CY1116405T1 - Ν1/ν2-λακταμικοι αναστολεις ακετυλο-coa καρβοξυλασης - Google Patents
Ν1/ν2-λακταμικοι αναστολεις ακετυλο-coa καρβοξυλασηςInfo
- Publication number
- CY1116405T1 CY1116405T1 CY20151100518T CY151100518T CY1116405T1 CY 1116405 T1 CY1116405 T1 CY 1116405T1 CY 20151100518 T CY20151100518 T CY 20151100518T CY 151100518 T CY151100518 T CY 151100518T CY 1116405 T1 CY1116405 T1 CY 1116405T1
- Authority
- CY
- Cyprus
- Prior art keywords
- formula
- coa
- acetylo
- lactamic
- inactions
- Prior art date
Links
- 230000021523 carboxylation Effects 0.000 title 1
- 238000006473 carboxylation reaction Methods 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 abstract 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 abstract 1
- 108010018763 Biotin carboxylase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40812710P | 2010-10-29 | 2010-10-29 | |
| US201161531744P | 2011-09-07 | 2011-09-07 | |
| EP11784783.0A EP2632925B1 (en) | 2010-10-29 | 2011-10-18 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116405T1 true CY1116405T1 (el) | 2017-02-08 |
Family
ID=44993633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100518T CY1116405T1 (el) | 2010-10-29 | 2015-06-12 | Ν1/ν2-λακταμικοι αναστολεις ακετυλο-coa καρβοξυλασης |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8859773B2 (enExample) |
| EP (2) | EP2632925B1 (enExample) |
| JP (2) | JP5647356B2 (enExample) |
| KR (2) | KR101529404B1 (enExample) |
| CN (2) | CN103189377B (enExample) |
| AR (1) | AR083578A1 (enExample) |
| AU (1) | AU2011322117B2 (enExample) |
| BR (1) | BR112013010310A2 (enExample) |
| CA (1) | CA2815169C (enExample) |
| CY (1) | CY1116405T1 (enExample) |
| DK (1) | DK2632925T3 (enExample) |
| ES (1) | ES2546465T3 (enExample) |
| HK (1) | HK1209733A1 (enExample) |
| HU (1) | HUE025078T2 (enExample) |
| IL (1) | IL225779A0 (enExample) |
| MX (1) | MX2013004733A (enExample) |
| NZ (1) | NZ609527A (enExample) |
| PL (1) | PL2632925T3 (enExample) |
| PT (1) | PT2632925E (enExample) |
| RU (1) | RU2540337C2 (enExample) |
| SG (1) | SG189883A1 (enExample) |
| SI (1) | SI2632925T1 (enExample) |
| TW (3) | TWI507406B (enExample) |
| UY (1) | UY33694A (enExample) |
| WO (1) | WO2012056372A1 (enExample) |
| ZA (1) | ZA201303882B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103189377B (zh) * | 2010-10-29 | 2015-02-25 | 辉瑞大药厂 | N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂 |
| PT2953942T (pt) | 2013-02-06 | 2018-01-17 | Bayer Cropscience Ag | Derivados de pirazol substituídos com halogéneo como agentes pesticidas |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN103214327A (zh) * | 2013-03-22 | 2013-07-24 | 郑州泰基鸿诺药物科技有限公司 | 一种芳香环或芳杂环三氟甲基酮化合物及其制备方法 |
| CN104230922B (zh) | 2013-06-19 | 2016-12-28 | 中国科学院上海药物研究所 | 一类五元杂环并吡啶类化合物及其制备方法和用途 |
| MX2016002479A (es) | 2013-09-12 | 2016-05-31 | Pfizer | Uso de inhibidores de acetil-coa carboxilasa para tratar acne vulgaris. |
| WO2015101622A1 (de) | 2014-01-03 | 2015-07-09 | Bayer Cropscience Ag | Neue pyrazolyl-heteroarylamide als schädlingsbekämpfungsmittel |
| CN104844509A (zh) * | 2014-02-14 | 2015-08-19 | 河南工业大学 | 一种条件温和无金属参与的胺基喹啉衍生物的制备方法 |
| KR101731624B1 (ko) * | 2014-07-01 | 2017-05-04 | 광주과학기술원 | 세포 리프로그래밍 유도용 조성물 |
| CN104610143A (zh) * | 2015-02-12 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一种含硝基喹啉结构的葡萄糖激酶活化剂及其用途 |
| AU2016231174B2 (en) | 2015-03-10 | 2020-09-10 | Bayer Animal Health Gmbh | Pyrazolyl-derivatives as pest control agents |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| KR20190129851A (ko) | 2017-03-16 | 2019-11-20 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도 |
| US11124525B2 (en) | 2017-03-16 | 2021-09-21 | Celgene Car Llc | Heteroaryl compounds useful as MK2 inhibitors |
| EP3596086A4 (en) | 2017-03-16 | 2020-12-16 | Celgene CAR LLC | MK2 INHIBITORS, THEIR SYNTHESIS AND THEIR INTERMEDIARIES |
| MX2019010302A (es) | 2017-03-30 | 2019-11-21 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1. |
| EP3713942B8 (en) | 2017-11-21 | 2023-04-12 | Pfizer Inc. | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid |
| JP7386841B2 (ja) | 2018-07-24 | 2023-11-27 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | イソキノリン化合物及びその使用 |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| TW202023558A (zh) | 2018-10-03 | 2020-07-01 | 美商建南德克公司 | 8-胺基異喹啉化合物及其用途 |
| CN109824669A (zh) * | 2018-12-21 | 2019-05-31 | 西南大学 | 哌啶螺环酒石酸类化合物制备及应用 |
| EP4149917B1 (en) * | 2020-05-12 | 2025-07-30 | Merck Sharp & Dohme LLC | Factor xi activation inhibitors |
| KR20230013126A (ko) * | 2020-05-21 | 2023-01-26 | 시오노기 앤드 컴파니, 리미티드 | 지방성 간질환의 치료용 의약 |
| EP4284805A1 (en) | 2021-02-01 | 2023-12-06 | Celgene Corporation | Mk2 inhibitors, the synthesis thereof, and intermediates thereto |
| US12655150B2 (en) | 2021-03-26 | 2026-06-16 | Cedilla Therapeutics, Inc. | TEAD inhibitors and uses thereof |
| WO2022272036A1 (en) * | 2021-06-25 | 2022-12-29 | Cedilla Therapeutics, Inc. | Tead inhibitors and uses thereof |
| US12655157B2 (en) * | 2022-07-29 | 2026-06-16 | Pfizer Inc. | Spiro[benzo[d]thiazole-6 ,4′-piperidine as ACC inhibitors |
| WO2024213044A1 (en) * | 2023-04-14 | 2024-10-17 | Beijing Double-Crane Runchuang Technology Co., Ltd. | Azacyclo-carbonyl-fused ring derivatives and use thereof |
| TW202530207A (zh) * | 2023-08-16 | 2025-08-01 | 智擎生技製藥股份有限公司 | Ｍｔａ協同性的ｐｒｍｔ５抑制劑 |
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| EP2406230A1 (en) | 2009-03-11 | 2012-01-18 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
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| CA2778316A1 (en) * | 2009-11-10 | 2011-05-19 | Pfizer Inc. | N-2 pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| UA102336C2 (uk) * | 2009-11-10 | 2013-06-25 | Пфайзер Інк. | N1-ПІРАЗОЛСПІРОКЕТОНИ ЯК ІНГІБІТОРИ АЦЕТИЛ-СоА-КАРБОКСИЛАЗ |
| DK2621493T3 (en) | 2010-09-30 | 2016-10-24 | Pfizer | N1 PYRAZOLOSPIROKETON-ACETYL-CoA carboxylase INHIBITORS |
| CN103189377B (zh) * | 2010-10-29 | 2015-02-25 | 辉瑞大药厂 | N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂 |
-
2011
- 2011-10-18 CN CN201180052416.2A patent/CN103189377B/zh not_active Expired - Fee Related
- 2011-10-18 DK DK11784783.0T patent/DK2632925T3/en active
- 2011-10-18 EP EP11784783.0A patent/EP2632925B1/en not_active Not-in-force
- 2011-10-18 ES ES11784783.0T patent/ES2546465T3/es active Active
- 2011-10-18 SG SG2013027446A patent/SG189883A1/en unknown
- 2011-10-18 MX MX2013004733A patent/MX2013004733A/es unknown
- 2011-10-18 WO PCT/IB2011/054643 patent/WO2012056372A1/en not_active Ceased
- 2011-10-18 RU RU2013116924/04A patent/RU2540337C2/ru not_active IP Right Cessation
- 2011-10-18 SI SI201130519T patent/SI2632925T1/sl unknown
- 2011-10-18 CN CN201510087893.2A patent/CN104774205A/zh active Pending
- 2011-10-18 EP EP15164071.1A patent/EP2952514A1/en not_active Withdrawn
- 2011-10-18 PT PT117847830T patent/PT2632925E/pt unknown
- 2011-10-18 CA CA2815169A patent/CA2815169C/en not_active Expired - Fee Related
- 2011-10-18 KR KR1020137013652A patent/KR101529404B1/ko not_active Expired - Fee Related
- 2011-10-18 NZ NZ609527A patent/NZ609527A/en not_active IP Right Cessation
- 2011-10-18 JP JP2013535549A patent/JP5647356B2/ja not_active Expired - Fee Related
- 2011-10-18 HU HUE11784783A patent/HUE025078T2/en unknown
- 2011-10-18 BR BR112013010310A patent/BR112013010310A2/pt not_active IP Right Cessation
- 2011-10-18 PL PL11784783T patent/PL2632925T3/pl unknown
- 2011-10-18 AU AU2011322117A patent/AU2011322117B2/en not_active Ceased
- 2011-10-18 KR KR20147036653A patent/KR20150006899A/ko not_active Withdrawn
- 2011-10-26 TW TW103102453A patent/TWI507406B/zh not_active IP Right Cessation
- 2011-10-26 TW TW100138909A patent/TWI441823B/zh not_active IP Right Cessation
- 2011-10-26 TW TW104115757A patent/TW201531472A/zh unknown
- 2011-10-27 US US13/282,964 patent/US8859773B2/en active Active
- 2011-10-27 AR ARP110103976A patent/AR083578A1/es unknown
- 2011-10-28 UY UY0001033694A patent/UY33694A/es not_active Application Discontinuation
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2013
- 2013-04-15 IL IL225779A patent/IL225779A0/en unknown
- 2013-05-28 ZA ZA2013/03882A patent/ZA201303882B/en unknown
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2014
- 2014-09-26 US US14/497,396 patent/US8993586B2/en active Active
- 2014-11-05 JP JP2014225021A patent/JP2015057416A/ja not_active Withdrawn
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2015
- 2015-02-13 US US14/621,723 patent/US9181252B2/en active Active
- 2015-06-12 CY CY20151100518T patent/CY1116405T1/el unknown
- 2015-10-22 HK HK15110405.1A patent/HK1209733A1/xx unknown
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