KR101560073B1 - 퀴놀론 화합물 - Google Patents

퀴놀론 화합물 Download PDF

Info

Publication number
KR101560073B1
KR101560073B1 KR1020137018036A KR20137018036A KR101560073B1 KR 101560073 B1 KR101560073 B1 KR 101560073B1 KR 1020137018036 A KR1020137018036 A KR 1020137018036A KR 20137018036 A KR20137018036 A KR 20137018036A KR 101560073 B1 KR101560073 B1 KR 101560073B1
Authority
KR
South Korea
Prior art keywords
alkyl
group
optionally substituted
substituted
compound
Prior art date
Application number
KR1020137018036A
Other languages
English (en)
Korean (ko)
Other versions
KR20130095831A (ko
Inventor
마무티 아부두사이미
팡구오 예
지앙퀸 순
히사시 미야모토
제이페이 쳉
다이스케 오카
Original Assignee
오쓰까 세이야꾸 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오쓰까 세이야꾸 가부시키가이샤 filed Critical 오쓰까 세이야꾸 가부시키가이샤
Publication of KR20130095831A publication Critical patent/KR20130095831A/ko
Application granted granted Critical
Publication of KR101560073B1 publication Critical patent/KR101560073B1/ko

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020137018036A 2011-08-31 2012-08-30 퀴놀론 화합물 KR101560073B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2011001477 2011-08-31
CNPCT/CN2011/001477 2011-08-31
CN2012001044 2012-08-06
CNPCT/CN2012/001044 2012-08-06
PCT/CN2012/080753 WO2013029548A1 (en) 2011-08-31 2012-08-30 Quinolone compound

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020147031410A Division KR20140139132A (ko) 2011-08-31 2012-08-30 퀴놀론 화합물
KR1020147017145A Division KR101996697B1 (ko) 2011-08-31 2012-08-30 퀴놀론 화합물

Publications (2)

Publication Number Publication Date
KR20130095831A KR20130095831A (ko) 2013-08-28
KR101560073B1 true KR101560073B1 (ko) 2015-10-13

Family

ID=47755336

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020137018036A KR101560073B1 (ko) 2011-08-31 2012-08-30 퀴놀론 화합물
KR1020147031410A KR20140139132A (ko) 2011-08-31 2012-08-30 퀴놀론 화합물
KR1020147017145A KR101996697B1 (ko) 2011-08-31 2012-08-30 퀴놀론 화합물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020147031410A KR20140139132A (ko) 2011-08-31 2012-08-30 퀴놀론 화합물
KR1020147017145A KR101996697B1 (ko) 2011-08-31 2012-08-30 퀴놀론 화합물

Country Status (29)

Country Link
US (7) US9067887B2 (US07585860-20090908-C00112.png)
EP (2) EP3318557A3 (US07585860-20090908-C00112.png)
JP (4) JP6106174B2 (US07585860-20090908-C00112.png)
KR (3) KR101560073B1 (US07585860-20090908-C00112.png)
CN (3) CN103764631B (US07585860-20090908-C00112.png)
AR (1) AR087747A1 (US07585860-20090908-C00112.png)
AU (2) AU2012303954B2 (US07585860-20090908-C00112.png)
BR (1) BR112014000665B8 (US07585860-20090908-C00112.png)
CA (1) CA2845459C (US07585860-20090908-C00112.png)
CO (1) CO6920292A2 (US07585860-20090908-C00112.png)
CY (1) CY1120066T1 (US07585860-20090908-C00112.png)
DK (1) DK2751083T3 (US07585860-20090908-C00112.png)
EA (2) EA030867B1 (US07585860-20090908-C00112.png)
ES (1) ES2660973T3 (US07585860-20090908-C00112.png)
HK (4) HK1198828A1 (US07585860-20090908-C00112.png)
HR (1) HRP20180483T1 (US07585860-20090908-C00112.png)
HU (1) HUE036301T2 (US07585860-20090908-C00112.png)
IL (1) IL230559B (US07585860-20090908-C00112.png)
LT (1) LT2751083T (US07585860-20090908-C00112.png)
MX (2) MX371361B (US07585860-20090908-C00112.png)
MY (1) MY165004A (US07585860-20090908-C00112.png)
NO (1) NO2751083T3 (US07585860-20090908-C00112.png)
PL (1) PL2751083T3 (US07585860-20090908-C00112.png)
PT (1) PT2751083T (US07585860-20090908-C00112.png)
SG (3) SG10201505811QA (US07585860-20090908-C00112.png)
SI (1) SI2751083T1 (US07585860-20090908-C00112.png)
TW (3) TWI606044B (US07585860-20090908-C00112.png)
WO (1) WO2013029548A1 (US07585860-20090908-C00112.png)
ZA (1) ZA201402326B (US07585860-20090908-C00112.png)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2845551T3 (es) * 2011-02-01 2021-07-27 Emergent Product Dev Gaithersburg Inc 4-oxoquinolizinas antimicrobianas
SG10201505811QA (en) * 2011-08-31 2015-09-29 Otsuka Pharma Co Ltd Quinolone compound
CA2903881C (en) * 2013-03-15 2021-05-18 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
ES2635560T3 (es) 2013-07-08 2017-10-04 Incyte Holdings Corporation Heterociclos tricíclicos como inhibidores de la proteína NET
CN104513253A (zh) 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
NZ763737A (en) 2014-04-23 2023-04-28 Incyte Holdings Corp 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins
US9527864B2 (en) 2014-09-15 2016-12-27 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
DK3226858T3 (da) 2014-12-04 2021-03-29 Procomcure Biotech Gmbh Imidazolbaserede antimikrobielle stoffer
US10314820B2 (en) 2014-12-04 2019-06-11 Procomcure Biotech Gmbh Imidazole-based heterocyclic compounds
KR102123365B1 (ko) * 2015-07-28 2020-06-16 바이옴 테라퓨틱스 리미티드 항박테리아 치료제 및 예방제
WO2017075377A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
US10226464B2 (en) * 2015-12-29 2019-03-12 ImmuneTarget, Inc. Small molecule NF-κB inhibitors
US10189832B2 (en) 2016-06-20 2019-01-29 Incyte Corporation Crystalline solid forms of a BET inhibitor
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
KR102537749B1 (ko) 2017-06-14 2023-05-26 산요 시키소 가부시키가이샤 안료 분산체 및 그것을 포함하는 착색 조성물
CN108191889B (zh) * 2018-01-11 2019-06-07 河南大学 1-(n-氧氟沙星酰胺基)-6-氟-7-哌嗪萘啶酮酸化合物及其制备方法和应用
CN107964020B (zh) * 2018-01-11 2019-07-05 河南大学 1-(n-左氧氟沙星酰胺基)-6-氟-7-哌嗪萘啶酮酸化合物及其制备方法和应用
JP2021534156A (ja) 2018-08-13 2021-12-09 大塚製薬株式会社 新規炎症性腸疾患治療剤
WO2020163816A1 (en) * 2019-02-08 2020-08-13 Frequency Therapeutics, Inc. Quinolin-4-one and 4(1h)-cinnolinone compounds and methods of using same
CN110563645B (zh) * 2019-06-14 2021-03-30 山东省联合农药工业有限公司 一种喹诺酮类化合物及其制备方法和应用
CN112624970B (zh) * 2019-09-24 2022-10-28 南开大学 8位芳基取代喹啉氮氧化物在抗植物病毒及杀菌方面的应用
CN113264878B (zh) * 2019-11-11 2022-05-27 山东畜牧兽医职业学院 一种用于畜牧业治疗耐药性微生物菌的化合物的制备方法
JP2023012557A (ja) 2020-02-10 2023-01-26 大塚製薬株式会社 新規肝性脳症治療剤
JP2023012559A (ja) 2020-02-10 2023-01-26 大塚製薬株式会社 新規炎症性疾患治療剤
JP2023012558A (ja) 2020-02-10 2023-01-26 大塚製薬株式会社 腸内細菌叢構成比率調整剤
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
WO2023208172A1 (en) * 2022-04-29 2023-11-02 Beigene , Ltd. Substituted 7- (pyrimidin-4-yl) quinolin-4 (1h) -one compounds as cyclin dependent kinase inhibitors
WO2024012421A1 (en) * 2022-07-11 2024-01-18 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical compositions comprising a quinolone compound for irritable bowel syndrome

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0343398A2 (de) * 1988-05-11 1989-11-29 Bayer Ag 7-Substituierte Chinolon- und Naphthyridoncarbonsäure-Derivate
KR100371723B1 (ko) 1994-08-12 2003-03-15 도야마 가가쿠 고교 가부시키가이샤 신규한퀴놀론-또는나프틸리돈-카복실산유도체또는그의염

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5781486A (en) * 1980-11-10 1982-05-21 Otsuka Pharmaceut Co Ltd Benzo(ij)quinolidine-2-carboxylic acid derivative
JPS5872589A (ja) * 1981-10-28 1983-04-30 Dai Ichi Seiyaku Co Ltd ピリド〔１，２，３−ｄｅ〕〔１，４〕ベンゾオキサジン誘導体
US4443447A (en) 1982-10-25 1984-04-17 Riker Laboratories, Inc. Phenyl-substituted tricyclic antibacterial agents
ZA859283B (en) 1984-12-06 1987-07-29 Pfizer Substituted dihydroquinolone carboxylic acids and anti-bacterial compositions containing them
US4623650A (en) * 1984-12-06 1986-11-18 Pfizer Inc. Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
US4636506A (en) * 1984-12-06 1987-01-13 Pfizer, Inc. 7-heterocyclic-1,4-dihydroquinolones
US4797490A (en) * 1984-12-06 1989-01-10 Pfizer Inc. Process for the preparation of 3-(2'-fluorophenyl)pyridine
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
IT1197841B (it) * 1986-10-14 1988-12-06 Mediolanum Farmaceutici Srl Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione
US4929613A (en) 1987-08-26 1990-05-29 Warner-Lambert Company Antibacterial agents
US5081254A (en) 1987-08-26 1992-01-14 Warner-Lambert Company Antibacterial agents
US5075319A (en) * 1987-09-08 1991-12-24 Sterling Drug Inc. Pyridinyl-quinolone compounds, their preparation and use
US4839355A (en) * 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH0366301A (ja) 1989-08-03 1991-03-22 Asahi Corp 靴底射出成形金型
KR910009333B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5308843A (en) * 1990-09-11 1994-05-03 Sterling Drug Inc. Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids
CA2099591C (en) 1990-12-05 2002-11-12 Rajeshwar Singh 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3- carboxylic acid compounds useful as antibacterial agents
EP0994878B1 (en) 1997-06-26 2001-11-28 Dong Wha Pharmaceutical Industrial Co. Ltd. Quinolone carboxylic acid derivatives
AU8128898A (en) 1997-07-16 1999-02-10 Eisai Co. Ltd. Antibiotics containing indole derivatives
JP4370002B2 (ja) * 1997-08-08 2009-11-25 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
TW593308B (en) 1997-10-27 2004-06-21 Toyama Chemical Co Ltd Processes for producing 7-isoindoline-quinolonecarboxylic acid derivative and its intermediate
DK1070713T3 (da) 1998-04-06 2006-12-27 Toyama Chemical Co Ltd Quinoloncarboxylsyrederivater eller salte deraf
JP2000229946A (ja) * 1998-12-10 2000-08-22 Toyama Chem Co Ltd キノロンカルボン酸の製造法およびその中間体
JP4621356B2 (ja) * 1999-02-05 2011-01-26 富山化学工業株式会社 三環キノロンカルボン酸誘導体またはその塩
US20020049223A1 (en) * 1999-11-05 2002-04-25 Elmore Steven W. Quinoline and naphthyridine carboxylic acid antibacterials
DE10026903A1 (de) * 2000-06-03 2002-01-10 Cpc Cellular Process Chemistry Verfahren zur Herstellung von Chinolon-3-carbonsäuren
WO2002009758A2 (en) * 2000-08-01 2002-02-07 Wockhardt Limited Inhibitors of cellular efflux pumps of microbes
JP2003104988A (ja) * 2001-09-28 2003-04-09 Sato Pharmaceutical Co Ltd 抗菌剤として有用なキノロン誘導体
US7012144B2 (en) 2001-12-31 2006-03-14 Korea Research Institute Of Chemical Technology Quinolone carboxylic acid derivatives
JP3885679B2 (ja) * 2002-06-28 2007-02-21 株式会社日立製作所 電子機器
US20070224282A1 (en) * 2005-03-28 2007-09-27 Toyama Chemical Co., Ltd. Fine Dispersion of Sparingly Soluble Drug and Process for Producing the Same
WO2007094077A1 (ja) * 2006-02-17 2007-08-23 Kyushu University 微生物検出法及び微生物検出キット
CN101168541A (zh) * 2006-10-26 2008-04-30 孙飘扬 喹诺酮羧酸类衍生物及其制备方法和药物用途
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
US20090270379A1 (en) * 2008-04-23 2009-10-29 Macielag Mark J Quinolone derivatives useful as antibacterial agents
EP2177214A1 (en) * 2008-10-17 2010-04-21 Ferrer Internacional, S.A. Solid Oral Dosage Forms and Uses
SG10201505811QA (en) * 2011-08-31 2015-09-29 Otsuka Pharma Co Ltd Quinolone compound

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0343398A2 (de) * 1988-05-11 1989-11-29 Bayer Ag 7-Substituierte Chinolon- und Naphthyridoncarbonsäure-Derivate
KR100371723B1 (ko) 1994-08-12 2003-03-15 도야마 가가쿠 고교 가부시키가이샤 신규한퀴놀론-또는나프틸리돈-카복실산유도체또는그의염

Also Published As

Publication number Publication date
SG10201505811QA (en) 2015-09-29
IL230559A0 (en) 2014-03-31
EP2751083A4 (en) 2015-06-10
CA2845459C (en) 2019-08-27
US20160340314A1 (en) 2016-11-24
HK1216528A1 (zh) 2016-11-18
US9067887B2 (en) 2015-06-30
EP2751083B1 (en) 2017-12-27
PL2751083T3 (pl) 2018-08-31
TWI583680B (zh) 2017-05-21
KR101996697B1 (ko) 2019-07-04
US20200055823A1 (en) 2020-02-20
KR20130095831A (ko) 2013-08-28
ZA201402326B (en) 2016-06-29
US20170362180A1 (en) 2017-12-21
CN105712976A (zh) 2016-06-29
BR112014000665B8 (pt) 2020-03-10
US9440951B2 (en) 2016-09-13
CY1120066T1 (el) 2018-12-12
CN103764631A (zh) 2014-04-30
AU2017203756A1 (en) 2017-06-22
AU2012303954B2 (en) 2017-06-22
JP2018150324A (ja) 2018-09-27
AR087747A1 (es) 2014-04-16
SG10201606932TA (en) 2016-10-28
JP2017039733A (ja) 2017-02-23
MY165004A (en) 2018-02-28
HK1226077A1 (zh) 2017-09-22
JP2014525420A (ja) 2014-09-29
MX2019010100A (es) 2019-10-15
WO2013029548A1 (en) 2013-03-07
EP3318557A3 (en) 2018-07-11
EA030867B1 (ru) 2018-10-31
PT2751083T (pt) 2018-03-05
EA201490530A1 (ru) 2014-06-30
HUE036301T2 (hu) 2018-06-28
US20210032207A1 (en) 2021-02-04
TW201718506A (zh) 2017-06-01
DK2751083T3 (en) 2018-02-26
JP6039025B2 (ja) 2016-12-07
TWI606044B (zh) 2017-11-21
AU2012303954A1 (en) 2014-02-20
KR20140087059A (ko) 2014-07-08
JP6106174B2 (ja) 2017-03-29
BR112014000665B1 (pt) 2020-02-18
HRP20180483T1 (hr) 2018-05-04
EP3318557A2 (en) 2018-05-09
CN103764631B (zh) 2017-02-15
TW201319053A (zh) 2013-05-16
IL230559B (en) 2019-03-31
JP2016027046A (ja) 2016-02-18
BR112014000665A2 (pt) 2017-01-10
ES2660973T3 (es) 2018-03-26
SG2014004162A (en) 2014-03-28
HK1252389A1 (zh) 2019-05-24
US20150239865A1 (en) 2015-08-27
LT2751083T (lt) 2018-03-26
CN105017151B (zh) 2019-04-02
CO6920292A2 (es) 2014-04-10
SI2751083T1 (en) 2018-04-30
KR20140139132A (ko) 2014-12-04
EP2751083A1 (en) 2014-07-09
US20140179675A1 (en) 2014-06-26
US20190077762A1 (en) 2019-03-14
CA2845459A1 (en) 2013-03-07
HK1198828A1 (en) 2015-06-12
TW201630900A (zh) 2016-09-01
EA034787B1 (ru) 2020-03-20
CN105017151A (zh) 2015-11-04
AU2017203756B2 (en) 2019-02-07
EA201890098A2 (ru) 2018-05-31
MX371361B (es) 2020-01-27
MX2014002338A (es) 2014-03-27
NO2751083T3 (US07585860-20090908-C00112.png) 2018-05-26
US20150005287A2 (en) 2015-01-01
NZ620447A (en) 2016-02-26
EA201890098A3 (ru) 2018-09-28

Similar Documents

Publication Publication Date Title
KR101560073B1 (ko) 퀴놀론 화합물
JP2742248B2 (ja) ７−（４−アミノメチル−３−オキシム）ピロリジン置換体を持つ新規なキノリンカルボン酸誘導体およびその製造方法
US7238694B2 (en) Rifamycin imino derivatives effective against drug-resistant microbes
US20040029882A1 (en) Antimicrobial quinolones, their compositions and uses
MXPA05001180A (es) Derivados aza-biciclicos antimicrobianos, sus composiciones y usos.
KR100516379B1 (ko) 신규 피리돈카르복실산 유도체 또는 그의 염 및 이를 유효 성분으로 하는 의약
AU2002230891A1 (en) Antimicrobial quinolones
JPH0813811B2 (ja) ７―（１―アセチジニル）―１、４―ジヒドロ―４―オキソキノリン―３―カルボン酸の誘導体、その製造法、およびその医薬としての用途
WO2010093341A1 (en) C-7 isoxazolinyl quinolone/naphthyridine derivatives useful as antibacterial agents
PL175870B1 (pl) Pochodne kwasu 5-amino-8-metylo-7-pirolidynylochinolino-3-karboksylowego, sposób ich wytwarzania oraz kompozycja farmaceutyczna
SU1456015A3 (ru) Способ получени производных 1,8-нафтиридина или их кислотно-аддитивных солей (его варианты)
KR900009024B1 (ko) 퀴놀론카르복실산 화합물 및 이의 약학적 용도
US7902227B2 (en) C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
KR100332527B1 (ko) 피리돈카르본산유도체또는이것의염및그제조방법
NZ620447B2 (en) Quinolone compound
CN101353348A (zh) 7-[4-(胺甲基)-4-氟-3-(烷氧亚氨基)吡咯烷-1-基]取代的喹啉羧酸衍生物及其制备方法

Legal Events

Date Code Title Description
A201 Request for examination
AMND Amendment
A302 Request for accelerated examination
E902 Notification of reason for refusal
A107 Divisional application of patent
AMND Amendment
E601 Decision to refuse application
A107 Divisional application of patent
AMND Amendment
E902 Notification of reason for refusal
AMND Amendment
X701 Decision to grant (after re-examination)
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20180918

Year of fee payment: 4