KR101700722B1 - 응고 인자 viii을 정제하는 방법 - Google Patents

응고 인자 viii을 정제하는 방법 Download PDF

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KR101700722B1
KR101700722B1 KR1020107028866A KR20107028866A KR101700722B1 KR 101700722 B1 KR101700722 B1 KR 101700722B1 KR 1020107028866 A KR1020107028866 A KR 1020107028866A KR 20107028866 A KR20107028866 A KR 20107028866A KR 101700722 B1 KR101700722 B1 KR 101700722B1
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fviii
resin
chromatography
buffer
column
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KR20110038634A (ko
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카린 보르그발
울리카 에릭손
구스타브 길리암
매츠 예른베르그
스테판 빙게
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옥타파마 아게
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847Multimodal interactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/647Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
KR1020107028866A 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법 Active KR101700722B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12940208P 2008-06-24 2008-06-24
EP08158893.1 2008-06-24
EP08158893 2008-06-24
US61/129,402 2008-06-24
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167023450A Division KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법

Publications (2)

Publication Number Publication Date
KR20110038634A KR20110038634A (ko) 2011-04-14
KR101700722B1 true KR101700722B1 (ko) 2017-01-31

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Application Number Title Priority Date Filing Date
KR1020107028866A Active KR101700722B1 (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법
KR1020167023450A Abandoned KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법
KR1020177024076A Active KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법

Family Applications After (2)

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KR1020167023450A Abandoned KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법
KR1020177024076A Active KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법

Country Status (19)

Country Link
US (1) US8329871B2 (enExample)
EP (2) EP2300497B1 (enExample)
JP (1) JP5619738B2 (enExample)
KR (3) KR101700722B1 (enExample)
CN (1) CN102066417B (enExample)
AU (1) AU2009264282B2 (enExample)
BR (1) BRPI0914695B1 (enExample)
CA (1) CA2728047C (enExample)
DK (2) DK2537862T3 (enExample)
ES (2) ES2538706T3 (enExample)
IL (3) IL229583B (enExample)
MX (1) MX2010013908A (enExample)
PL (1) PL2300497T3 (enExample)
PT (1) PT2300497E (enExample)
RU (2) RU2698392C2 (enExample)
SI (1) SI2300497T1 (enExample)
UA (1) UA100901C2 (enExample)
WO (1) WO2009156430A1 (enExample)
ZA (1) ZA201009162B (enExample)

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CN102066417A (zh) 2011-05-18
MX2010013908A (es) 2011-01-21
DK2537862T3 (en) 2015-06-15
WO2009156430A1 (en) 2009-12-30
EP2537862B1 (en) 2015-03-18
KR20160104740A (ko) 2016-09-05
EP2537862A1 (en) 2012-12-26
RU2015141849A (ru) 2018-12-28
DK2300497T3 (da) 2012-10-29
IL229583A0 (en) 2014-01-30
JP2011525523A (ja) 2011-09-22
IL209758A0 (en) 2011-02-28
JP5619738B2 (ja) 2014-11-05
CN102066417B (zh) 2015-11-25
KR20170102065A (ko) 2017-09-06
BRPI0914695A2 (pt) 2015-10-20
CA2728047A1 (en) 2009-12-30
AU2009264282B2 (en) 2013-04-18
UA100901C2 (ru) 2013-02-11
RU2011102437A (ru) 2012-07-27
US20110160435A1 (en) 2011-06-30
IL229583B (en) 2018-03-29
AU2009264282A1 (en) 2009-12-30
IL209758A (en) 2014-02-27
PT2300497E (pt) 2012-10-30
BRPI0914695B1 (pt) 2022-04-19
US8329871B2 (en) 2012-12-11
RU2567811C2 (ru) 2015-11-10
EP2300497A1 (en) 2011-03-30
EP2300497B1 (en) 2012-08-08
ES2391613T3 (es) 2012-11-28
KR101804136B1 (ko) 2017-12-04
RU2698392C2 (ru) 2019-08-26
KR20110038634A (ko) 2011-04-14
PL2300497T3 (pl) 2013-02-28
RU2015141849A3 (enExample) 2018-12-28
CA2728047C (en) 2019-07-30
ES2538706T3 (es) 2015-06-23
ZA201009162B (en) 2011-10-26
SI2300497T1 (sl) 2013-02-28

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