ATE366259T1 - Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren - Google Patents
Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäurenInfo
- Publication number
- ATE366259T1 ATE366259T1 AT00916028T AT00916028T ATE366259T1 AT E366259 T1 ATE366259 T1 AT E366259T1 AT 00916028 T AT00916028 T AT 00916028T AT 00916028 T AT00916028 T AT 00916028T AT E366259 T1 ATE366259 T1 AT E366259T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide
- amyloid peptide
- group
- compounds
- amino
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 150000008574 D-amino acids Chemical class 0.000 title abstract 4
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 4
- 230000006919 peptide aggregation Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 125000003368 amide group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 1
- 229930182819 D-leucine Natural products 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- 229930182832 D-phenylalanine Natural products 0.000 abstract 1
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 abstract 1
- 229930182831 D-valine Natural products 0.000 abstract 1
- 230000003942 amyloidogenic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12273699P | 1999-03-04 | 1999-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366259T1 true ATE366259T1 (de) | 2007-07-15 |
Family
ID=22404455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00916028T ATE366259T1 (de) | 1999-03-04 | 2000-03-03 | Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6610658B1 (de) |
| EP (1) | EP1161449B1 (de) |
| JP (2) | JP2002543043A (de) |
| KR (1) | KR100771712B1 (de) |
| CN (1) | CN1279053C (de) |
| AT (1) | ATE366259T1 (de) |
| AU (1) | AU781292B2 (de) |
| BR (1) | BR0008738A (de) |
| CA (1) | CA2362834C (de) |
| CY (1) | CY1106899T1 (de) |
| DE (1) | DE60035412T2 (de) |
| DK (1) | DK1161449T3 (de) |
| ES (1) | ES2290023T3 (de) |
| HK (1) | HK1040722B (de) |
| NZ (1) | NZ514414A (de) |
| PT (1) | PT1161449E (de) |
| RU (1) | RU2260599C2 (de) |
| WO (1) | WO2000052048A1 (de) |
| ZA (1) | ZA200107913B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277826B1 (en) * | 1996-08-27 | 2001-08-21 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| EP0866805A1 (de) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | Peptide, das die KLVFF Sequenz von beta-Amyloid bindet |
| ES2290023T3 (es) * | 1999-03-04 | 2008-02-16 | Praecis Pharmaceuticals Incorporated | Moduladores de la agregacion del peptido beta-amiloide que comprenden d-aminoacidos. |
| US7060670B1 (en) * | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| GB9917725D0 (en) * | 1999-07-28 | 1999-09-29 | Medical Res Council | Peptides |
| US20070135337A2 (en) * | 1999-11-29 | 2007-06-14 | Neurochem (International) Limited | Vaccine for the Prevention and Treatment of Alzheimer's and Amyloid Related Diseases |
| US20020094335A1 (en) * | 1999-11-29 | 2002-07-18 | Robert Chalifour | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
| CA2398567A1 (en) * | 2000-02-11 | 2001-08-16 | Praecis Pharmaceuticals Incorporated | Methods for enhancing the bioavailability of a drug |
| AUPR215700A0 (en) * | 2000-12-19 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid compound having cyclopropane ring |
| DE10117281A1 (de) * | 2001-04-06 | 2002-10-24 | Inst Molekulare Biotechnologie | Peptid zur Diagnose und Therapie der Alzheimer-Demenz |
| AU2003222415B2 (en) | 2002-04-18 | 2009-02-05 | Yeda Research And Development Co. Ltd. | Derivatives of the IL-2 receptor gamma chain, their production and use |
| WO2004058239A1 (en) * | 2002-12-24 | 2004-07-15 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| CN100340599C (zh) * | 2003-06-09 | 2007-10-03 | 湖南大学 | 多聚赖氨酸淀粉纳米颗粒与制备方法及作为基因载体的应用 |
| CA2535663C (en) * | 2003-08-12 | 2011-02-08 | Paul Alan Cox | Neurotoxic amino acid or neurotoxic derivative thereof associated with neurological disorders |
| GB0503434D0 (en) * | 2005-02-18 | 2005-03-30 | Senexis Ltd | Amyloid-binding peptides, analogues and uses thereof |
| CA2632828C (en) * | 2005-12-12 | 2012-07-10 | F. Hoffmann-La Roche Ag | Antibodies against amyloid beta with glycosylation in the variable region |
| EP2121633A2 (de) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazinderivate zur behandlung von alzheimer-krankheit und verwandten leiden |
| RU2372355C1 (ru) * | 2008-06-27 | 2009-11-10 | Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН | Пептид, обладающий защитным действием против болезни альцгеймера |
| DE102008037564A1 (de) * | 2008-11-19 | 2010-05-20 | Forschungszentrum Jülich GmbH | Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden |
| EP2510357B1 (de) * | 2009-12-07 | 2016-03-30 | Pieris AG | Muteine von humanem lipocalin 2 (lcn2, hngal) mit affinität für ein bestimmtes zielmolekül |
| JP2014529630A (ja) | 2011-09-07 | 2014-11-13 | ザウラー−ブロシュ、ローラント | 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤 |
| US10653631B2 (en) | 2011-09-07 | 2020-05-19 | Roland SAUR-BROSCH | Optimal colon targeting technology |
| KR101437354B1 (ko) * | 2012-07-27 | 2014-09-05 | 한국과학기술연구원 | 고수율 및 고순도의 아밀로이드-베타 펩타이드의 제조방법 |
| JPWO2022211014A1 (de) * | 2021-03-31 | 2022-10-06 | ||
| KR20230128606A (ko) * | 2022-02-28 | 2023-09-05 | 경상국립대학교산학협력단 | 티로신을 유효성분으로 함유하는 알츠하이머병의 예방, 개선 또는 치료용 조성물 |
| KR20250010000A (ko) * | 2022-05-27 | 2025-01-20 | 주식회사 진큐어 | 신규 펩타이드 및 그의 용도 |
| CN119403821A (zh) * | 2022-05-27 | 2025-02-07 | 锌医疗公司 | 新型肽及其用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR82516E (fr) * | 1962-10-11 | 1964-02-28 | Ciba Geigy | Procédé de préparation de dérivés peptidiques, notamment d'hydrazides peptidiques |
| US4119493A (en) | 1975-10-23 | 1978-10-10 | (Zaidanhojin) Sagami Chemical Research Center | Process for producing a peptide |
| US5284664A (en) | 1988-08-04 | 1994-02-08 | Kremers-Urban Company | Method of treating the symptoms of Alzheimer's disease |
| US5652214A (en) | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US5338663A (en) | 1990-08-24 | 1994-08-16 | President And Fellows Of Harvard College | Method of identifying inhibitors of β-protein esterase activity |
| US5434050A (en) | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
| MD960317A (ro) * | 1991-11-19 | 1998-05-31 | Anylin Pharmaceuticals, Inc. | Noile peptide-agoniste ale amilinei şi utilizarea lor |
| US5338837A (en) | 1991-12-13 | 1994-08-16 | The Trustees Of Princeton University | Glycosylated steroid derivatives for transport across biological membranes and process for making same |
| US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US6120768A (en) | 1993-05-17 | 2000-09-19 | Immunomedics, Inc. | Dota-biotin derivatives |
| AU7043894A (en) | 1993-05-28 | 1994-12-20 | Miriam Hospital, The | Composition and method for (in vivo) imaging of amyloid deposits |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
| CA2125467C (en) | 1993-07-06 | 2001-02-06 | Heinz Dobeli | Process for producing hydrophobic polypeptides, proteins or peptides |
| WO1995005604A2 (en) | 1993-08-13 | 1995-02-23 | Molecular Geriatrics Corporation | Methods for the diagnosis of alzheimer's disease |
| GB9317120D0 (en) | 1993-08-17 | 1993-09-29 | Royal Postgrad Med School | Human serum amyloid p component |
| US5652334A (en) | 1993-09-08 | 1997-07-29 | City Of Hope | Method for design of substances that enhance memory and improve the quality of life |
| US5470951A (en) | 1993-09-29 | 1995-11-28 | City Of Hope | Peptides for antagonizing the effects of amyloid βprotein |
| US5744368A (en) | 1993-11-04 | 1998-04-28 | Research Foundation Of State University Of New York | Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR) |
| JPH07149668A (ja) | 1993-11-30 | 1995-06-13 | Kanegafuchi Chem Ind Co Ltd | アミロイド沈着検出用物質 |
| CA2182731A1 (en) | 1994-02-03 | 1995-08-10 | Michael P. Vitek | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis |
| US6303567B1 (en) * | 1995-03-14 | 2001-10-16 | Praecis Pharmaceuticals, Inc . | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| US5854204A (en) * | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals, Inc. | Aβ peptides that modulate β-amyloid aggregation |
| US5767233A (en) | 1995-05-12 | 1998-06-16 | Schering Corporation | Soluble cleavable substrates of the hepatitis C virus protease |
| US5985242A (en) | 1995-10-27 | 1999-11-16 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| US6277826B1 (en) * | 1996-08-27 | 2001-08-21 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| EP0866805A1 (de) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | Peptide, das die KLVFF Sequenz von beta-Amyloid bindet |
| CA2262453A1 (en) * | 1996-08-27 | 1998-03-05 | Praecis Pharmaceuticals Incorporated | Modulators of .beta.-amyloid peptide aggregation comprising d-amino acids |
| ES2290023T3 (es) * | 1999-03-04 | 2008-02-16 | Praecis Pharmaceuticals Incorporated | Moduladores de la agregacion del peptido beta-amiloide que comprenden d-aminoacidos. |
-
2000
- 2000-03-03 ES ES00916028T patent/ES2290023T3/es not_active Expired - Lifetime
- 2000-03-03 DK DK00916028T patent/DK1161449T3/da active
- 2000-03-03 EP EP00916028A patent/EP1161449B1/de not_active Expired - Lifetime
- 2000-03-03 NZ NZ514414A patent/NZ514414A/xx unknown
- 2000-03-03 US US09/519,019 patent/US6610658B1/en not_active Expired - Fee Related
- 2000-03-03 DE DE60035412T patent/DE60035412T2/de not_active Expired - Lifetime
- 2000-03-03 WO PCT/US2000/005574 patent/WO2000052048A1/en not_active Ceased
- 2000-03-03 JP JP2000602272A patent/JP2002543043A/ja active Pending
- 2000-03-03 KR KR1020017011038A patent/KR100771712B1/ko not_active Expired - Fee Related
- 2000-03-03 BR BR0008738-6A patent/BR0008738A/pt not_active Application Discontinuation
- 2000-03-03 CA CA002362834A patent/CA2362834C/en not_active Expired - Fee Related
- 2000-03-03 PT PT00916028T patent/PT1161449E/pt unknown
- 2000-03-03 AT AT00916028T patent/ATE366259T1/de not_active IP Right Cessation
- 2000-03-03 RU RU2001127246/04A patent/RU2260599C2/ru active
- 2000-03-03 AU AU37196/00A patent/AU781292B2/en not_active Ceased
- 2000-03-03 HK HK02102235.9A patent/HK1040722B/en not_active IP Right Cessation
- 2000-03-03 CN CNB008071926A patent/CN1279053C/zh not_active Expired - Fee Related
-
2001
- 2001-09-26 ZA ZA200107913A patent/ZA200107913B/xx unknown
-
2003
- 2003-03-24 US US10/395,290 patent/US6831066B2/en not_active Expired - Fee Related
-
2004
- 2004-11-15 US US10/989,763 patent/US7803774B2/en not_active Expired - Fee Related
-
2007
- 2007-10-02 CY CY20071101254T patent/CY1106899T1/el unknown
-
2010
- 2010-12-24 JP JP2010287097A patent/JP2011121952A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR100771712B1 (ko) | 2007-10-30 |
| CN1279053C (zh) | 2006-10-11 |
| BR0008738A (pt) | 2001-12-26 |
| RU2260599C2 (ru) | 2005-09-20 |
| CA2362834C (en) | 2005-12-06 |
| ZA200107913B (en) | 2002-11-27 |
| US7803774B2 (en) | 2010-09-28 |
| US20030236197A1 (en) | 2003-12-25 |
| DE60035412T2 (de) | 2008-02-14 |
| JP2011121952A (ja) | 2011-06-23 |
| EP1161449B1 (de) | 2007-07-04 |
| US6831066B2 (en) | 2004-12-14 |
| HK1040722B (en) | 2008-02-22 |
| NZ514414A (en) | 2004-02-27 |
| JP2002543043A (ja) | 2002-12-17 |
| PT1161449E (pt) | 2007-10-12 |
| HK1040722A1 (en) | 2002-06-21 |
| CY1106899T1 (el) | 2012-09-26 |
| US6610658B1 (en) | 2003-08-26 |
| EP1161449A1 (de) | 2001-12-12 |
| AU3719600A (en) | 2000-09-21 |
| WO2000052048A9 (en) | 2002-04-11 |
| AU781292B2 (en) | 2005-05-12 |
| KR20020007316A (ko) | 2002-01-26 |
| ES2290023T3 (es) | 2008-02-16 |
| DE60035412D1 (de) | 2007-08-16 |
| CA2362834A1 (en) | 2000-09-08 |
| US20050137128A1 (en) | 2005-06-23 |
| DK1161449T3 (da) | 2007-11-05 |
| WO2000052048A1 (en) | 2000-09-08 |
| CN1362967A (zh) | 2002-08-07 |
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