DK2318396T3 - Krystalform af posaconazol - Google Patents
Krystalform af posaconazolInfo
- Publication number
- DK2318396T3 DK2318396T3 DK09772368.8T DK09772368T DK2318396T3 DK 2318396 T3 DK2318396 T3 DK 2318396T3 DK 09772368 T DK09772368 T DK 09772368T DK 2318396 T3 DK2318396 T3 DK 2318396T3
- Authority
- DK
- Denmark
- Prior art keywords
- posaconazole
- crystal form
- crystal
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title 1
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 title 1
- 229960001589 posaconazole Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13385208P | 2008-07-03 | 2008-07-03 | |
| EP08159600A EP2141159A1 (en) | 2008-07-03 | 2008-07-03 | A Crystalline form of posaconazole |
| PCT/EP2009/057975 WO2010000668A1 (en) | 2008-07-03 | 2009-06-25 | A crystalline form of posaconazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2318396T3 true DK2318396T3 (da) | 2013-02-04 |
| DK2318396T5 DK2318396T5 (da) | 2013-09-02 |
Family
ID=39951578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09772368.8T DK2318396T5 (da) | 2008-07-03 | 2009-06-25 | Krystalform af posaconazol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8435998B2 (da) |
| EP (2) | EP2141159A1 (da) |
| KR (1) | KR101639456B1 (da) |
| CN (1) | CN102066363B (da) |
| AU (1) | AU2009265848B2 (da) |
| BR (1) | BRPI0915714A2 (da) |
| CA (1) | CA2728170C (da) |
| DK (1) | DK2318396T5 (da) |
| ES (1) | ES2397592T3 (da) |
| HR (1) | HRP20130026T2 (da) |
| IL (1) | IL209196A (da) |
| MX (1) | MX2010014041A (da) |
| PL (1) | PL2318396T3 (da) |
| RS (1) | RS52673B (da) |
| SI (1) | SI2318396T1 (da) |
| WO (1) | WO2010000668A1 (da) |
| ZA (1) | ZA201008019B (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2130540A1 (en) | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| EP2451805A1 (en) * | 2009-07-09 | 2012-05-16 | Sandoz AG | A crystalline form of posaconazole |
| EP2571847B1 (en) | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
| RU2580318C2 (ru) | 2010-05-19 | 2016-04-10 | Сандоз Аг | Получение промежуточных продуктов для синтеза позаконазола |
| WO2011144657A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Purification of posaconazole and posaconazole intermediates |
| CN102906087B (zh) * | 2010-05-19 | 2016-03-23 | 桑多斯股份公司 | 制备手性三唑酮的方法 |
| CN103635465A (zh) | 2011-06-16 | 2014-03-12 | 桑多斯股份公司 | 制备手性化合物的方法 |
| EP2861213A1 (en) * | 2012-06-14 | 2015-04-22 | Sandoz AG | Pharmaceutical composition comprising crystalline posaconazole |
| EP3024828B1 (en) * | 2013-07-25 | 2017-05-17 | Sandoz AG | Improved process for the preparation of crystalline form iv of posaconazole |
| ITMI20132118A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132114A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132115A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132117A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| DE102014203040A1 (de) | 2014-02-19 | 2015-08-20 | Carl Zeiss Smt Gmbh | Beleuchtungssystem einer mikrolithographischen Projektionsbelichtungsanlage und Verfahren zum Betreiben eines solchen |
| CN104370894A (zh) * | 2014-10-21 | 2015-02-25 | 江苏恒盛药业有限公司 | 无定型泊沙康唑的制备工艺 |
| CN105622590B (zh) * | 2014-10-30 | 2019-08-20 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑的晶型vi及其制备方法 |
| WO2017025292A1 (en) | 2015-08-08 | 2017-02-16 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant formulation containing posaconazole |
| EP3210599A1 (en) | 2016-02-26 | 2017-08-30 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor |
| WO2017032908A1 (en) | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
| JP7176760B2 (ja) * | 2016-11-28 | 2022-11-22 | セリックス バイオ プライヴェート リミテッド | 真菌感染の処置のための組成物及び方法 |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| CN106883221A (zh) * | 2017-04-17 | 2017-06-23 | 兰州大学 | 一种无定形泊沙康唑及其制备方法 |
| CN107625729A (zh) * | 2017-09-29 | 2018-01-26 | 重庆华邦制药有限公司 | 泊沙康唑口服混悬液及其制备方法 |
| US20220259189A1 (en) * | 2019-07-31 | 2022-08-18 | Regents Of The University Of Michigan | Cocrystals of posaconazole, methods of making and using same |
| GB201917867D0 (en) * | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| WO2022034232A1 (en) | 2020-08-13 | 2022-02-17 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant high-strength formulation containing posaconazole |
| EP4091604B1 (en) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
| WO2023012378A1 (en) | 2021-11-25 | 2023-02-09 | Alfred E. Tiefenbacher (Gmbh Und Co. Kg) | Granules containing posaconazole |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| DE3544983A1 (de) | 1985-12-19 | 1987-06-25 | Hoechst Ag | Antimykotisch wirksamer nagellack |
| CO4520281A1 (es) * | 1993-12-21 | 1997-10-15 | Schering Corp | Antifungicos de tetrahidrofurano |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| IL118464A (en) | 1995-06-02 | 2000-08-13 | Schering Corp | (2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them |
| US5834472A (en) | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5972381A (en) | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| AU759982B2 (en) | 1997-10-07 | 2003-05-01 | Merck Sharp & Dohme Corp. | Crystalline antifungal polymorph |
| US6713481B1 (en) | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
| BR0208626A (pt) | 2001-04-03 | 2004-03-09 | Schering Corp | Composição antifúngica com biodisponibilidade intensificada |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| US20060009469A1 (en) | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| MXPA06013886A (es) | 2004-05-28 | 2007-01-26 | Schering Corp | Suspension farmaceutica inyectable que comprende posaconazol. |
| EP1769092A4 (en) | 2004-06-29 | 2008-08-06 | Europ Nickel Plc | IMPROVED LIXIVIATION OF BASE METALS |
| WO2007000020A1 (en) | 2005-06-29 | 2007-01-04 | Compumedics Limited | Sensor assembly with conductive bridge |
| JP2009538927A (ja) | 2006-05-30 | 2009-11-12 | エラン ファーマ インターナショナル，リミティド | ナノ粒子状のポサコナゾール製剤 |
| EP2130540A1 (en) * | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| WO2011000020A1 (en) | 2009-06-12 | 2011-01-06 | Sbc Research Pty Ltd | Enhanced method of detection |
| EP2451805A1 (en) | 2009-07-09 | 2012-05-16 | Sandoz AG | A crystalline form of posaconazole |
-
2008
- 2008-07-03 EP EP08159600A patent/EP2141159A1/en not_active Withdrawn
-
2009
- 2009-06-25 BR BRPI0915714A patent/BRPI0915714A2/pt not_active Application Discontinuation
- 2009-06-25 KR KR1020107028674A patent/KR101639456B1/ko active IP Right Grant
- 2009-06-25 CA CA2728170A patent/CA2728170C/en not_active Expired - Fee Related
- 2009-06-25 WO PCT/EP2009/057975 patent/WO2010000668A1/en active Application Filing
- 2009-06-25 MX MX2010014041A patent/MX2010014041A/es active IP Right Grant
- 2009-06-25 RS RS20130006A patent/RS52673B/en unknown
- 2009-06-25 DK DK09772368.8T patent/DK2318396T5/da active
- 2009-06-25 AU AU2009265848A patent/AU2009265848B2/en not_active Ceased
- 2009-06-25 ES ES09772368T patent/ES2397592T3/es active Active
- 2009-06-25 SI SI200930468T patent/SI2318396T1/sl unknown
- 2009-06-25 US US12/993,351 patent/US8435998B2/en active Active
- 2009-06-25 CN CN200980123512.4A patent/CN102066363B/zh not_active Expired - Fee Related
- 2009-06-25 EP EP09772368.8A patent/EP2318396B9/en active Active
- 2009-06-25 PL PL09772368T patent/PL2318396T3/pl unknown
-
2010
- 2010-11-08 IL IL209196A patent/IL209196A/en active IP Right Grant
- 2010-11-09 ZA ZA2010/08019A patent/ZA201008019B/en unknown
-
2013
- 2013-01-15 HR HRP20130026AT patent/HRP20130026T2/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009265848A1 (en) | 2010-01-07 |
| BRPI0915714A2 (pt) | 2015-10-27 |
| KR101639456B1 (ko) | 2016-07-13 |
| CA2728170C (en) | 2017-02-14 |
| RS52673B (en) | 2013-06-28 |
| MX2010014041A (es) | 2011-03-03 |
| US8435998B2 (en) | 2013-05-07 |
| ES2397592T3 (es) | 2013-03-08 |
| HRP20130026T1 (hr) | 2013-02-28 |
| ES2397592T9 (es) | 2013-08-30 |
| CN102066363A (zh) | 2011-05-18 |
| WO2010000668A1 (en) | 2010-01-07 |
| EP2318396B9 (en) | 2013-05-29 |
| EP2318396B1 (en) | 2012-10-24 |
| ZA201008019B (en) | 2012-02-29 |
| SI2318396T1 (sl) | 2013-02-28 |
| AU2009265848B2 (en) | 2014-02-20 |
| DK2318396T5 (da) | 2013-09-02 |
| HRP20130026T2 (en) | 2013-10-11 |
| EP2318396A1 (en) | 2011-05-11 |
| CA2728170A1 (en) | 2010-01-07 |
| IL209196A0 (en) | 2011-01-31 |
| US20110065722A1 (en) | 2011-03-17 |
| CN102066363B (zh) | 2014-11-05 |
| EP2141159A1 (en) | 2010-01-06 |
| IL209196A (en) | 2015-08-31 |
| KR20110025763A (ko) | 2011-03-11 |
| PL2318396T3 (pl) | 2013-03-29 |
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