KR101639456B1 - 포사코나졸의 결정질 형태 - Google Patents
포사코나졸의 결정질 형태 Download PDFInfo
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- KR101639456B1 KR101639456B1 KR1020107028674A KR20107028674A KR101639456B1 KR 101639456 B1 KR101639456 B1 KR 101639456B1 KR 1020107028674 A KR1020107028674 A KR 1020107028674A KR 20107028674 A KR20107028674 A KR 20107028674A KR 101639456 B1 KR101639456 B1 KR 101639456B1
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- Prior art keywords
- posaconazole
- crystalline form
- water
- crystalline
- rti
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13385208P | 2008-07-03 | 2008-07-03 | |
| EP08159600A EP2141159A1 (en) | 2008-07-03 | 2008-07-03 | A Crystalline form of posaconazole |
| US61/133,852 | 2008-07-03 | ||
| EP08159600.9 | 2008-07-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110025763A KR20110025763A (ko) | 2011-03-11 |
| KR101639456B1 true KR101639456B1 (ko) | 2016-07-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107028674A KR101639456B1 (ko) | 2008-07-03 | 2009-06-25 | 포사코나졸의 결정질 형태 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8435998B2 (xx) |
| EP (2) | EP2141159A1 (xx) |
| KR (1) | KR101639456B1 (xx) |
| CN (1) | CN102066363B (xx) |
| AU (1) | AU2009265848B2 (xx) |
| BR (1) | BRPI0915714A2 (xx) |
| CA (1) | CA2728170C (xx) |
| DK (1) | DK2318396T5 (xx) |
| ES (1) | ES2397592T3 (xx) |
| HR (1) | HRP20130026T2 (xx) |
| IL (1) | IL209196A (xx) |
| MX (1) | MX2010014041A (xx) |
| PL (1) | PL2318396T3 (xx) |
| RS (1) | RS52673B (xx) |
| SI (1) | SI2318396T1 (xx) |
| WO (1) | WO2010000668A1 (xx) |
| ZA (1) | ZA201008019B (xx) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2130540A1 (en) | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| CA2767489A1 (en) * | 2009-07-09 | 2011-01-13 | Sandoz Ag | A crystalline form of posaconazole |
| WO2011144653A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Process for the preparation of chiral triazolones |
| US9073904B2 (en) | 2010-05-19 | 2015-07-07 | Sandoz Ag | Preparation of posaconazole intermediates |
| MX2012013331A (es) | 2010-05-19 | 2013-02-01 | Sandoz Ag | Purificacion de posaconazol y de intermediarios de posaconazol. |
| CN102892750B (zh) * | 2010-05-19 | 2016-03-02 | 桑多斯股份公司 | 制备手性酰肼的方法 |
| CN108329303A (zh) | 2011-06-16 | 2018-07-27 | 桑多斯股份公司 | 制备手性化合物的方法 |
| US20150164890A1 (en) * | 2012-06-14 | 2015-06-18 | Sandoz Ag | Pharmaceutical compositions comprising crystalline posaconazole |
| CN105579448B (zh) * | 2013-07-25 | 2018-12-21 | 桑多斯股份公司 | 制备泊沙康唑的晶型iv的改进方法 |
| ITMI20132118A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132114A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132115A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132117A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| DE102014203040A1 (de) | 2014-02-19 | 2015-08-20 | Carl Zeiss Smt Gmbh | Beleuchtungssystem einer mikrolithographischen Projektionsbelichtungsanlage und Verfahren zum Betreiben eines solchen |
| CN104370894A (zh) * | 2014-10-21 | 2015-02-25 | 江苏恒盛药业有限公司 | 无定型泊沙康唑的制备工艺 |
| CN105622590B (zh) * | 2014-10-30 | 2019-08-20 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑的晶型vi及其制备方法 |
| PL3331501T3 (pl) | 2015-08-08 | 2020-03-31 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Preparat o zwiększonej odporności na warunki przewodu pokarmowego zawierający pozakonazol |
| EP3210599B1 (en) | 2016-02-26 | 2024-08-28 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor |
| WO2017032908A1 (en) | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
| WO2018096497A1 (en) * | 2016-11-28 | 2018-05-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of fungal infections |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| CN106883221A (zh) * | 2017-04-17 | 2017-06-23 | 兰州大学 | 一种无定形泊沙康唑及其制备方法 |
| CN107625729A (zh) * | 2017-09-29 | 2018-01-26 | 重庆华邦制药有限公司 | 泊沙康唑口服混悬液及其制备方法 |
| EP4003354A4 (en) * | 2019-07-31 | 2023-11-15 | The Regents Of The University Of Michigan | POSACONAZOLE COCRYSTALS, METHODS OF MANUFACTURE AND USE THEREOF |
| GB201917867D0 (en) * | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| EP4196096A1 (en) | 2020-08-13 | 2023-06-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant high-strength formulation containing posaconazole |
| EP4091604B1 (en) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
| EP4181883A1 (en) | 2021-11-25 | 2023-05-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713481B1 (en) | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
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| US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| DE3544983A1 (de) | 1985-12-19 | 1987-06-25 | Hoechst Ag | Antimykotisch wirksamer nagellack |
| ATE204875T1 (de) | 1993-12-21 | 2001-09-15 | Schering Corp | Fungizide tetrahydrofurane |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| MX9701229A (es) | 1995-06-02 | 1997-05-31 | Schering Corp | Antifungicos de tetrahidrofurano. |
| US5834472A (en) | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5972381A (en) | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| CZ299835B6 (cs) | 1997-10-07 | 2008-12-10 | Schering Corporation | Krystalová modifikace triazolem substituované piperazinové slouceniny s protiplísnovým úcinkem, farmaceutický prostredek ji obsahující a její použití |
| EP2090165A3 (en) | 2001-04-03 | 2012-03-28 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| US20060009469A1 (en) | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| AU2005249502A1 (en) | 2004-05-28 | 2005-12-15 | Schering Corporation | Particulate-stabilized injectable pharmaceutical compositions of posaconazole |
| WO2006000020A1 (en) | 2004-06-29 | 2006-01-05 | European Nickel Plc | Improved leaching of base metals |
| CA2613122C (en) | 2005-06-29 | 2013-01-22 | Compumedics Limited | Sensor assembly with conductive bridge |
| MX2008015275A (es) | 2006-05-30 | 2009-02-06 | Elan Pharma Int Ltd | Formulaciones de posaconazol en nanoparticulas. |
| EP2130540A1 (en) * | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| WO2011000020A1 (en) | 2009-06-12 | 2011-01-06 | Sbc Research Pty Ltd | Enhanced method of detection |
| CA2767489A1 (en) | 2009-07-09 | 2011-01-13 | Sandoz Ag | A crystalline form of posaconazole |
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2008
- 2008-07-03 EP EP08159600A patent/EP2141159A1/en not_active Withdrawn
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2009
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- 2009-06-25 BR BRPI0915714A patent/BRPI0915714A2/pt not_active Application Discontinuation
- 2009-06-25 SI SI200930468T patent/SI2318396T1/sl unknown
- 2009-06-25 MX MX2010014041A patent/MX2010014041A/es active IP Right Grant
- 2009-06-25 CN CN200980123512.4A patent/CN102066363B/zh not_active Expired - Fee Related
- 2009-06-25 WO PCT/EP2009/057975 patent/WO2010000668A1/en active Application Filing
- 2009-06-25 AU AU2009265848A patent/AU2009265848B2/en not_active Ceased
- 2009-06-25 DK DK09772368.8T patent/DK2318396T5/da active
- 2009-06-25 KR KR1020107028674A patent/KR101639456B1/ko active IP Right Grant
- 2009-06-25 RS RS20130006A patent/RS52673B/en unknown
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- 2010-11-09 ZA ZA2010/08019A patent/ZA201008019B/en unknown
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2013
- 2013-01-15 HR HRP20130026AT patent/HRP20130026T2/hr unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713481B1 (en) | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
Also Published As
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| ES2397592T3 (es) | 2013-03-08 |
| CA2728170A1 (en) | 2010-01-07 |
| CN102066363A (zh) | 2011-05-18 |
| KR20110025763A (ko) | 2011-03-11 |
| RS52673B (en) | 2013-06-28 |
| WO2010000668A1 (en) | 2010-01-07 |
| EP2318396B1 (en) | 2012-10-24 |
| EP2141159A1 (en) | 2010-01-06 |
| SI2318396T1 (sl) | 2013-02-28 |
| ZA201008019B (en) | 2012-02-29 |
| AU2009265848A1 (en) | 2010-01-07 |
| DK2318396T3 (da) | 2013-02-04 |
| HRP20130026T1 (hr) | 2013-02-28 |
| IL209196A0 (en) | 2011-01-31 |
| HRP20130026T2 (xx) | 2013-10-11 |
| EP2318396A1 (en) | 2011-05-11 |
| IL209196A (en) | 2015-08-31 |
| MX2010014041A (es) | 2011-03-03 |
| CN102066363B (zh) | 2014-11-05 |
| BRPI0915714A2 (pt) | 2015-10-27 |
| CA2728170C (en) | 2017-02-14 |
| AU2009265848B2 (en) | 2014-02-20 |
| PL2318396T3 (pl) | 2013-03-29 |
| DK2318396T5 (da) | 2013-09-02 |
| US8435998B2 (en) | 2013-05-07 |
| US20110065722A1 (en) | 2011-03-17 |
| EP2318396B9 (en) | 2013-05-29 |
| ES2397592T9 (es) | 2013-08-30 |
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