KR101401159B1 - 가변 부위에 글리코실화를 가지는 아밀로이드 베타에 대한 항체 - Google Patents

가변 부위에 글리코실화를 가지는 아밀로이드 베타에 대한 항체 Download PDF

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KR101401159B1
KR101401159B1 KR1020127010552A KR20127010552A KR101401159B1 KR 101401159 B1 KR101401159 B1 KR 101401159B1 KR 1020127010552 A KR1020127010552 A KR 1020127010552A KR 20127010552 A KR20127010552 A KR 20127010552A KR 101401159 B1 KR101401159 B1 KR 101401159B1
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antibody
glycosylated
amyloid
composition
seq
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KR20120089483A (ko
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한스루에디 로에트쉬에르
발테르 후베르
디아나 쉬우흐바우에르
카를 베예르
맨프레드 브로크하우스
베른드 보어만
한스 콜
안드레아스 쉬아우브마르
쿠르트 란그
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에프. 호프만-라 로슈 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
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  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020127010552A 2005-12-12 2006-12-11 가변 부위에 글리코실화를 가지는 아밀로이드 베타에 대한 항체 Active KR101401159B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05027090.9 2005-12-12
EP05027090 2005-12-12
PCT/EP2006/011914 WO2007068429A1 (en) 2005-12-12 2006-12-11 Antibodies against amyloid beta 4 with glycosylated in the variable region

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KR1020087012289A Division KR20080077132A (ko) 2005-12-12 2006-12-11 가변 부위에 글리코실화된, 아밀로이드 베타 4에 대한 항체

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KR20120089483A KR20120089483A (ko) 2012-08-10
KR101401159B1 true KR101401159B1 (ko) 2014-05-29

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KR1020127010552A Active KR101401159B1 (ko) 2005-12-12 2006-12-11 가변 부위에 글리코실화를 가지는 아밀로이드 베타에 대한 항체
KR1020087012289A Ceased KR20080077132A (ko) 2005-12-12 2006-12-11 가변 부위에 글리코실화된, 아밀로이드 베타 4에 대한 항체

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US (2) US8906370B2 (https=)
EP (2) EP1960428B1 (https=)
JP (1) JP5145241B2 (https=)
KR (2) KR101401159B1 (https=)
CN (2) CN102659943B (https=)
AR (1) AR057233A1 (https=)
AT (1) ATE517923T1 (https=)
AU (1) AU2006326301B2 (https=)
BR (1) BRPI0619605B8 (https=)
CA (1) CA2632828C (https=)
CR (1) CR10000A (https=)
CY (1) CY1114783T1 (https=)
DK (1) DK1960428T3 (https=)
DO (1) DOP2006000278A (https=)
EC (1) ECSP088524A (https=)
ES (1) ES2368591T3 (https=)
IL (1) IL191004A (https=)
JO (1) JO2824B1 (https=)
MA (1) MA30038B1 (https=)
MY (1) MY155286A (https=)
NO (1) NO346105B1 (https=)
NZ (1) NZ568241A (https=)
PE (3) PE20100684A1 (https=)
PL (1) PL1960428T3 (https=)
PT (1) PT1960428E (https=)
RS (1) RS52004B (https=)
RU (1) RU2438706C2 (https=)
SI (1) SI1960428T1 (https=)
TW (1) TWI382990B (https=)
UA (1) UA99097C2 (https=)
UY (1) UY30003A1 (https=)
WO (1) WO2007068429A1 (https=)
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