KR101529404B1 - N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 - Google Patents

N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 Download PDF

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KR101529404B1
KR101529404B1 KR1020137013652A KR20137013652A KR101529404B1 KR 101529404 B1 KR101529404 B1 KR 101529404B1 KR 1020137013652 A KR1020137013652 A KR 1020137013652A KR 20137013652 A KR20137013652 A KR 20137013652A KR 101529404 B1 KR101529404 B1 KR 101529404B1
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KR20140014078A (ko
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스코트 윌리암 베이글리
로버트 리 도우
데이비드 앤드류 그리피스
아론 크리스토퍼 스미스
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화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020137013652A 2010-10-29 2011-10-18 N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 Expired - Fee Related KR101529404B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40812710P 2010-10-29 2010-10-29
US61/408,127 2010-10-29
US201161531744P 2011-09-07 2011-09-07
US61/531,744 2011-09-07
PCT/IB2011/054643 WO2012056372A1 (en) 2010-10-29 2011-10-18 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS

Related Child Applications (1)

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KR20147036653A Division KR20150006899A (ko) 2010-10-29 2011-10-18 N1/N2-락탐 아세틸-CoA 카복실라아제 억제제

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KR20140014078A KR20140014078A (ko) 2014-02-05
KR101529404B1 true KR101529404B1 (ko) 2015-06-26

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KR20147036653A Withdrawn KR20150006899A (ko) 2010-10-29 2011-10-18 N1/N2-락탐 아세틸-CoA 카복실라아제 억제제

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US (3) US8859773B2 (enExample)
EP (2) EP2632925B1 (enExample)
JP (2) JP5647356B2 (enExample)
KR (2) KR101529404B1 (enExample)
CN (2) CN103189377B (enExample)
AR (1) AR083578A1 (enExample)
AU (1) AU2011322117B2 (enExample)
BR (1) BR112013010310A2 (enExample)
CA (1) CA2815169C (enExample)
CY (1) CY1116405T1 (enExample)
DK (1) DK2632925T3 (enExample)
ES (1) ES2546465T3 (enExample)
HK (1) HK1209733A1 (enExample)
HU (1) HUE025078T2 (enExample)
IL (1) IL225779A0 (enExample)
MX (1) MX2013004733A (enExample)
NZ (1) NZ609527A (enExample)
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PT (1) PT2632925E (enExample)
RU (1) RU2540337C2 (enExample)
SG (1) SG189883A1 (enExample)
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TW (3) TWI507406B (enExample)
UY (1) UY33694A (enExample)
WO (1) WO2012056372A1 (enExample)
ZA (1) ZA201303882B (enExample)

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MX2013004733A (es) 2013-07-02
CA2815169A1 (en) 2012-05-03
EP2952514A1 (en) 2015-12-09
US20150025098A1 (en) 2015-01-22
IL225779A0 (en) 2013-06-27
EP2632925B1 (en) 2015-05-27
EP2632925A1 (en) 2013-09-04
TW201531472A (zh) 2015-08-16
SI2632925T1 (sl) 2015-07-31
WO2012056372A1 (en) 2012-05-03
KR20150006899A (ko) 2015-01-19
AR083578A1 (es) 2013-03-06
ES2546465T3 (es) 2015-09-23
DK2632925T3 (en) 2015-06-29
BR112013010310A2 (pt) 2016-11-29
ZA201303882B (en) 2014-02-26
US20120108619A1 (en) 2012-05-03
JP5647356B2 (ja) 2014-12-24
US9181252B2 (en) 2015-11-10
CA2815169C (en) 2015-10-06
US20150152109A1 (en) 2015-06-04
AU2011322117B2 (en) 2015-01-22
US8859773B2 (en) 2014-10-14
US8993586B2 (en) 2015-03-31
JP2013542218A (ja) 2013-11-21
SG189883A1 (en) 2013-06-28
TWI441823B (zh) 2014-06-21
TWI507406B (zh) 2015-11-11
CN104774205A (zh) 2015-07-15
HUE025078T2 (en) 2016-01-28
PL2632925T3 (pl) 2015-10-30
HK1209733A1 (en) 2016-04-08
CY1116405T1 (el) 2017-02-08
AU2011322117A1 (en) 2013-05-02
TW201418256A (zh) 2014-05-16
RU2540337C2 (ru) 2015-02-10
PT2632925E (pt) 2015-09-01
JP2015057416A (ja) 2015-03-26
HK1186724A1 (en) 2014-03-21
CN103189377A (zh) 2013-07-03
NZ609527A (en) 2014-03-28
TW201302751A (zh) 2013-01-16
RU2013116924A (ru) 2014-12-10
CN103189377B (zh) 2015-02-25
UY33694A (es) 2012-05-31
KR20140014078A (ko) 2014-02-05

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