CN103189377B - N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂 - Google Patents

N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂 Download PDF

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Publication number
CN103189377B
CN103189377B CN201180052416.2A CN201180052416A CN103189377B CN 103189377 B CN103189377 B CN 103189377B CN 201180052416 A CN201180052416 A CN 201180052416A CN 103189377 B CN103189377 B CN 103189377B
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mmol
reaction
tert
carboxylic acid
butyl
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Expired - Fee Related
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Chinese (zh)
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CN103189377A (zh
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S·W·巴格利
R·L·道
D·A·格里菲斯
A·C·史密斯
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201180052416.2A 2010-10-29 2011-10-18 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂 Expired - Fee Related CN103189377B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510087893.2A CN104774205A (zh) 2010-10-29 2011-10-18 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40812710P 2010-10-29 2010-10-29
US61/408,127 2010-10-29
US201161531744P 2011-09-07 2011-09-07
US61/531,744 2011-09-07
PCT/IB2011/054643 WO2012056372A1 (en) 2010-10-29 2011-10-18 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS

Related Child Applications (1)

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CN201510087893.2A Division CN104774205A (zh) 2010-10-29 2011-10-18 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂

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CN103189377A CN103189377A (zh) 2013-07-03
CN103189377B true CN103189377B (zh) 2015-02-25

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CN201510087893.2A Pending CN104774205A (zh) 2010-10-29 2011-10-18 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂

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UY (1) UY33694A (enExample)
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JP2013542218A (ja) 2013-11-21
TWI441823B (zh) 2014-06-21
TW201302751A (zh) 2013-01-16
HUE025078T2 (en) 2016-01-28
US9181252B2 (en) 2015-11-10
US20150025098A1 (en) 2015-01-22
AR083578A1 (es) 2013-03-06
KR101529404B1 (ko) 2015-06-26
US8993586B2 (en) 2015-03-31
US20120108619A1 (en) 2012-05-03
TW201531472A (zh) 2015-08-16
CA2815169A1 (en) 2012-05-03
US20150152109A1 (en) 2015-06-04
TW201418256A (zh) 2014-05-16
HK1186724A1 (en) 2014-03-21
ZA201303882B (en) 2014-02-26
US8859773B2 (en) 2014-10-14
PT2632925E (pt) 2015-09-01
KR20140014078A (ko) 2014-02-05
NZ609527A (en) 2014-03-28
EP2952514A1 (en) 2015-12-09
JP2015057416A (ja) 2015-03-26
EP2632925B1 (en) 2015-05-27
EP2632925A1 (en) 2013-09-04
CY1116405T1 (el) 2017-02-08
PL2632925T3 (pl) 2015-10-30
WO2012056372A1 (en) 2012-05-03
CN104774205A (zh) 2015-07-15
ES2546465T3 (es) 2015-09-23
IL225779A0 (en) 2013-06-27
AU2011322117A1 (en) 2013-05-02
RU2540337C2 (ru) 2015-02-10
SI2632925T1 (sl) 2015-07-31
CA2815169C (en) 2015-10-06
AU2011322117B2 (en) 2015-01-22
RU2013116924A (ru) 2014-12-10
UY33694A (es) 2012-05-31
MX2013004733A (es) 2013-07-02
SG189883A1 (en) 2013-06-28
JP5647356B2 (ja) 2014-12-24
BR112013010310A2 (pt) 2016-11-29
HK1209733A1 (en) 2016-04-08
TWI507406B (zh) 2015-11-11
KR20150006899A (ko) 2015-01-19
DK2632925T3 (en) 2015-06-29
CN103189377A (zh) 2013-07-03

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