RU2540337C2 - N1/N2-ЛАКТАМНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ - Google Patents
N1/N2-ЛАКТАМНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ Download PDFInfo
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- RU2540337C2 RU2540337C2 RU2013116924/04A RU2013116924A RU2540337C2 RU 2540337 C2 RU2540337 C2 RU 2540337C2 RU 2013116924/04 A RU2013116924/04 A RU 2013116924/04A RU 2013116924 A RU2013116924 A RU 2013116924A RU 2540337 C2 RU2540337 C2 RU 2540337C2
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- mmol
- tert
- reaction mixture
- methyl
- carboxylic acid
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- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 293
- 150000003839 salts Chemical class 0.000 claims abstract description 52
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 claims abstract description 27
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 claims abstract description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 17
- 239000001257 hydrogen Substances 0.000 claims abstract description 15
- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 9
- 125000001309 chloro group Chemical group Cl* 0.000 claims abstract description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract description 5
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims abstract description 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 5
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims abstract description 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 16
- 239000003085 diluting agent Substances 0.000 claims description 13
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 432
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- 238000000034 method Methods 0.000 description 68
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 56
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Cited By (1)
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| US11325909B2 (en) | 2017-11-21 | 2022-05-10 | Pfizer Inc. | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-OXO-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypryridin-2-YL)benzoic acid |
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| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN103214327A (zh) * | 2013-03-22 | 2013-07-24 | 郑州泰基鸿诺药物科技有限公司 | 一种芳香环或芳杂环三氟甲基酮化合物及其制备方法 |
| CN104230922B (zh) | 2013-06-19 | 2016-12-28 | 中国科学院上海药物研究所 | 一类五元杂环并吡啶类化合物及其制备方法和用途 |
| BR112016004118A2 (pt) | 2013-09-12 | 2017-10-17 | Pfizer | uso de inibidores da acetil-coa carboxilase para tratamento de acne vulgar |
| KR20160104065A (ko) | 2014-01-03 | 2016-09-02 | 바이엘 애니멀 헬스 게엠베하 | 농약으로서의 신규 피라졸릴헤테로아릴아미드 |
| CN104844509A (zh) * | 2014-02-14 | 2015-08-19 | 河南工业大学 | 一种条件温和无金属参与的胺基喹啉衍生物的制备方法 |
| KR101731624B1 (ko) * | 2014-07-01 | 2017-05-04 | 광주과학기술원 | 세포 리프로그래밍 유도용 조성물 |
| CN104610143A (zh) * | 2015-02-12 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一种含硝基喹啉结构的葡萄糖激酶活化剂及其用途 |
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| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
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| JP7282039B2 (ja) * | 2017-03-16 | 2023-05-26 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤、その合成、およびそれに至るまでの中間体 |
| WO2018166493A1 (zh) | 2017-03-16 | 2018-09-20 | 江苏恒瑞医药股份有限公司 | 杂芳基并[4，3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用 |
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| TW202019905A (zh) | 2018-07-24 | 2020-06-01 | 瑞士商赫孚孟拉羅股份公司 | 異喹啉化合物及其用途 |
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| CN109824669A (zh) * | 2018-12-21 | 2019-05-31 | 西南大学 | 哌啶螺环酒石酸类化合物制备及应用 |
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| TW202246282A (zh) | 2021-02-01 | 2022-12-01 | 美商西建公司 | Ｍｋ２抑制劑、其合成及其中間體 |
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| TW202602453A (zh) * | 2024-03-14 | 2026-01-16 | 智擎生技製藥股份有限公司 | Mta協同性的prmt5抑制劑 |
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2011
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200900613A1 (ru) * | 2006-11-29 | 2009-10-30 | Пфайзер Продактс Инк. | Спирокетоновые ингибиторы ацетил-коа-карбоксилаз |
| EP2123652A1 (en) * | 2007-02-20 | 2009-11-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11325909B2 (en) | 2017-11-21 | 2022-05-10 | Pfizer Inc. | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-OXO-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypryridin-2-YL)benzoic acid |
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