 | 2019-06-26 | Fate Therapeutics, Inc. | METHOD AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS |
| CN105296428A (zh) * | 2015-12-03 | 2016-02-03 | 广州医科大学附属第三医院 | 一种提高诱导多能干细胞的体外分化造血效率的方法 |
| JP6979687B2 (ja) * | 2015-12-29 | 2021-12-15 | アイ ピース インク | 幹細胞の凝集塊の集団の調製方法 |
| GB201601503D0 (en) | 2016-01-27 | 2016-03-09 | Isis Innovation | Dendritic cells |
| DK3460042T3 (da) | 2016-05-18 | 2024-03-11 | Univ Keio | Celledyrkningsmedium til dyrkning af et organoid, dyrkningsfremgnagsmåde og organoid |
| JP7039473B2 (ja) * | 2016-07-29 | 2022-03-22 | ダイキン工業株式会社 | 分化細胞の製造方法、及びその製造方法のために使用する培養バッグ |
| CN109963940A (zh) * | 2016-09-02 | 2019-07-02 | 宝生物工程株式会社 | 从多能干细胞获得小胶质细胞的方法 |
| US11525119B2 (en) | 2016-09-06 | 2022-12-13 | The Children's Medical Center Corporation | Immune cells derived from induced pluripotent stem cell |
| JP7212615B2 (ja) * | 2016-10-05 | 2023-01-25 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | 多能性幹細胞からhlaホモ接合免疫細胞への指向分化方法 |
| CN110050061A (zh) * | 2016-10-05 | 2019-07-23 | 富士胶片细胞动力公司 | 从具有MeCP2破坏的诱导多能干细胞生成成熟谱系 |
| CN106479968A (zh) * | 2016-10-11 | 2017-03-08 | 海南博鳌龄迈迪精准医学研究院有限公司 | 脐带间充质干细胞的培养方法 |
| WO2018073615A1 (en) | 2016-10-21 | 2018-04-26 | Longboat Explorers Ab | Methods and compositions for generating hematopoietic cells |
| CN106754684A (zh) * | 2017-01-05 | 2017-05-31 | 厚朴生物科技(苏州)有限公司 | 一种睾丸间质干细胞分离培养分化方法 |
| WO2018139600A1 (ja) | 2017-01-27 | 2018-08-02 | 株式会社カネカ | 内胚葉系細胞集団、及び多能性細胞から三胚葉のいずれかの細胞集団を製造する方法 |
| US11932876B2 (en) * | 2017-02-03 | 2024-03-19 | Cornell University | Stable three-dimensional blood vessels and methods for forming the same |
| US20200080058A1 (en) * | 2017-03-21 | 2020-03-12 | Etablissement Francais Du Sang | Methods of improving hematopoietic grafts |
| EA201992469A1 (ru) | 2017-04-18 | 2020-05-27 | Фуджифилм Селльюлар Дайнамикс, Инк. | Антигенспецифические иммунные эффекторные клетки |
| EP3399027A1 (en) | 2017-05-04 | 2018-11-07 | Medizinische Hochschule Hannover | Stem-cell derived myeloid cells, generation and use thereof |
| CN107083367B (zh) * | 2017-07-03 | 2020-07-14 | 广州润虹医药科技股份有限公司 | 培养基及其用途与由尿液细胞制备间充质干细胞的方法 |
| US20200131476A1 (en) * | 2017-12-11 | 2020-04-30 | Korea Center For Disease Control And Prevention | Differentiation Of Immunocytes Using Pluripotent Stem Cells |
| WO2019126146A1 (en) | 2017-12-19 | 2019-06-27 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| CN108048390B (zh) * | 2017-12-21 | 2021-04-27 | 清华大学 | 一种制备血管内皮细胞的方法及其专用试剂盒 |
| CN108588024B (zh) * | 2017-12-29 | 2020-04-21 | 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) | 诱导多能干细胞分化成造血干细胞的培养基及方法 |
| JP2021509812A (ja) | 2018-01-05 | 2021-04-08 | プレートレット バイオジェネシス, インコーポレイテッド | 巨核球を産生するための組成物および方法 |
| NZ766453A (en) | 2018-02-01 | 2022-02-25 | Nkmax Co Ltd | Method of producing natural killer cells and composition for treating cancer |
| FR3079239A1 (fr) * | 2018-03-23 | 2019-09-27 | Centre National De La Recherche Scientifique | Nouvelle methode d’obtention de cellules t a partir de cellules souches pluripotentes, et leurs utilisations |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| IL281413B2 (en) | 2018-09-19 | 2024-09-01 | Fujifilm Cellular Dynamics Inc | Protein l for activation and expansion of chimeric antigen receptor-modified immune cells |
| CN109266618B (zh) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | 能够靶向肿瘤细胞的巨噬细胞及其制备方法 |
| AU2019368313A1 (en) * | 2018-10-24 | 2021-05-20 | Hebecell Corporation | Methods and systems for manufacturing hematopoietic lineage cells |
| KR102111441B1 (ko) * | 2018-11-12 | 2020-05-15 | 대한민국 | 전분화능 줄기세포 유래 대식세포를 기반으로 하는 감염질환 치료용 약물 스크리닝 방법 |
| US12258583B2 (en) | 2018-12-20 | 2025-03-25 | Sumitomo Chemical Company, Limited | Embryonic erythroblast-containing cell population and method for producing same, cell culture composition, and compound test method |
| JP7634938B2 (ja) * | 2019-02-21 | 2025-02-25 | ピービーエス バイオテック インコーポレイテッド | バイオリアクターにおける治療細胞の膨張および分化のためのシステムおよび方法 |
| CN111206017B (zh) * | 2019-04-30 | 2022-02-18 | 浙江大学 | 一种干细胞无血清培养基及其应用 |
| KR20220032561A (ko) * | 2019-06-14 | 2022-03-15 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 하전된 표면을 사용하여 유도 만능 줄기 세포로부터 다중 계통을 생산하는 방법 |
| EP3986358A4 (en) | 2019-06-20 | 2023-06-21 | Amniotics AB | DEVICE FOR FILTERING FRUIT WATER |
| CN114765957B (zh) | 2019-10-18 | 2025-09-12 | Amniotics公司 | 从羊水中获得羊膜间充质干细胞的方法和设备及其来源的细胞 |
| WO2021096218A1 (ko) * | 2019-11-13 | 2021-05-20 | 연세대학교 산학협력단 | 혈관 내피세포 순수 분리 방법, 혈관 내피세포 특성 유지 배지 및 이를 포함하는 배양 방법 |
| CN110938584B (zh) * | 2019-11-25 | 2021-12-03 | 广州赛莱拉干细胞科技股份有限公司 | 一种人胚胎干细胞向内皮细胞诱导分化的方法 |
| EP4076657A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| JOP20220160A1 (ar) | 2019-12-20 | 2023-01-30 | Nuevolution As | مركبات فعّالة نحو مستقبلات نووية |
| CN115135754A (zh) * | 2020-02-28 | 2022-09-30 | 普渡研究基金会 | 在限定条件下从人多能干细胞生成主动脉-性腺-中肾样造血细胞 |
| US12220445B2 (en) | 2020-03-09 | 2025-02-11 | Amprion, Inc. | Inert matrices for qualitative and semi-quantitative seed amplification assays |
| CN111440760B (zh) * | 2020-03-09 | 2022-09-23 | 浙江大学 | 一种人多能干细胞高效分化得到内皮祖细胞的方法 |
| US11547726B2 (en) * | 2020-03-26 | 2023-01-10 | Honed Life Sciences, Llc | Enhancement of production of NK cells from stem cells |
| MX2022012260A (es) | 2020-03-31 | 2022-11-30 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| MX2022012259A (es) | 2020-03-31 | 2022-12-08 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| CN115885038A (zh) | 2020-06-17 | 2023-03-31 | 国立大学法人京都大学 | 表达嵌合抗原受体的免疫活性细胞 |
| CN116096858A (zh) * | 2020-07-27 | 2023-05-09 | 加拿大干细胞技术公司 | 用于分化造血细胞的系统和方法 |
| CN111808812B (zh) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | 一种用于多能干细胞向造血干细胞分化的材料和方法 |
| US12435308B2 (en) | 2020-11-06 | 2025-10-07 | Amniotics Ab | Immunomodulation by amniotic fluid mesenchymal stem cells |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| TW202237827A (zh) | 2020-12-03 | 2022-10-01 | 美商世紀治療股份有限公司 | 經基因工程改造之細胞及其用途 |
| CN112608895B (zh) * | 2020-12-18 | 2024-02-27 | 深圳市济因生物科技有限公司 | 一种人多能干细胞分化的自然杀伤细胞及其制备方法与应用 |
| US11473060B2 (en) | 2020-12-30 | 2022-10-18 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into NK cells |
| CA3214473A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells |
| AU2022253223A1 (en) | 2021-04-07 | 2023-09-28 | Century Therapeutics, Inc. | Combined artificial cell death/reporter system polypeptide for chimeric antigen receptor cell and uses thereof |
| MX2023011927A (es) | 2021-04-07 | 2023-10-23 | Century Therapeutics Inc | Composiciones y metodos para la generacion de linfocitos t gamma-delta a partir de celulas madre pluripotentes inducidas. |
| US20220331361A1 (en) | 2021-04-07 | 2022-10-20 | Century Therapeutics, Inc. | Gene transfer vectors and methods of engineering cells |
| JP2024516992A (ja) | 2021-05-05 | 2024-04-18 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | Ipsc由来ミクログリアのための方法及び組成物 |
| CA3231278A1 (en) | 2021-09-10 | 2023-03-16 | Deepika Rajesh | Compositions of induced pluripotent stem cell-derived cells and methods of use thereof |
| EP4402164A4 (en) * | 2021-09-13 | 2025-07-02 | Amprion Inc | INERT MATRICES FOR QUALITATIVE AND SEMI-QUANTITATIVE SEED AMPLIFICATION ASSAYS |
| WO2023110045A1 (en) | 2021-12-15 | 2023-06-22 | Y-Mabs Therapeutics, Inc. | Scfv and antibodies with reduced multimerisation |
| JP2025501214A (ja) | 2021-12-29 | 2025-01-17 | センチュリー セラピューティクス,インコーポレイテッド | 抗cd19/抗cd22キメラ抗原受容体を有する遺伝子操作細胞、およびその使用 |
| AU2023223404A1 (en) | 2022-02-22 | 2024-08-29 | Juno Therapeutics, Inc. | Proteinase 3 (pr3) chimeric autoantibody receptor t cells and related methods and uses |
| JP2025515095A (ja) | 2022-05-04 | 2025-05-13 | センチュリー セラピューティクス,インコーポレイテッド | Hla-eおよびhla-g導入遺伝子を用いて操作された細胞 |
| WO2023240169A1 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Immunoeffector cells derived from induced pluripotent stem cells genetically engineered with membrane bound il12 and uses thereof |
| WO2023240212A2 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof |
| CN119630695A (zh) | 2022-06-08 | 2025-03-14 | 世纪治疗股份有限公司 | 表达cd16变体和nkg2d的遗传工程化细胞及其用途 |
| WO2024102838A1 (en) | 2022-11-09 | 2024-05-16 | Century Therapeutics, Inc. | Engineered interleukin-7 receptors and uses thereof |
| JP2025537284A (ja) | 2022-11-10 | 2025-11-14 | センチュリー セラピューティクス,インコーポレイテッド | 抗ネクチン4キメラ抗原受容体を有する遺伝子操作細胞、およびその使用 |
| US20240269189A1 (en) | 2022-12-19 | 2024-08-15 | FUJIFILM Holdings America Corporation | Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof |
| AU2024223390A1 (en) * | 2023-02-16 | 2025-08-28 | Syntax Bio, Inc. | Systems for cell programming towards hematopoietic lineage and methods thereof |
| CN116426472A (zh) * | 2023-06-08 | 2023-07-14 | 呈诺再生医学科技(北京)有限公司 | 一种促进造血干细胞或造血祖细胞分化为红细胞的诱导分化体系及其应用 |
| WO2025101938A2 (en) | 2023-11-10 | 2025-05-15 | Century Therapeutics, Inc. | Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof |
| WO2025106626A1 (en) | 2023-11-15 | 2025-05-22 | Century Therapeutics, Inc. | Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof |
| WO2025207795A1 (en) | 2024-03-26 | 2025-10-02 | Juno Therapeutics, Inc. | Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof |
| WO2025207798A1 (en) | 2024-03-26 | 2025-10-02 | Century Therapeutics, Inc. | Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3583287D1 (de) | 1984-12-27 | 1991-07-25 | Asahi Chemical Ind | Substituierte isochinolinsulfonyl-verbindungen. |
| AU728395B2 (en) | 1996-07-19 | 2001-01-11 | Gunnar Aberg | S(-)-tolterodine in the treatment of urinary and gastrointestinal disorders |
| JP2001508302A (ja) * | 1997-01-10 | 2001-06-26 | ライフ テクノロジーズ,インコーポレイテッド | 胚性幹細胞血清置換 |
| HK1042656A1 (en) | 1999-03-25 | 2002-08-23 | 三菱制药株式会社 | Preventives/remedies for interstitial pneumonia and pulmonary fibrosis |
| AU5250400A (en) | 1999-06-18 | 2001-01-09 | Mitsubishi Pharma Corporation | Osteogenesis promoters |
| EP1367899A4 (en) * | 2001-02-14 | 2004-07-28 | Leo T Furcht | TOTIPOTENT ADULT STEM CELLS, SOURCES OF SUCH CELLS, METHODS FOR OBTAINING AND MAINTAINING SAME, METHODS FOR DIFFERENTIATING THESE CELLS, METHODS OF USING SAME, AND CELLS DERIVED FROM THE ABOVE-MENTIONED CELLS |
| CN1630716A (zh) * | 2001-12-07 | 2005-06-22 | 杰龙公司 | 人胚胎干细胞衍生的造血细胞 |
| ATE464373T1 (de) * | 2001-12-21 | 2010-04-15 | Mount Sinai Hospital Corp | Zelluläre zusammensetzungen und verfahren zur deren bereitung und verwendung |
| ATE381557T1 (de) | 2002-01-23 | 2008-01-15 | Bayer Pharmaceuticals Corp | Rho-kinase inhibitoren |
| US6664266B2 (en) | 2002-03-14 | 2003-12-16 | Children's Medical Center Corporation | Axon regeneration with PKC inhibitiors |
| GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| CA2482598C (en) * | 2002-04-22 | 2012-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase c |
| US7723106B2 (en) * | 2004-07-29 | 2010-05-25 | Food Industry Research & Development Institute | Stroma-free, serum-free, and chemically defined medium and method for ex vivo mononuclear cell expansion using the same |
| BRPI0508594A (pt) | 2004-03-08 | 2007-08-21 | Wyeth Corp | moduladores de canal de ìon |
| US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| WO2006029197A1 (en) * | 2004-09-08 | 2006-03-16 | Wisconsin Alumni Research Foundation | Medium and culture of embryonic stem cells |
| US20070077654A1 (en) * | 2004-11-01 | 2007-04-05 | Thomson James A | Platelets from stem cells |
| MX2007005200A (es) | 2004-11-01 | 2007-05-11 | Wisconsin Alumni Res Found | Plaquetas a partir de celulas germinales. |
| JP4964121B2 (ja) | 2005-02-23 | 2012-06-27 | 財団法人先端医療振興財団 | 血管内皮前駆細胞の生体外増幅方法 |
| AU2006318327B2 (en) * | 2005-11-28 | 2011-08-18 | Choongwae Pharma Corporation | Serum-free expansion of cells in culture |
| JP2008099662A (ja) * | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| US20110151554A1 (en) * | 2006-11-09 | 2011-06-23 | Akira Yuo | Method for culturing and subculturing primate embryonic stem cell, as well as method for inducing differentiation thereof |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| AU2009228215B2 (en) * | 2008-03-27 | 2015-12-10 | Asterias Biotherapeutics, Inc. | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
| JP5632831B2 (ja) * | 2008-05-02 | 2014-11-26 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 幹細胞からの肥満細胞の生産のための方法 |
| US20110263016A1 (en) * | 2008-09-25 | 2011-10-27 | Rancourt Derrick E | Expansion of Embryonic Stem Cells |
-
2010
- 2010-03-01 KR KR1020117022315A patent/KR101720961B1/ko active Active
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- 2010-03-01 CA CA2753679A patent/CA2753679C/en active Active
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- 2013-02-01 US US13/757,263 patent/US10100282B2/en active Active
-
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- 2015-08-10 JP JP2015158092A patent/JP2015192681A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| Park, C. et al., DEVELOPMENT, June 2004, 131(11):2749-2762 |
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