PT2300497E - Processo de purificação do factor viii de coagulação - Google Patents
Processo de purificação do factor viii de coagulação Download PDFInfo
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- PT2300497E PT2300497E PT09769279T PT09769279T PT2300497E PT 2300497 E PT2300497 E PT 2300497E PT 09769279 T PT09769279 T PT 09769279T PT 09769279 T PT09769279 T PT 09769279T PT 2300497 E PT2300497 E PT 2300497E
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- fviii
- resin
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- buffer
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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Landscapes
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| EP2027875A1 (en) * | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
| JP2012500250A (ja) | 2008-08-21 | 2012-01-05 | オクタファルマ アクチェン ゲゼルシャフト | 組換えにより産生したヒト第ｖｉｉｉ及び第ｉｘ因子 |
| CN107050437A (zh) * | 2008-09-03 | 2017-08-18 | 奥克塔法马股份有限公司 | 重组制备的因子viii的新型保护组合物 |
| US20110166332A1 (en) * | 2008-09-12 | 2011-07-07 | Ge Healthcare Bio-Sciences Ab | Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions |
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| CN103003422B (zh) | 2010-04-20 | 2015-02-11 | 奥克塔法马股份有限公司 | 用于药物蛋白的新型稳定剂 |
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| MX342235B (es) * | 2010-11-05 | 2016-09-21 | Hoffmann La Roche | Metodo optimizado para captura de anticuerpo por cromatografia de modo mixto. |
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| EP2722675B1 (en) | 2011-06-17 | 2017-01-11 | School Juridical Person Higashi-Nippon-Gakuen | Method of measuring blood coagulation time to detect lupus anticoagulants |
| US20130109807A1 (en) * | 2011-10-26 | 2013-05-02 | Bio-Rad Laboratories, Inc. | Removal of virucidal agents in mixed mode chromatography |
| CN104884147A (zh) * | 2012-10-24 | 2015-09-02 | 建新公司 | 使用mes和mops作为流动相改性剂从多峰树脂洗脱生物分子 |
| US20140154233A1 (en) | 2012-12-05 | 2014-06-05 | Csl Limited | Method of purifying therapeutic proteins |
| US10188965B2 (en) | 2012-12-05 | 2019-01-29 | Csl Behring Gmbh | Hydrophobic charge induction chromatographic depletion of a protein from a solution |
| CN103880947B (zh) * | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| CN118388581A (zh) | 2013-03-08 | 2024-07-26 | 建新公司 | 治疗性蛋白药物物质的整合连续制造 |
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| CN105324166B (zh) | 2013-07-12 | 2018-01-19 | 默克专利股份有限公司 | 利用活性炭从包含靶蛋白的样品去除片段 |
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| SG11201601221XA (en) | 2013-09-24 | 2016-04-28 | Pfizer | Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins |
| TWI671312B (zh) * | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
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| EP3102589A1 (en) * | 2014-02-04 | 2016-12-14 | Biogen MA Inc. | Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications |
| CN104861060A (zh) * | 2014-02-21 | 2015-08-26 | 神州细胞工程有限公司 | 一种纯化凝血因子viii的方法 |
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