PE20100684A1 - Anticuerpo anti b-4-amiloide que contiene asparagina glicosilada en la region variable de vh - Google Patents
Anticuerpo anti b-4-amiloide que contiene asparagina glicosilada en la region variable de vhInfo
- Publication number
- PE20100684A1 PE20100684A1 PE2010000354A PE2010000354A PE20100684A1 PE 20100684 A1 PE20100684 A1 PE 20100684A1 PE 2010000354 A PE2010000354 A PE 2010000354A PE 2010000354 A PE2010000354 A PE 2010000354A PE 20100684 A1 PE20100684 A1 PE 20100684A1
- Authority
- PE
- Peru
- Prior art keywords
- variable region
- asparagine
- antibody containing
- amyloid antibody
- antibody
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05027090 | 2005-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20100684A1 true PE20100684A1 (es) | 2010-10-04 |
Family
ID=37745986
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000354A PE20100684A1 (es) | 2005-12-12 | 2006-12-11 | Anticuerpo anti b-4-amiloide que contiene asparagina glicosilada en la region variable de vh |
| PE2010000560A PE20100748A1 (es) | 2005-12-12 | 2006-12-11 | Anticuerpo anti beta-4-amiloide que contiene asparagina glicosilada en la region variable de vh |
| PE2006001587A PE20071002A1 (es) | 2005-12-12 | 2006-12-11 | Anticuerpo anti b4-amilode que contiene asparagina glicosilada en la region variable de vh |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000560A PE20100748A1 (es) | 2005-12-12 | 2006-12-11 | Anticuerpo anti beta-4-amiloide que contiene asparagina glicosilada en la region variable de vh |
| PE2006001587A PE20071002A1 (es) | 2005-12-12 | 2006-12-11 | Anticuerpo anti b4-amilode que contiene asparagina glicosilada en la region variable de vh |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8906370B2 (https=) |
| EP (2) | EP1960428B1 (https=) |
| JP (1) | JP5145241B2 (https=) |
| KR (2) | KR101401159B1 (https=) |
| CN (2) | CN102659943B (https=) |
| AR (1) | AR057233A1 (https=) |
| AT (1) | ATE517923T1 (https=) |
| AU (1) | AU2006326301B2 (https=) |
| BR (1) | BRPI0619605B8 (https=) |
| CA (1) | CA2632828C (https=) |
| CR (1) | CR10000A (https=) |
| CY (1) | CY1114783T1 (https=) |
| DK (1) | DK1960428T3 (https=) |
| DO (1) | DOP2006000278A (https=) |
| EC (1) | ECSP088524A (https=) |
| ES (1) | ES2368591T3 (https=) |
| IL (1) | IL191004A (https=) |
| JO (1) | JO2824B1 (https=) |
| MA (1) | MA30038B1 (https=) |
| MY (1) | MY155286A (https=) |
| NO (1) | NO346105B1 (https=) |
| NZ (1) | NZ568241A (https=) |
| PE (3) | PE20100684A1 (https=) |
| PL (1) | PL1960428T3 (https=) |
| PT (1) | PT1960428E (https=) |
| RS (1) | RS52004B (https=) |
| RU (1) | RU2438706C2 (https=) |
| SI (1) | SI1960428T1 (https=) |
| TW (1) | TWI382990B (https=) |
| UA (1) | UA99097C2 (https=) |
| UY (1) | UY30003A1 (https=) |
| WO (1) | WO2007068429A1 (https=) |
| ZA (1) | ZA200805038B (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| MY155286A (en) * | 2005-12-12 | 2015-09-30 | Hoffmann La Roche | Antibodies against amyloid beta 4 with glycosylated in the variable region |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| CL2007003583A1 (es) * | 2006-12-11 | 2008-07-18 | Hoffmann La Roche | Formulacion farmaceutica estable, parenteral, del anticuerpo contra el peptido beta amiloide (abeta); y uso de la formulacion para el tratamiento de la enfermedad de alzheimer. |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| JP5512514B2 (ja) * | 2007-06-29 | 2014-06-04 | エフ．ホフマン−ラ ロシュ アーゲー | 改善された免疫グロブリンの産生をもたらす重鎖変異体 |
| ES2840725T3 (es) * | 2007-08-20 | 2021-07-07 | Glaxo Group Ltd | Procedimiento de producción |
| AU2008311367B2 (en) | 2007-10-05 | 2014-11-13 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
| BRPI0820819B1 (pt) * | 2007-12-21 | 2021-06-08 | F. Hoffmann-La Roche Ag | formulação de anticorpos humanizados b-ly 1 e seu uso |
| WO2009135181A2 (en) * | 2008-05-02 | 2009-11-05 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| US20140213465A1 (en) * | 2011-12-02 | 2014-07-31 | Plaxgen, Inc. | Plaque array methods and compositions for forming and detecting plaques |
| US20120282654A1 (en) * | 2009-04-29 | 2012-11-08 | Schering Corporation | Antibody purification |
| US20130116413A1 (en) * | 2009-12-29 | 2013-05-09 | Dr. Reddy's Laboratories, Inc. | Purification of proteins |
| NZ601117A (en) | 2010-03-03 | 2014-06-27 | Boehringer Ingelheim Int | Biparatopic abeta binding polypeptides |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| EP2598882B1 (en) | 2010-07-30 | 2017-07-26 | AC Immune S.A. | Safe and functional humanized antibodies for use in treating an amyloidosis |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| CN107233569B (zh) * | 2011-10-25 | 2021-08-31 | 普罗西纳生物科学有限公司 | 抗体制剂和方法 |
| RS54644B1 (sr) * | 2012-03-08 | 2016-08-31 | F. Hoffmann-La Roche Ag | Formulacija abeta antitela |
| HUE045144T2 (hu) * | 2012-08-29 | 2019-12-30 | Hoffmann La Roche | Véragygát-shuttle |
| CN102998454A (zh) * | 2012-12-11 | 2013-03-27 | 华中师范大学 | 一种检测生物体内邻苯二甲酸二丁酯相对含量的方法 |
| US9587022B2 (en) | 2012-12-18 | 2017-03-07 | The Rockefeller University | Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity |
| EP2934589B1 (en) * | 2012-12-18 | 2021-01-13 | The Rockefeller University | Glycan-modified anti-cd4 antibodies for hiv prevention and therapy |
| EP3594230A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| JP6169885B2 (ja) | 2013-05-07 | 2017-07-26 | 株式会社日立製作所 | 精製装置及び精製方法 |
| RU2016107435A (ru) | 2013-09-13 | 2017-10-18 | Дженентек, Инк. | Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты |
| CN120904322A (zh) | 2013-09-13 | 2025-11-07 | 豪夫迈·罗氏有限公司 | 包含纯化的重组多肽的方法和组合物 |
| CN105899192B (zh) | 2013-11-22 | 2019-08-13 | 国立大学法人东京大学 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
| CA2944402A1 (en) | 2014-04-08 | 2015-10-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
| WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
| HUE057952T2 (hu) | 2015-06-24 | 2022-06-28 | Hoffmann La Roche | Anti-transzferrin receptor antitestek testreszabott affinitással |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| SI3337812T1 (sl) * | 2015-08-21 | 2021-08-31 | F. Hoffmann-La Roche Ag | Postopek za zmanjševanje beljakovin gostiteljske celice v afinitetni kromatografiji |
| TWI873952B (zh) | 2015-10-02 | 2025-02-21 | 瑞士商赫孚孟拉羅股份公司 | 雙特異性抗‐人類cd20/人類轉鐵蛋白受體抗體及使用方法 |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| HUE057085T2 (hu) * | 2015-10-16 | 2022-04-28 | Hoffmann La Roche | Egy rendszer mûködtetésére szolgáló eljárás és egy rendszer |
| KR102776187B1 (ko) | 2015-11-09 | 2025-03-07 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타에서의 n-말단 에피토프 및 이에 형태적으로-선택적인 항체 |
| AU2016353553B2 (en) | 2015-11-09 | 2022-01-20 | The University Of British Columbia | Amyloid beta epitopes and antibodies thereto |
| EP3374381A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | EPITOPES IN THE AMYLOID-BETA MEDIUM REGION AND CONFORMITY-SELECTIVE ANTIBODIES THEREOF |
| US10792477B2 (en) * | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
| EP3427183A1 (en) * | 2016-03-10 | 2019-01-16 | Genomic Vision | Method of curvilinear signal detection and analysis and associated platform |
| EP3448874A4 (en) * | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| TWI798751B (zh) | 2016-07-01 | 2023-04-11 | 美商美國禮來大藥廠 | 抗－N3pGlu類澱粉β肽抗體及其用途 |
| CN109476729A (zh) | 2016-07-18 | 2019-03-15 | 英属哥伦比亚大学 | 淀粉样蛋白β的抗体 |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| US20200113854A1 (en) * | 2017-05-30 | 2020-04-16 | Morinaga Milk Industry Co., Ltd. | Composition for Improving Brain Function |
| ES2984844T3 (es) | 2017-07-18 | 2024-10-31 | Univ British Columbia | Anticuerpos contra beta amiloide |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| CN108048477A (zh) * | 2017-12-15 | 2018-05-18 | 南京理工大学 | 基于大肠杆菌表达系统的制备多肽的方法 |
| EP3778875A1 (en) | 2019-08-14 | 2021-02-17 | MaxiVax SA | Immortalized myoblast cell lines and uses thereof |
| KR20230039734A (ko) | 2020-07-23 | 2023-03-21 | 오타이르 프로테나 리미티드 | 항-Aβ 항체 |
| IL302740A (en) * | 2020-11-16 | 2023-07-01 | Hoffmann La Roche | Fab high mannose glycoforms |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| CN114720543B (zh) * | 2022-04-06 | 2026-02-24 | 苏州大学 | 一种基于固相糖蛋白t抗原糖肽富集和酶切分析的方法 |
| CN114591429B (zh) * | 2022-05-07 | 2022-08-09 | 北京第一生物化学药业有限公司 | 结合β-淀粉样蛋白的抗体及其用途 |
| TW202434629A (zh) | 2023-01-26 | 2024-09-01 | 愛爾蘭商歐薩爾普羅席納有限公司 | 以抗類澱粉β (ABETA)抗體治療神經病症之方法 |
| CN121620524A (zh) | 2023-08-09 | 2026-03-06 | 豪夫迈·罗氏有限公司 | 抗A-β蛋白抗体、方法及其用途 |
| WO2025032069A1 (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof |
| CN117783359B (zh) * | 2023-12-28 | 2024-12-31 | 中国计量科学研究院 | 一种基于串联质谱的转基因蛋白多靶同检方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5811310A (en) | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| CA1339014C (en) | 1987-10-08 | 1997-03-25 | Ronald E. Majocha | Antibodies to a4 amyloid peptide |
| JP2780507B2 (ja) | 1991-03-29 | 1998-07-30 | 松下電器産業株式会社 | 内燃機関用フィルタ再生装置 |
| US5955317A (en) | 1993-01-25 | 1999-09-21 | Takeda Chemical Industries, Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
| ATE239797T1 (de) | 1993-01-25 | 2003-05-15 | Takeda Chemical Industries Ltd | Antikörper gegen beta-amyloid oder derivative davon und seine verwendung |
| US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
| GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| US5688651A (en) | 1994-12-16 | 1997-11-18 | Ramot University Authority For Applied Research And Development Ltd. | Prevention of protein aggregation |
| WO1996039628A1 (en) * | 1995-06-06 | 1996-12-12 | Stemcell Therapeutics L.L.C. | GLYCOPROTEIN gp105 ON BL3 HEMATOPOIETIC STEM CELLS |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| ATE366259T1 (de) * | 1999-03-04 | 2007-07-15 | Praecis Pharm Inc | Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren |
| AU780474B2 (en) | 1999-06-16 | 2005-03-24 | Boston Biomedical Research Institute Incorporated | Immunological control of beta-amyloid levels in vivo |
| EP1209969A2 (en) | 1999-08-31 | 2002-06-05 | RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. | Peptides and substances, methods and devices using same for diagnosing and treating neurodegenerative disorders |
| MXPA02005576A (es) | 1999-11-29 | 2002-12-13 | Neurochem Inc | Vacuna para la prevencion y tratamiento de la enfermedad de alzheimer y otras enfermedades relacionadas con amiloides. |
| US20020094335A1 (en) | 1999-11-29 | 2002-07-18 | Robert Chalifour | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
| EP1125905A1 (en) | 2000-02-16 | 2001-08-22 | Pepscan Systems B.V. | Segment synthesis |
| DE1257584T1 (de) | 2000-02-24 | 2003-05-28 | Lilly Co Eli | Humanisierte antikörper, die amyloid beta peptid demarkieren |
| CA2313828A1 (en) | 2000-08-01 | 2002-02-01 | Institut De Recherches Cliniques De Montreal/Ircm | Post-translational processing of .beta.-secretase (bace): the pro-and transmembrane/cytosolic domains affect its cellular activity and amyloid a.beta. production |
| PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| ATE385811T1 (de) | 2000-12-19 | 2008-03-15 | Palatin Technologies Inc | Identifizierung zielgerichteter faltungsstellen in peptiden und proteinen |
| EP2165714B1 (en) | 2001-04-30 | 2013-10-23 | Eli Lilly And Company | Humanized antibodies recognizing the beta-amyloid peptide |
| EP1385544B1 (en) | 2001-04-30 | 2008-09-24 | Eli Lilly And Company | Humanized antibodies |
| CA2451998A1 (en) * | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Anti-a.beta. antibodies |
| PT1944040E (pt) * | 2001-08-17 | 2012-10-31 | Univ Washington | Método de avaliação para a doença de alzheimer |
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| US20040146512A1 (en) | 2002-10-09 | 2004-07-29 | Arnon Rosenthal | Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
| DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| MY155286A (en) * | 2005-12-12 | 2015-09-30 | Hoffmann La Roche | Antibodies against amyloid beta 4 with glycosylated in the variable region |
| CL2007003583A1 (es) * | 2006-12-11 | 2008-07-18 | Hoffmann La Roche | Formulacion farmaceutica estable, parenteral, del anticuerpo contra el peptido beta amiloide (abeta); y uso de la formulacion para el tratamiento de la enfermedad de alzheimer. |
-
2006
- 2006-12-11 MY MYPI20081349A patent/MY155286A/en unknown
- 2006-12-11 PE PE2010000354A patent/PE20100684A1/es not_active Application Discontinuation
- 2006-12-11 NZ NZ568241A patent/NZ568241A/en unknown
- 2006-12-11 UA UAA200808791A patent/UA99097C2/ru unknown
- 2006-12-11 PE PE2010000560A patent/PE20100748A1/es active IP Right Grant
- 2006-12-11 RS RS20110401A patent/RS52004B/sr unknown
- 2006-12-11 JP JP2008543748A patent/JP5145241B2/ja active Active
- 2006-12-11 EP EP06829502A patent/EP1960428B1/en active Active
- 2006-12-11 PL PL06829502T patent/PL1960428T3/pl unknown
- 2006-12-11 EP EP11169488A patent/EP2377886A1/en not_active Withdrawn
- 2006-12-11 NO NO20082874A patent/NO346105B1/no unknown
- 2006-12-11 UY UY30003A patent/UY30003A1/es unknown
- 2006-12-11 DK DK06829502.1T patent/DK1960428T3/da active
- 2006-12-11 KR KR1020127010552A patent/KR101401159B1/ko active Active
- 2006-12-11 WO PCT/EP2006/011914 patent/WO2007068429A1/en not_active Ceased
- 2006-12-11 RU RU2008128138/10A patent/RU2438706C2/ru active
- 2006-12-11 PT PT06829502T patent/PT1960428E/pt unknown
- 2006-12-11 AR ARP060105433A patent/AR057233A1/es unknown
- 2006-12-11 CN CN201210137369.8A patent/CN102659943B/zh active Active
- 2006-12-11 US US12/086,309 patent/US8906370B2/en active Active
- 2006-12-11 KR KR1020087012289A patent/KR20080077132A/ko not_active Ceased
- 2006-12-11 JO JO2006444A patent/JO2824B1/en active
- 2006-12-11 SI SI200631096T patent/SI1960428T1/sl unknown
- 2006-12-11 CA CA2632828A patent/CA2632828C/en active Active
- 2006-12-11 CN CN2006800463079A patent/CN101351476B/zh active Active
- 2006-12-11 DO DO2006000278A patent/DOP2006000278A/es unknown
- 2006-12-11 BR BRPI0619605A patent/BRPI0619605B8/pt active IP Right Grant
- 2006-12-11 PE PE2006001587A patent/PE20071002A1/es not_active Application Discontinuation
- 2006-12-11 TW TW095146304A patent/TWI382990B/zh active
- 2006-12-11 ES ES06829502T patent/ES2368591T3/es active Active
- 2006-12-11 AU AU2006326301A patent/AU2006326301B2/en active Active
- 2006-12-11 AT AT06829502T patent/ATE517923T1/de active
-
2008
- 2008-04-27 IL IL191004A patent/IL191004A/en active IP Right Grant
- 2008-05-20 CR CR10000A patent/CR10000A/es unknown
- 2008-06-09 MA MA31014A patent/MA30038B1/fr unknown
- 2008-06-10 EC EC2008008524A patent/ECSP088524A/es unknown
- 2008-06-10 ZA ZA200805038A patent/ZA200805038B/xx unknown
-
2011
- 2011-09-16 CY CY20111100899T patent/CY1114783T1/el unknown
-
2014
- 2014-11-07 US US14/536,262 patent/US9272031B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20100684A1 (es) | Anticuerpo anti b-4-amiloide que contiene asparagina glicosilada en la region variable de vh | |
| PE20081634A1 (es) | Fab ab pegilado | |
| CR20150016A (es) | Anticuerpo monoclonal | |
| CL2012001817A1 (es) | Anticuerpo monoclonal que reconoce epitope conformacional y se une a peptidos amiloides solubles polimericos y peptidos amiloides oligomericos, particularmente a los peptidos abeta amiloides solubles polimericos y peptidos abeta amiloides oligomericos; polinucleotidos que codifican dicho anticuerpo; composicion terapeutica que comprende el anticuerpo; uso del anticuerpo para tratar enfermedades y trastornos causados o asociados a las proteinas amiloides (div. sol. 1742-2008). | |
| ATE414106T1 (de) | Pegylierte single-domain-antikörper (dab) | |
| SA519401647B1 (ar) | y مركبات ببتيد تيروسين-تيروسين الحلقية المقترنة بجسم مضاد كمعدلات لمستقبلات الببتيد العصبي | |
| WO2010012004A3 (en) | Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence | |
| UA102667C2 (uk) | Людське нейтралізуюче антитіло проти в7rp1 | |
| EA201190018A1 (ru) | Миостатинсвязывающие белки | |
| CL2013000390A1 (es) | Anticuerpo monoclonal que se une al peptido beta amiloide n3pglu o fragmento de union a antigeno del mismo; composicion farmaceutica que lo comprende; y su uso para tratar la enfermedad de alzheimer. | |
| CL2008003197A1 (es) | Anticuerpo que se une especificamente a la region n-terminal del peptido alfa-beta8-x; hibridoma y proceso de preparacion del anticuerpo; metodo para detectar la carga amiloide in vitro en un mamifero; kit, composicion terapeutica y de vacuna que comprenden al anticuerpo; uso del anticuerpo para tratar la enfermedad de alzheimer. | |
| EA201100694A1 (ru) | Антитело к cd38 человека и его применение | |
| DOP2010000097A (es) | Anticuerpos especificos para la forma de protofibrillas de la proteina beta-amiloide | |
| AR085198A1 (es) | Composicion farmaceutica | |
| JO3188B1 (ar) | بروتينات رابطة لمولد الضد محددة لمكون p لنظير النشا بالمصل | |
| WO2007098607A8 (en) | Methods and compositions to treat and detect misfolded-sod1 mediated diseases | |
| BRPI0506771A (pt) | anticorpo, e, composição farmacêutica | |
| EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
| EP2532366A4 (en) | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF CANCER | |
| JP2016531546A5 (https=) | ||
| BR112012007563A2 (pt) | peptídeos sintéticos antagonistas de miostatina | |
| DK1786442T3 (da) | Behandling af neurodegenerative sygdomme under anvendelse af DEGS-inhibitorer | |
| DK1969003T3 (da) | Anvendelser af et neurotrofisk faktor-protein | |
| DK1937827T3 (da) | Antistoffer og deres anvendelse til behandling, forebyggelse og diagnose af en sygdom forbundet med SOD | |
| WO2006137938A3 (en) | Antibody fragments for protection from pathogen infection and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |