KR101658245B1 - 개선된 세포 분석용 방법 및 장치 - Google Patents

개선된 세포 분석용 방법 및 장치 Download PDF

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Publication number
KR101658245B1
KR101658245B1 KR1020107011082A KR20107011082A KR101658245B1 KR 101658245 B1 KR101658245 B1 KR 101658245B1 KR 1020107011082 A KR1020107011082 A KR 1020107011082A KR 20107011082 A KR20107011082 A KR 20107011082A KR 101658245 B1 KR101658245 B1 KR 101658245B1
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cells
cell
cartridge
sample
analysis
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Korean (ko)
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KR20100115341A (ko
Inventor
더글라스 피. 클라크
아담 스카요위츠
캐슬린 엠. 머피
스콧 엘. 다이아몬드
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바이오마커 스트레터지스 엘엘씨
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429Signal processing
    • G01N15/1433Signal processing using image recognition
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/42Integrated assemblies, e.g. cassettes or cartridges
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/12Well or multiwell plates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/04Seals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1032Dilution or aliquotting

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
KR1020107011082A 2007-10-24 2008-10-24 개선된 세포 분석용 방법 및 장치 Expired - Fee Related KR101658245B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98227907P 2007-10-24 2007-10-24
US60/982,279 2007-10-24
US9905908P 2008-09-22 2008-09-22
US61/099,059 2008-09-22
PCT/US2008/012148 WO2009055052A2 (en) 2007-10-24 2008-10-24 Improved methods and devices for cellular analysis

Publications (2)

Publication Number Publication Date
KR20100115341A KR20100115341A (ko) 2010-10-27
KR101658245B1 true KR101658245B1 (ko) 2016-09-22

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KR1020107011082A Expired - Fee Related KR101658245B1 (ko) 2007-10-24 2008-10-24 개선된 세포 분석용 방법 및 장치

Country Status (9)

Country Link
US (2) US9121801B2 (https=)
EP (2) EP2210080B1 (https=)
JP (3) JP2011501190A (https=)
KR (1) KR101658245B1 (https=)
AU (1) AU2008317329B2 (https=)
CA (2) CA2971968C (https=)
ES (1) ES2535631T3 (https=)
PL (1) PL2210080T3 (https=)
WO (1) WO2009055052A2 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007224386B2 (en) 2006-03-06 2013-12-19 Zetiq Technologies Ltd. Methods and compositions for identifying a cell phenotype
NZ573187A (en) * 2006-06-02 2011-11-25 Pfizer Prod Inc Circulating tumor cell assay for predicting efficacy of 1gf-1r antagonist therapy
CA3138078C (en) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
US20090226059A1 (en) * 2008-02-12 2009-09-10 Richard Levenson Tissue Processing And Assessment
WO2010134073A1 (en) 2009-05-19 2010-11-25 Zetiq Technologies Ltd. Kits for and methods of differential staining of cervical cancer cells and/or tissues
EP2453005B1 (en) * 2009-07-08 2019-09-04 Nikon Corporation Cell picking-assisting device
CN102947706B (zh) 2010-04-19 2018-04-13 生物标志物策略公司 预测药物敏感性、抗性和疾病进展的组合物和方法
US9228785B2 (en) 2010-05-04 2016-01-05 Alexander Poltorak Fractal heat transfer device
JP5629939B2 (ja) * 2010-09-09 2014-11-26 株式会社パソロジー研究所 パイルアップ組織アレイ
MX349288B (es) 2011-01-21 2017-07-21 Theranos Inc Sistemas y metodos para maximizacion de uso de muestras.
CN103998394B (zh) 2011-08-01 2016-08-17 德诺弗科学公司 细胞捕获系统和使用方法
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
JP2013185920A (ja) * 2012-03-07 2013-09-19 Pathology Institute 組織アレイシートの製造方法およびその製造装置
WO2013142393A1 (en) * 2012-03-19 2013-09-26 Hudson River Biolabs Method and apparatus for collecting, transporting and maintaining live tumor specimens ex vivo
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
FR3009622B1 (fr) * 2013-08-09 2015-08-07 Novacyt Procede et dispositif de lavage d'un dispositif de pipetage-distribution
JP2017527288A (ja) 2014-09-04 2017-09-21 セラノス, インコーポレイテッドTheranos, Inc. 病原体及び抗菌薬耐性試験
KR102328995B1 (ko) * 2014-11-26 2021-11-23 나노리소스 주식회사 폭발형 나노다이아몬드의 분리 방법
US10852291B2 (en) 2015-02-03 2020-12-01 University Of Washington Fluidic device and methods of use for processing tissue for pathology
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
WO2017079674A1 (en) * 2015-11-04 2017-05-11 Northeastern University Systems for producing cellular immunotherapeutics and methods of use thereof
US10830545B2 (en) 2016-07-12 2020-11-10 Fractal Heatsink Technologies, LLC System and method for maintaining efficiency of a heat sink
US12072333B2 (en) * 2016-11-02 2024-08-27 University Of Iowa Research Foundation Method and apparatus for selective removal of cells from a cell suspension by mechanical lysis
US10391492B2 (en) 2017-08-29 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
DE102018206454A1 (de) * 2018-04-26 2019-10-31 Robert Bosch Gmbh System und Verfahren zum Einbringen von Probenmaterial
US10647954B1 (en) 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
US12560590B2 (en) * 2019-01-23 2026-02-24 Massachusetts Institute Of Technology Rapid analysis of live cells
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
AU2020267743B2 (en) 2019-05-07 2023-04-06 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
WO2020251802A1 (en) 2019-06-14 2020-12-17 Bio-Rad Laboratories, Inc. System and method for automated single cell processing and analyses
US11566217B2 (en) 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
CN114901799A (zh) 2019-10-21 2022-08-12 弗拉斯沃克斯有限责任公司 用于细胞培养的系统和方法
JP7363390B2 (ja) * 2019-11-08 2023-10-18 Jsr株式会社 細胞凝集塊分散装置および細胞凝集塊分散方法
DE112020005780T5 (de) 2019-11-27 2023-04-20 Fei Deutschland Gmbh Systeme und verfahren zur abbildung und ablation einer probe
WO2021188562A1 (en) * 2020-03-17 2021-09-23 Detect, Inc. Seal component for a rapid diagnostic test
KR102639140B1 (ko) * 2020-08-14 2024-02-20 연세대학교 산학협력단 조직 검사 방법 및 조직 검사 장치
JP2022071963A (ja) * 2020-10-29 2022-05-17 シスメックス株式会社 試料調製方法、細胞分析方法、試料調製装置および細胞分析装置
CN215727578U (zh) * 2021-05-28 2022-02-01 上海睿钰生物科技有限公司 一种计数组件及计数装置
CN118369438A (zh) 2021-12-10 2024-07-19 伯乐实验室有限公司 用形态可调节功能化颗粒进行样品处理的组合物、方法和系统
KR20240140095A (ko) * 2022-01-14 2024-09-24 디풀 다이어그노스틱스 에스.엘. 병원체 식별을 위한 시스템들, 방법들, 및 디바이스들
CN114518425B (zh) * 2022-02-11 2023-03-10 中国科学技术大学 同时检测单个免疫细胞胞浆和细胞膜的代谢物的分析方法
KR20230121326A (ko) 2022-02-11 2023-08-18 연세대학교 산학협력단 세포 검사 방법 및 장치
US20230365911A1 (en) * 2022-04-25 2023-11-16 Multiply Labs Inc. System, method, and apparatus for manufacture of engineered cells
WO2025171036A1 (en) * 2024-02-06 2025-08-14 Effani Agriculture, Inc. Automation of biopsy analysis systems and methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014097A1 (en) * 2002-05-06 2004-01-22 Mcglennen Ronald C. Genetic test apparatus and method
JP2005512023A (ja) 2001-09-21 2005-04-28 アクセス ジェネティックス エルエルシー 遠隔遺伝子分析及び診察用のシステム、方法及びキット
US20050233309A1 (en) * 2004-04-19 2005-10-20 Hankins William D Kinetic process for the detection, diagnosis, processing, and monitoring of clonal cell populations

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941317A (en) * 1973-10-26 1976-03-02 Lnih, Inc. Method and apparatus for tissue disaggregation
US4350768A (en) * 1980-09-19 1982-09-21 Bristol Myers Company Method for preparing single cell suspension
JPS63502929A (ja) * 1986-03-20 1988-10-27 ベックマン インスツルメンツ インコーポレーテッド モジュール式貯蔵機構
SE9201636L (sv) 1992-05-27 1993-11-26 Gambro Ab Sätt att utföra respektive system för cytotoxicitetstest samt kit ingående i detta system
US5356814A (en) 1992-09-29 1994-10-18 Hoffmann-La Roche Inc. Disaggregation device for cytological specimens
JPH0751559A (ja) * 1993-08-20 1995-02-28 Rigoushiya:Kk 液体試料の分配秤量装置
CA2175893C (en) * 1993-11-23 2010-06-22 Paul J. Godowski Protein tyrosine kinases named rse
US6025145A (en) * 1993-11-23 2000-02-15 Genentech, Inc. Kinase receptor activation assay
JP3329093B2 (ja) * 1994-09-22 2002-09-30 スズキ株式会社 酵素免疫反応測定装置
EP2275821A1 (en) * 1995-07-31 2011-01-19 Precision System Science Co., Ltd Container
JP3923968B2 (ja) * 1995-07-31 2007-06-06 プレシジョン・システム・サイエンス株式会社 容器使用方法
US5854009A (en) * 1995-09-19 1998-12-29 Immuna Care Corporation Method of detecting estrogen-sensitive pathologies
JPH09196917A (ja) * 1996-01-12 1997-07-31 Suzuki Motor Corp テストプレート用自動判定装置
JPH1062436A (ja) * 1996-08-21 1998-03-06 Fujirebio Inc 液体の分注方法とその装置
US6077684A (en) * 1996-11-14 2000-06-20 Vanderbilt University Automated assay for measuring apoptosis in cell culture
JP2003144149A (ja) * 1997-03-31 2003-05-20 Takara Holdings Inc 分離装置及びその使用方法
DE19729028C1 (de) * 1997-07-08 1999-05-06 Fraunhofer Ges Forschung Vorrichtung sowie Verfahren zur Isolierung von Zellmaterial aus einem Gewebeverband und/oder einer Flüssigkeit
DE19804372A1 (de) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
JP3142521B2 (ja) * 1998-11-04 2001-03-07 大成プラス株式会社 針刺し止栓とその製造方法
JP2001000178A (ja) * 1999-06-23 2001-01-09 Asahi Medical Co Ltd 細胞分離方法及び細胞分離装置
ATE335196T1 (de) * 2000-03-08 2006-08-15 Cytyc Corp Verfahren und vorrichtung zur vorbereitung von zellproben
HRP20031022A2 (en) * 2001-05-09 2005-10-31 Axis Shield Asa Assay system
US7133543B2 (en) * 2001-06-12 2006-11-07 Applied Imaging Corporation Automated scanning method for pathology samples
JP2003294765A (ja) * 2002-03-29 2003-10-15 Nippon Soda Co Ltd セプタム装着治具
US20040157336A1 (en) * 2002-11-14 2004-08-12 Affymetrix, Inc. Automated fluid control system and process
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
CA2512956A1 (en) * 2003-01-13 2004-07-29 Emory University Methods of detecting gene expression in normal and cancerous cells
JP5795699B2 (ja) * 2004-04-28 2015-10-14 サノフィ パスツール ヴァックスデザイン コーポレーション 人工免疫システム:作製および使用方法
MX2007001469A (es) * 2004-08-06 2007-03-26 Genentech Inc Ensayos y metodos que utilizan biomarcadores.
JP4686682B2 (ja) * 2004-12-02 2011-05-25 国立大学法人名古屋大学 リガンド親和性複合タンパク質の取得方法、抗体スクリーニング方法、抗体スクリーニング用キット、医療方法、抗体医薬、非免疫反応性抗体医薬、投薬方法
US20060183223A1 (en) * 2005-01-21 2006-08-17 King Michael R Continuous flow chamber device for separation, concentration, and/or purification of cells
GB0505379D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Cellular entity maturation and transportation systems
US20070031283A1 (en) * 2005-06-23 2007-02-08 Davis Charles Q Assay cartridges and methods for point of care instruments
NZ569791A (en) 2005-12-16 2011-10-28 Larry Mark Weisenthal Microaggregates including endothelial cells for microscopic observation
JP2008039551A (ja) * 2006-08-04 2008-02-21 Hitachi High-Technologies Corp 検体処理システム

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005512023A (ja) 2001-09-21 2005-04-28 アクセス ジェネティックス エルエルシー 遠隔遺伝子分析及び診察用のシステム、方法及びキット
US20040014097A1 (en) * 2002-05-06 2004-01-22 Mcglennen Ronald C. Genetic test apparatus and method
US20050233309A1 (en) * 2004-04-19 2005-10-20 Hankins William D Kinetic process for the detection, diagnosis, processing, and monitoring of clonal cell populations

Also Published As

Publication number Publication date
JP6177841B2 (ja) 2017-08-09
JP2016001184A (ja) 2016-01-07
CA2703631A1 (en) 2009-04-30
JP2018004651A (ja) 2018-01-11
JP2011501190A (ja) 2011-01-06
AU2008317329B2 (en) 2014-10-02
US20090162853A1 (en) 2009-06-25
EP2210080B1 (en) 2015-01-28
PL2210080T3 (pl) 2015-06-30
ES2535631T3 (es) 2015-05-13
EP2210080A2 (en) 2010-07-28
CA2703631C (en) 2017-08-22
WO2009055052A3 (en) 2009-07-02
CA2971968C (en) 2019-08-13
JP6675355B2 (ja) 2020-04-01
KR20100115341A (ko) 2010-10-27
US20150353880A1 (en) 2015-12-10
US9121801B2 (en) 2015-09-01
CA2971968A1 (en) 2009-04-30
WO2009055052A2 (en) 2009-04-30
EP2573541A1 (en) 2013-03-27
HK1145878A1 (en) 2011-05-06
AU2008317329A1 (en) 2009-04-30

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