DE69413637D1 - Verwendung von verzweigtkettigen Aminosäuren zur Herstellung eines Arzneimittels zur Behandlung von tardiver Dyskinesia - Google Patents
Verwendung von verzweigtkettigen Aminosäuren zur Herstellung eines Arzneimittels zur Behandlung von tardiver DyskinesiaInfo
- Publication number
- DE69413637D1 DE69413637D1 DE69413637T DE69413637T DE69413637D1 DE 69413637 D1 DE69413637 D1 DE 69413637D1 DE 69413637 T DE69413637 T DE 69413637T DE 69413637 T DE69413637 T DE 69413637T DE 69413637 D1 DE69413637 D1 DE 69413637D1
- Authority
- DE
- Germany
- Prior art keywords
- medicament
- manufacture
- treatment
- amino acids
- tardive dyskinesia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010043118 Tardive Dyskinesia Diseases 0.000 title abstract 2
- 150000005693 branched-chain amino acids Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/093,955 US5393784A (en) | 1993-07-21 | 1993-07-21 | Treatment of tardive dyskinesia with leucine, isoleucine, valine or mixtures thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69413637D1 true DE69413637D1 (de) | 1998-11-05 |
| DE69413637T2 DE69413637T2 (de) | 1999-05-27 |
Family
ID=22241901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69413637T Expired - Fee Related DE69413637T2 (de) | 1993-07-21 | 1994-07-19 | Verwendung von verzweigtkettigen Aminosäuren zur Herstellung eines Arzneimittels zur Behandlung von tardiver Dyskinesia |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5393784A (de) |
| EP (1) | EP0642791B1 (de) |
| AT (1) | ATE171620T1 (de) |
| CA (1) | CA2128486C (de) |
| DE (1) | DE69413637T2 (de) |
| DK (1) | DK0642791T3 (de) |
| ES (1) | ES2124342T3 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670539A (en) * | 1993-07-21 | 1997-09-23 | New York State Office Of Mental Health | Treatment of movement disorders using large neutral amino acids |
| US6077828A (en) | 1996-04-25 | 2000-06-20 | Abbott Laboratories | Method for the prevention and treatment of cachexia and anorexia |
| US5789443A (en) * | 1997-04-25 | 1998-08-04 | Gollobin; Charlotte | Method for treating flushing associated with menopause |
| US5891925A (en) * | 1997-06-27 | 1999-04-06 | Abbott Laboratories | Diagnostic method for assessing the serum cholesterol response to low diets |
| US6200758B1 (en) | 1999-02-19 | 2001-03-13 | New York State Office Of Mental Health | Phenylalanine hydroxylase gene variants, and amino acid and pterin homeostasis, in the definition, detection, treatment and prevention of psychotic, mood and personality disorders |
| US6245812B1 (en) | 1999-07-15 | 2001-06-12 | Charlotte Gollobin | Treatment of hot flashes (flushing) using leucine alone or in combination with other branched chain amino acids |
| AU2001266853B2 (en) | 2000-06-14 | 2005-02-17 | Medarex, Inc. | Prodrug compounds with an oligopeptide having an isoleucine residue |
| EP1575501A2 (de) * | 2002-07-12 | 2005-09-21 | University of Rochester | VERWENDUNG VON AMINOSûUREN ZUR BEHANDLUNG VERSCHIEDENER ERKRANKUNGEN |
| ITTO20030789A1 (it) | 2003-10-07 | 2005-04-08 | Professional Dietetics Srl | Composizione a base di amino acidi per il trattamento |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138484A (en) * | 1976-08-16 | 1979-02-06 | Nelson Research & Development Company | Method for treating schizophrenia and method and composition for potentiating neuroleptic drugs |
| US4129652A (en) * | 1976-08-16 | 1978-12-12 | Nelson Research & Development Company | Method for potentiating neuroleptic drugs |
| US4296119A (en) * | 1978-04-24 | 1981-10-20 | Massachusetts Institute Of Technology | Process and composition for reducing blood pressure in animals |
| US4209531A (en) * | 1978-09-13 | 1980-06-24 | Children's Hospital Medical Center | Method for treating phenylketonuria |
| US4252822A (en) * | 1979-12-26 | 1981-02-24 | Children's Hospital Medical Center | Method for treating phenylketonuria |
| US5028622A (en) * | 1988-05-06 | 1991-07-02 | Ajinomoto Company, Inc. | Administration of amino acids as treatment for neurodegenerative disorders |
| US5206218A (en) * | 1989-04-03 | 1993-04-27 | Interneuron Pharmaceuticals, Inc. | Reducing post-prandial fluctuations in plasma concentrations of large neutral amino acids (lnaa) |
-
1993
- 1993-07-21 US US08/093,955 patent/US5393784A/en not_active Expired - Lifetime
-
1994
- 1994-07-19 ES ES94111220T patent/ES2124342T3/es not_active Expired - Lifetime
- 1994-07-19 AT AT94111220T patent/ATE171620T1/de not_active IP Right Cessation
- 1994-07-19 DK DK94111220T patent/DK0642791T3/da active
- 1994-07-19 DE DE69413637T patent/DE69413637T2/de not_active Expired - Fee Related
- 1994-07-19 EP EP94111220A patent/EP0642791B1/de not_active Expired - Lifetime
- 1994-07-20 CA CA002128486A patent/CA2128486C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5393784A (en) | 1995-02-28 |
| DK0642791T3 (da) | 1999-06-21 |
| ES2124342T3 (es) | 1999-02-01 |
| EP0642791B1 (de) | 1998-09-30 |
| CA2128486C (en) | 2007-04-17 |
| DE69413637T2 (de) | 1999-05-27 |
| CA2128486A1 (en) | 1995-01-22 |
| ATE171620T1 (de) | 1998-10-15 |
| EP0642791A1 (de) | 1995-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |